Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: Chemical hydrolysis and anti-bacterial activity

Pharmaceutical Research

Volumn 13, Issue 1, 1996, Pages 70-75

  Moreira, Rui ^a   Calheiros, Teresa ^a   Cabrita, José ^a   Mendes, Eduarda ^a   Pimentel, Madalena ^a   Iley, Jim ^b  

^a UNIVERSITY OF LISBON   (Portugal)

^b OPEN UNIVERSITY   (United Kingdom)

Author keywords

Antibacterial activity; Carboxylic acids; Hydrolysis kinetics; Mechanism of hydrolysis; O amidomethylation; Penicillin G; Prodrugs

Indexed keywords

PENICILLIN G DERIVATIVE; PRODRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KINETICS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ACYLATION; CATALYSIS; DRUG STABILITY; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; METHYLATION; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PENICILLIN G; PENICILLINS; PRODRUGS;

EID: 0029865020     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016077200460     Document Type: Article

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