Erlotinib induces the human non–small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways

Cancer Medicine

Volumn 5, Issue 11, 2016, Pages 3166-3175

  Shan, Fenglian ^a,b   Shao, Zewei ^b   Jiang, Shenghua ^a,b   Cheng, Zhaozhong ^a  

^a QINGDAO UNIVERSITY   (China)

^b JINING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; EFGR; erlotinib; JNK; MMP; ROS

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MATRIX METALLOPROTEINASE; PHOSPHOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; EGFR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; LUNG TUMOR; MAPK SIGNALING; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; ERLOTINIB HYDROCHLORIDE; GENE EXPRESSION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84991086839     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.881     Document Type: Article

References (32)

1. Torre, L. A., F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal. 2015. Global cancer statistics, 2012. CA Cancer J. Clin. 65:87–108.
2. Lowe, S. W., and A. W. Lin. 2000. Apoptosis in cancer. Carcinogenesis 21:485–495.
3. Arteaga, C. 2003. Targeting HER1/EGFR: a molecular approach to cancer therapy. Semin. Oncol. 30:3–14.
4. Mendelsohn, J., and J. Baselga. 2000. The EGF receptor family as targets for cancer therapy. Oncogene 19:6550–6565.
5. Brabender, J., K. D. Danenberg, R. Metzger, P. M. Schneider, J. Park, D. Salonga, et al. 2001. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival. Clin. Cancer Res. 7:1850–1855.
6. Ling, Y. H., T. Li, Z. Yuan, M. Jr Haigentz, T. K. Weber, and R. Perez-Soler. 2007. Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lines. Mol. Pharmacol. 72:248–258.
7. Xie, J., Y. Xu, X. Huang, Y. Chen, J. Fu, M. Xi, et al. 2015. Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway. Tumour Biol. 36:1279–1288.
8. Qi, D., H. Liu, J. Niu, X. Fan, X. Wen, Y. Du, et al. 2012. Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia. J. Neurol. Sci. 317:123–129.
9. Formentini, L., M. Sanchez-Arago, L. Sanchez-Cenizo, and J. M. Cuezva. 2012. The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response. Mol. Cell 45:731–742.
10. Lenaz, G. 2012. Mitochondria and reactive oxygen species. Which role in physiology and pathology? Adv. Exp. Med. Biol. 942:93–136.
11. Kuo, P. L., C. Y. Chen, and Y. L. Hsu. 2007. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res. 67:7406–7420.
12. Haddad, J. J. 2004. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int. Immunopharmacol. 4:475–493.
13. Schumacker, P. T. 2006. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10:175–176.
14. Boye, K., H. Jacob, K. M. Frikstad, J.M. Nesland, G.M. Maelandsmo, O. Dahl, et al. 2016. Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy. Cancer Med. 5:1840–1849.
15. Gupta, P., C. Adkins, P. Lockman, and S. K. Srivastava. 2013. Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel metastasis model. PLoS ONE 8:e67278.
16. Khan, M., A. Maryam, J. I. Qazi, and T. Ma. 2015. Targeting apoptosis and multiple signaling pathways with icariside ii in cancer cells. Int. J. Biol. Sci. 11:1100–1112.
17. Queiroz, E. A., Z. B. Fortes, M. A. da Cunha, A. M. Barbosa, N. Khaper, and R. F. Dekker. 2015. Antiproliferative and pro-apoptotic effects of three fungal exocellular beta-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a. Int. J. Biochem. Cell Biol. 67:14–24.
18. Zhang, X., X. Wang, T. Wu, B. Li, T. Liu, R. Wang, et al. 2015. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci. Rep. 5:12579.
19. Qi, D., C. Ouyang, Y. Wang, S. Zhang, X. Ma, Y. Song, et al. 2014. HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. Brain Res. 1577:69–76.
20. Del Poeta, G., A. Venditti, M. I. Del Principe, L. Maurillo, F. Buccisano, A. Tamburini, et al. 2003. Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML). Blood 101:2125–2131.
21. Beenken, S. W., and K. I. Bland. 2002. Biomarkers for breast cancer. Minerva Chir. 57:437–448.
22. Kroemer, G., and J. C. Reed. 2000. Mitochondrial control of cell death. Nat. Med. 6:513–519.
23. Youle, R. J., and A. Strasser. 2008. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9:47–59.
24. Pathak, N., and S. Khandelwal. 2006. Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium. Toxicology 220:26–36.
25. Jacobson, M. D. 1996. Reactive oxygen species and programmed cell death. Trends Biochem. Sci. 21:83–86.
26. Wu, C. C., and S. B. Bratton. 2013. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid. Redox Signal. 19:546–558.
27. Kello, M., D. Drutovic, M. Chripkova, M. Pilatova, M. Budovska, L. Kulikova, et al. 2014. ROS-dependent antiproliferative effect of brassinin derivative homobrassinin in human colorectal cancer Caco2 cells. Molecules 19:10877–10897.
28. Hsieh, C. J., P. L. Kuo, Y. C. Hsu, Y. F. Huang, E. M. Tsai, and Y. L. Hsu. 2014. Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. Free Radic. Biol. Med. 67:159–170.
29. Vriz, S., S. Reiter, and B. Galliot. 2014. Cell death: a program to regenerate. Curr. Top. Dev. Biol. 108:121–151.
30. Ma, J., J. Liu, C. Lu, and D. Cai. 2015. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 15:78.
31. Coulthard, L. R., D. E. White, D. L. Jones, M. F. McDermott, and S. A. Burchill. 2009. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol. Med. 15:369–379.
32. Xu, Y., D. Wang, Z. Zhuang, K. Jin, L. Zheng, Q. Yang, et al. 2015. Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. Mol. Med. Rep. 12:6475–6482.