Depolarization-dependent contraction increase after birth and preservation following long-term hypoxia in sheep pulmonary arteries

Pulmonary Circulation

Volumn 2, Issue 1, 2012, Pages 41-53

  Papamatheakis, Demosthenes G ^a   Patel, Jay J ^c   Blood, Quintin ^c   Merritt, Travis T ^c   Longo, Lawrence D ^c   Wilson, Sean M ^b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO HEALTH SYSTEM   (United States)

^b LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

K+ induced depolarization; L type Ca2+ channel; Myography; Rho kinase; Superoxide

Indexed keywords

EID: 84991339382     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.4103/2045-8932.94832     Document Type: Article

References (43)

1. Ward JP, Snetkov VA. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: Use of the small vessel myograph. Methods Enzymol 2004;381:71-87.
2. Sanderson MJ, Bai Y, Perez-Zoghbi J. Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cells. Adv Exp Med Biol 2010;661: 77-96.
3. Goyal R, Papamatheakis DG, Loftin M, Vrancken K, Dawson AS, Osman NJ, et al. Long-term maternal hypoxia: The role of extracellular Ca2+ entry during serotonin-mediated contractility in fetal ovine pulmonary arteries. Reprod Sci 2011;18:948-62.
4. Papamatheakis DG, Vemulakonda S, Blood Q, Goyal R, Rubalcava M, Vrancken K, et al. Preservation of serotonin-mediated contractility in adult sheep pulmonary arteries following long-term high-altitude hypoxia. High Alt Med Biol 2011;12:253-64.
5. Wilson SM, Mason HS, Ng LC, Montague S, Johnston L, Nicholson N, et al. Role of basal extracellular Ca2+ entry during 5-HT-induced vasoconstriction of canine pulmonary arteries. Br J Pharmacol 2005;144:252-64.
6. Mita M, Yanagihara H, Hishinuma S, Saito M, Walsh MP. Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J 2002;364:431-40.
7. Urban NH, Berg KM, Ratz PH. K+ depolarization induces RhoA kinase translocation to caveolae and Ca2+ sensitization of arterial muscle. Am J Physiol Cell Physiol 2003;285:C1377-85.
8. Broughton BR, Jernigan NL, Norton CE, Walker BR, Resta TC. Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. Am J Physiol Lung Cell Mol Physiol 2010;298:L232-42.
9. Broughton BR, Walker BR, Resta TC. Chronic hypoxia induces Rho kinasedependent myogenic tone in small pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2008;294:L797-806.
10. Shimoda LA, Sham JS, Shimoda TH, Sylvester JT. L-type Ca(2+) channels, resting [Ca(2+)](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 2000;279:L884-94.
11. Hirenallur SD, Haworth ST, Leming JT, Chang J, Hernandez G, Gordon JB, et al. Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2008;295:L915-24.
12. Goyal R, Henderson DA, Chu N, Longo LD. Ovine Middle Cerebral Artery Characterization and Quantification of Ultrastructure and Other Features: Changes with Development. Am J Physiol Regul Integr Comp Physiol 2011 Nov 23. [Epub ahead of print].
13. Blood AB, Zhao Y, Long W, Zhang L, Longo LD. L-type Ca2+ channels in fetal and adult ovine cerebral arteries. Am J Physiol Regul Integr Comp Physiol 2002;282:R131-8.
14. Longo LD, Ueno N, Zhao Y, Zhang L, Pearce WJ. NE-induced contraction, alpha 1-adrenergic receptors, and Ins(1,4,5)P3 responses in cerebral arteries. Am J Physiol Renal Physiol 1996;270:H915-23.
15. Kamitomo M, Longo LD, Gilbert RD. Cardiac function in fetal sheep during two weeks of hypoxemia. Am J Physiol Renal Physiol 1994;266: R1778-85.
16. Zhao Y, Xiao H, Long W, Pearce WJ, Longo LD. Expression of several cytoskeletal proteins in ovine cerebral arteries: Developmental and functional considerations. J Physiol 2004;558:623-32.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
18. Rasband WS. Image J. In. Bethesda, Maryland, USA,: U. S. National Institutes of Health; 2011.
