Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling

Journal of the American Heart Association

Volumn 5, Issue 3, 2015, Pages

  Hashimoto, Toru ^a   Sivakumaran, Vidhya ^a   Carnicer, Ricardo ^a,b   Zhu, Guangshuo ^a   Hahn, Virginia S ^a   Bedja, Djahida ^a   Recalde, Alice ^b   Duglan, Drew ^b   Channon, Keith M ^b   Casadei, Barbara ^b,c   Kass, David A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Hypertrophy; Inflammation; Myocardium; Nitric oxide synthase; Oxidative stress

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TETRAHYDROBIOPTERIN; ANTIINFLAMMATORY AGENT; AUTACOID; BIOPTERIN; CARDIOVASCULAR AGENT; CYTOKINE; NITRIC OXIDE; SAPROPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; MACROPHAGE MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANIMAL; CARDIAC MUSCLE CELL; CELL PROTECTION; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPERTROPHY, LEFT VENTRICULAR; MACROPHAGE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PATHOPHYSIOLOGY; PREVENTION AND CONTROL; SIGNAL TRANSDUCTION; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOPTERIN; CARDIOVASCULAR AGENTS; CYTOKINES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GTP CYCLOHYDROLASE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INFLAMMATION MEDIATORS; MACROPHAGES; MICE, TRANSGENIC; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; SUPEROXIDES; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84991520256     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.003208     Document Type: Article

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