메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages

Author keywords

[No Author keywords available]

Indexed keywords

IL10 PROTEIN, MOUSE; INTERLEUKIN 10; LCN2 PROTEIN, MOUSE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

EID: 84991661910     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep35014     Document Type: Article
Times cited : (48)

References (49)
  • 1
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of Crohns disease and ulcerative colitis
    • Sartor, R. B. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 3, 390-407 (2006).
    • (2006) Nat Clin Pract Gastroenterol Hepatol. , vol.3 , pp. 390-407
    • Sartor, R.B.1
  • 2
    • 84885959791 scopus 로고    scopus 로고
    • Review article: The association of diet with onset and relapse in patients with inflammatory bowel disease
    • Spooren, C. E. et al. Review article: the association of diet with onset and relapse in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 38, 1172-1187 (2013).
    • (2013) Aliment Pharmacol Ther. , vol.38 , pp. 1172-1187
    • Spooren, C.E.1
  • 3
    • 54949098181 scopus 로고    scopus 로고
    • The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway
    • Aamodt, G. et al. The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway. Am J Epidemiol. 168, 1065-1072 (2008).
    • (2008) Am J Epidemiol. , vol.168 , pp. 1065-1072
    • Aamodt, G.1
  • 4
    • 79851513757 scopus 로고    scopus 로고
    • Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis
    • Werner, T. et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis. Gut. 60, 325-333 (2011).
    • (2011) Gut. , vol.60 , pp. 325-333
    • Werner, T.1
  • 5
    • 0034684168 scopus 로고    scopus 로고
    • The lipocalin protein family: Structural and sequence overview
    • Flower, D. R., North, A. C. & Sansom, C. E. The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta. 1482, 9-24 (2000).
    • (2000) Biochim Biophys Acta. , vol.1482 , pp. 9-24
    • Flower, D.R.1    North, A.C.2    Sansom, C.E.3
  • 6
    • 0036865552 scopus 로고    scopus 로고
    • The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    • Goetz, D. H. et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell. 10, 1033-1043 (2002).
    • (2002) Mol Cell. , vol.10 , pp. 1033-1043
    • Goetz, D.H.1
  • 7
    • 33748094845 scopus 로고    scopus 로고
    • Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair
    • Playford, R. J. et al. Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair. Gastroenterology 131, 809-817 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 809-817
    • Playford, R.J.1
  • 8
    • 29244492306 scopus 로고    scopus 로고
    • A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    • Devireddy, L. R., Gazin, C., Zhu, X. & Green, M. R. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell. 123, 1293-1305 (2005).
    • (2005) Cell. , vol.123 , pp. 1293-1305
    • Devireddy, L.R.1    Gazin, C.2    Zhu, X.3    Green, M.R.4
  • 9
    • 18744397511 scopus 로고    scopus 로고
    • An iron delivery pathway mediated by a lipocalin
    • Yang, J. et al. An iron delivery pathway mediated by a lipocalin. Mol Cell. 10, 1045-1056 (2002).
    • (2002) Mol Cell. , vol.10 , pp. 1045-1056
    • Yang, J.1
  • 11
    • 11144314814 scopus 로고    scopus 로고
    • Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    • Flo, T. H. et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 432, 917-921 (2004).
    • (2004) Nature. , vol.432 , pp. 917-921
    • Flo, T.H.1
  • 12
    • 0027256664 scopus 로고
    • Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    • Kjeldsen, L., Johnsen, A. H., SengelOv, H. & Borregaard, N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 268, 10425-10432 (1993).
    • (1993) J Biol Chem. , vol.268 , pp. 10425-10432
    • Kjeldsen, L.1    Johnsen, A.H.2    Sengelov, H.3    Borregaard, N.4
  • 13
    • 0027198001 scopus 로고
    • Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages
    • Meheus, L. A. et al. Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. J Immunol. 151, 1535-1547 (1993).
    • (1993) J Immunol. , vol.151 , pp. 1535-1547
    • Meheus, L.A.1
  • 14
    • 65249089826 scopus 로고    scopus 로고
    • Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
    • Chan, Y. R. et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 182, 4947-4956 (2009).
    • (2009) J Immunol. , vol.182 , pp. 4947-4956
    • Chan, Y.R.1
  • 15
    • 84866015194 scopus 로고    scopus 로고
    • Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation
    • Chassaing, B. et al. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. Plos One. 7, e44328 (2012).
    • (2012) Plos One. , vol.7 , pp. e44328
    • Chassaing, B.1
  • 16
    • 0029981266 scopus 로고    scopus 로고
    • Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases
    • Nielsen, B. S. et al. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut. 38, 414-420 (1996).
    • (1996) Gut. , vol.38 , pp. 414-420
    • Nielsen, B.S.1
  • 17
    • 84881500778 scopus 로고    scopus 로고
    • Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
    • Ostvik A. E. et al. Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clin Exp Immunol. 173, 502-511 (2013).