19. Resta TC, Broughton BR, Jernigan NL. Reactive oxygen species and RhoA signaling in vascular smooth muscle: Role in chronic hypoxia-induced pulmonary hypertension. Adv Exp Med Biol 2010;661:355-73.
20. Dennis KE, Aschner JL, Milatovic D, Schmidt JW, Aschner M, Kaplowitz MR, et al. NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol 2009;297:L596-607.
21. Fike CD, Slaughter JC, Kaplowitz MR, Zhang Y, Aschner JL. Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2008;295:L881-8.
22. Knock GA, Snetkov VA, Shaifta Y, Connolly M, Drndarski S, Noah A, et al. Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization. Free Radic Biol Med 2009;46:633-42.
23. Ostrovskaya O, Goyal R, Osman N, McAllister CE, Pessah IN, Hume JR, et al. Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells. J Pharmacol Exp Ther 2007;323:381-90.
24. Pluteanu F, Cribbs LL. Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 2011;300:C517-25.
25. Rodman DM, Reese K, Harral J, Fouty B, Wu S, West J, et al. Low-voltageactivated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res 2005;96:864-72.
26. Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, Yuan JX. Functional ion channels in human pulmonary artery smooth muscle cells: Voltagedependent cation channels. Pulm Circ 2011;1:48-71.
27. Saleh S, Yeung SY, Prestwich S, Pucovsky V, Greenwood I. Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes. J Physiol 2005;568:155-69.
28. Platoshyn O, Remillard CV, Fantozzi I, Sison T, Yuan JX. Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells. Pflugers Arch 2005;451:380-7.
29. Zamponi GW. Antagonist binding sites of voltage-dependent calcium channels. Drug Develop Res 1997;42:131-43.
30. Liu L, O’Hara DS, Cala SE, Poornima I, Hines RN, Marsh JD. Developmental regulation of the L-type calcium channel alpha1C subunit expression in heart. Mol Cell Biochem 2000;205:101-9.
31. Ratz PH, Berg KM, Urban NH, Miner AS. Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus. Am J Physiol Cell Physiol 2005;288:C769-83.
32. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 2004;287:L656-64.
33. Parker TA, Roe G, Grover TR, Abman SH. Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 2006;291:L976-82.
34. Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, et al. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol 2007;50:697-702.
35. Gao Y, Portugal AD, Negash S, Zhou W, Longo LD, Usha Raj J. Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. Am J Physiol Lung Cell Mol Physiol 2007;292:L678-84.
36. Gao Y, Portugal AD, Liu J, Negash S, Zhou W, Tian J, et al. Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: Role of PKG and Rho kinase. Am J Physiol Lung Cell Mol Physiol 2008;295:L889-96.
37. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, et al. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 2005;171:494-9.
38. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, et al. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 2006;100:996-1002.
39. Szaszi K, Sirokmany G, Di Ciano-Oliveira C, Rotstein OD, Kapus A. Depolarization induces Rho-Rho kinase-mediated myosin light chain phosphorylation in kidney tubular cells. Am J Physiol Cell Physiol 2005;289:C673-85.
40. Alvarez SM, Miner AS, Browne BM, Ratz PH. Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels. Br J Pharmacol 2010;160:1326-37.
41. Abman SH, Shanley PF, Accurso FJ. Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs. J Clin Invest 1989;83:1849-58.
42. Abman SH, Accurso FJ. Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. Am J Physiol 1991;260:H183-92.
43. Tourneux P, Chester M, Grover T, Abman SH. Fasudil inhibits the myogenic response in the fetal pulmonary circulation. Am J Physiol Heart Circ Physiol 2008;295:H1505-13.