A methyl 4-oxo-4-phenylbut-2-enoate with in vivo activity against MRSA that inhibits MenB in the bacterial menaquinone biosynthesis pathway

ACS Infectious Diseases

Volumn 2, Issue 5, 2016, Pages 329-340

  Matarlo, Joe S ^a   Lu, Yang ^a   Daryaee, Fereidoon ^a   Daryaee, Taraneh ^a   Ruzsicska, Bela ^a   Walker, Stephen G ^a   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

DHNA; electrophilic antibacterial compound; menadione; menaquinone biosynthesis; MenB; Staphylococcus aureus

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; COENZYME A; MENADIONE; MENAQUINONE; METHYL 4 OXO 4 (4 CHLOROPHENYL) 2 BUTENOATE; METHYL 4 OXO 4 PHENYLBUT 2 ENOATE; OXACILLIN; PROTEIN MENB; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL LOAD; BACTERIAL STRAIN; BACTERIUM COLONY; BINDING AFFINITY; BIOSYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; HAEMOPHILUS; IN VIVO STUDY; MALE; MENB GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; STAPHYLOCOCCUS AUREUS; SURVIVAL;

EID: 84991519029     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00023     Document Type: Article

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