    • (2013) Clin Exp Immunol , vol.173 , pp. 502-511
    • Ostvik, A.E.1
  • 18
    • 84865123537 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: Association with pathophysiology of inflammation, established markers, and disease activity
    • Oikonomou, K. A. et al. Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity. J Gastroenterol. 47, 519-530 (2012).
    • (2012) J Gastroenterol. , vol.47 , pp. 519-530
    • Oikonomou, K.A.1
  • 19
    • 77950597995 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin levels in patients with Crohn disease undergoing treatment with infliximab
    • Bolignano, D. et al. Neutrophil gelatinase-associated lipocalin levels in patients with crohn disease undergoing treatment with infliximab. J Investig Med. 58, 569-571 (2010).
    • (2010) J Investig Med. , vol.58 , pp. 569-571
    • Bolignano, D.1
  • 20
    • 0032870150 scopus 로고    scopus 로고
    • Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis
    • Nielsen, O. H. et al. Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis. Am J Gastroenterol. 94, 2923-2928 (1999).
    • (1999) Am J Gastroenterol. , vol.94 , pp. 2923-2928
    • Nielsen, O.H.1
  • 21
    • 84889077298 scopus 로고    scopus 로고
    • The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases
    • Valatas, V., Vakas, M. & Kolios, G. The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol. 305, G763-G785 (2013).
    • (2013) Am J Physiol Gastrointest Liver Physiol. , vol.305 , pp. G763-G785
    • Valatas, V.1    Vakas, M.2    Kolios, G.3
  • 22
    • 84900448316 scopus 로고    scopus 로고
    • Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
    • Zigmond, E. et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity. 40, 720-733 (2014).
    • (2014) Immunity. , vol.40 , pp. 720-733
    • Zigmond, E.1
  • 23
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol. 10, 131-144 (2010).
    • (2010) Nat Rev Immunol. , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 24
    • 0346996867 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha
    • Cowland, J. B., SOrensen, O. E., Sehested, M. & Borregaard, N. Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J Immunol. 171, 6630-6639 (2003).
    • (2003) J Immunol. , vol.171 , pp. 6630-6639
    • Cowland, J.B.1    Sorensen, O.E.2    Sehested, M.3    Borregaard, N.4
  • 25
    • 84861872216 scopus 로고    scopus 로고
    • Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
    • Cayatte, C. et al. Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease. Clin Transl Gastroenterol. 16, e10 (2012).
    • (2012) Clin Transl Gastroenterol. , vol.16 , pp. e10
    • Cayatte, C.1
  • 26
    • 84942278816 scopus 로고    scopus 로고
    • Lipocalin-2 Is a disease activity marker in inflammatory bowel disease regulated by IL-17A IL-22 and TNF-α and Modulated by IL23R Genotype Status
    • Stallhofer, J. et al. Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status. Inflamm Bowel Dis. 21, 2327-2340 (2015).
    • (2015) Inflamm Bowel Dis. , vol.21 , pp. 2327-2340
    • Stallhofer, J.1
  • 27
    • 84857467280 scopus 로고    scopus 로고
    • Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis
    • Obata, Y. et al. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J Immunol. 188, 2427-2436 (2012).
    • (2012) J Immunol. , vol.188 , pp. 2427-2436
    • Obata, Y.1
  • 28
    • 84862862332 scopus 로고    scopus 로고
    • Epithelial antimicrobial defence of the skin and intestine
    • Gallo, R. L. & Hooper, L. V. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 12, 503-516 (2012).
    • (2012) Nat Rev Immunol. , vol.12 , pp. 503-516
    • Gallo, R.L.1    Hooper, L.V.2
  • 29
    • 84975221149 scopus 로고    scopus 로고
    • Microbiota-inducible innate immune siderophore binding protein lipocalin 2 is critical for intestinal homeostasis
    • Singh, V. et al. Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis. Cell Mol Gastroenterol Hepatol. 2, 482-498 (2016).
    • (2016) Cell Mol Gastroenterol Hepatol. , vol.2 , pp. 482-498
    • Singh, V.1
  • 30
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier, E. L. et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol. 13, 1118-1128 (2012).
    • (2012) Nat Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1
  • 31
    • 44649173850 scopus 로고    scopus 로고
    • The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages
    • Zhang, J. et al. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol. 22, 1416-1426 (2008).
    • (2008) Mol Endocrinol. , vol.22 , pp. 1416-1426
    • Zhang, J.1
  • 32
    • 84881232123 scopus 로고    scopus 로고
    • Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
    • Warszawska, J. M. et al. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest. 123, 3363-3372 (2013).
    • (2013) J Clin Invest. , vol.123 , pp. 3363-3372
    • Warszawska, J.M.1
  • 33
    • 84886797274 scopus 로고    scopus 로고
    • Autophagy in infection, inflammation and immunity
    • Deretic, V., Saitoh, T. & Akira, S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 13, 722-737 (2013).
    • (2013) Nat Rev Immunol. , vol.13 , pp. 722-737
