Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

Heart Rhythm

Volumn 13, Issue 8, 2016, Pages 1699-1706

  Joseph, Leroy C ^a   Subramanyam, Prakash ^a   Radlicz, Christopher ^a   Trent, Chad M ^a   Iyer, Vivek ^a   Colecraft, Henry M ^a   Morrow, John P ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

Arrhythmia; Calcium; Lipid metabolism; Oxidative stress

Indexed keywords

ANTIOXIDANT; MITOTEMPO; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG; CALCIUM; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; CELL ISOLATION; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HEART RHYTHM; HEART STRESS; IN VIVO STUDY; LIPOTOXICITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; HEART MITOCHONDRION; INTRACELLULAR FLUID; LIPID METABOLISM; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; DISEASE MODELS, ANIMAL; INTRACELLULAR FLUID; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PPAR GAMMA;

EID: 84991512622     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2016.05.002     Document Type: Article

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