    • Deretic, V.1    Saitoh, T.2    Akira, S.3
  • 34
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux, J. D. et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39, 596-604 (2007).
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1
  • 35
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39, 207-211 (2007).
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1
  • 36
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll, S. A. et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40, 1107-1112 (2008).
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1
  • 37
    • 84901660514 scopus 로고    scopus 로고
    • Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
    • Lassen, K. G. et al. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci USA 111, 7741-7746 (2014).
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7741-7746
    • Lassen, K.G.1
  • 38
    • 84884340814 scopus 로고    scopus 로고
    • Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
    • Bonilla, D. L. et al. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity. 39, 537-547 (2013).
    • (2013) Immunity. , vol.39 , pp. 537-547
    • Bonilla, D.L.1
  • 39
    • 54349085334 scopus 로고    scopus 로고
    • Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
    • Mikami, S. et al. Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther. 327, 383-392 (2008).
    • (2008) J Pharmacol Exp Ther. , vol.327 , pp. 383-392
    • Mikami, S.1
  • 40
    • 80053574887 scopus 로고    scopus 로고
    • SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation
    • Uza, N. et al. SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation. Gut. 60, 1494-1505 (2011).
    • (2011) Gut. , vol.60 , pp. 1494-1505
    • Uza, N.1
  • 41
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon, R. K. et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 66, 5224-5231 (1998).
    • (1998) Infect Immun. , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 42
    • 0032408502 scopus 로고    scopus 로고
    • Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice
    • Arai, Y., Takanashi, H., Kitagawa, H. & Okayasu, I. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine. 10, 890-896 (1998).
    • (1998) Cytokine. , vol.10 , pp. 890-896
    • Arai, Y.1    Takanashi, H.2    Kitagawa, H.3    Okayasu, I.4
  • 43
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodiuminduced colitis in mice
    • Ogawa, A., Andoh, A., Araki, Y., Bamba, T. & Fujiyama, Y. Neutralization of interleukin-17 aggravates dextran sulfate sodiuminduced colitis in mice. Clin Immunol. 110, 55-62 (2004).
    • (2004) Clin Immunol. , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5
  • 44
    • 0347297590 scopus 로고    scopus 로고
    • Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces
    • Nagashima, K., Hisada, T., Sato, M. & Mochizuki, J. Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces. Appl Environ Microbiol. 69, 1251-1262 (2003).
    • (2003) Appl Environ Microbiol. , vol.69 , pp. 1251-1262
    • Nagashima, K.1    Hisada, T.2    Sato, M.3    Mochizuki, J.4
  • 45
    • 67650097623 scopus 로고    scopus 로고
    • Phylogenetic analysis of 16S ribosomal RNA gene sequences from Human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling
    • Nagashima, K., Mochizuki, J., Hisada, T., Suzuki, S. & Shimomura, K. Phylogenetic analysis of 16S ribosomal RNA gene sequences from Human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling. Bioscience Microflora. 25, 99-107 (2006).
    • (2006) Bioscience Microflora. , vol.25 , pp. 99-107
    • Nagashima, K.1    Mochizuki, J.2    Hisada, T.3    Suzuki, S.4    Shimomura, K.5
  • 46
    • 84875612653 scopus 로고    scopus 로고
    • Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease
    • Fujimoto, T. et al. Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease. J Gastroenterol Hepatol. 28, 613-619 (2013).
    • (2013) J Gastroenterol Hepatol. , vol.28 , pp. 613-619
    • Fujimoto, T.1
  • 47
    • 0034679577 scopus 로고    scopus 로고
    • Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis.I. Effects on microbial killing by activated peritoneal macrophages in vitro
    • Vazquez-Torres, A., Jones-Carson, J., Mastroeni, P., Ischiropoulos, H. & Fang, F. C. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J Exp Med. 192, 227-236 (2000).
    • (2000) J Exp Med. , vol.192 , pp. 227-236
    • Vazquez-Torres, A.1    Jones-Carson, J.2    Mastroeni, P.3    Ischiropoulos, H.4    Fang, F.C.5
  • 48
    • 84055200171 scopus 로고    scopus 로고
    • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
    • Medina-Contreras, O. et al. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest. 121, 4787-4795 (2011).
    • (2011) J Clin Invest. , vol.121 , pp. 4787-4795
    • Medina-Contreras, O.1
  • 49
    • 84872086586 scopus 로고    scopus 로고
    • Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease
    • Bakhautdin, B. et al. Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease. Gut. 62, 209-219 (2013).
    • (2013) Gut. , vol.62 , pp. 209-219
    • Bakhautdin, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.