Oral supplementation of healthy adults with 2′-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota

British Journal of Nutrition

Volumn 116, Issue 8, 2016, Pages 1356-1368

  Elison, Emma ^a   Vigsnaes, Louise K ^a   Rindom Krogsgaard, Laura ^b,c   Rasmussen, Julie ^b,c   Sorensen, Nikolaj ^d   McConnell, Bruce ^a   Hennet, Thierry ^e   Sommer, Morten O A ^f   Bytzer, Peter ^b,c  

^a Glycom A/S   (Denmark)

^b ZEALAND UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Clinical Microbiomics ApS   (Denmark)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f Chalmers University of Technology   (Denmark)

Author keywords

2' O Fucosyllactose; Clinical study; Lacto N neotetraose; Safety; Tolerance

Indexed keywords

2' O FUCOSYLLACTOSE; GLYCAN; LACTO N NEOTETRAOSE; OLIGOSACCHARIDE; PLACEBO; RNA 16S; UNCLASSIFIED DRUG; 2'-FUCOSYLLACTOSE; BIOLOGICAL MARKER; LACTO-N-NEOTETRAOSE; PREBIOTIC AGENT; TRISACCHARIDE;

ACTINOBACTERIA; ADULT; ARTICLE; BIFIDOBACTERIUM; BLOATING; CONSTIPATION; CONTROLLED STUDY; DEFECATION URGENCY; DIARRHEA; DIETARY SUPPLEMENT; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; FECES MICROFLORA; FEMALE; FIRMICUTES; FLATULENCE; GASTROINTESTINAL SYMPTOM RATING SCALE; HUMAN; INTESTINE FLORA; LOOSE FECES; MALE; NAUSEA; NONHUMAN; NORMAL HUMAN; PATIENT COMPLIANCE; POPULATION ABUNDANCE; PROSPECTIVE STUDY; PROTEOBACTERIA; RANDOMIZED CONTROLLED TRIAL; RNA ANALYSIS; RNA SEQUENCE; SPECIES COMPOSITION; STOMACH PAIN; SUPPLEMENTATION; SYMPTOM ASSESSMENT; BLOOD; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DENMARK; DYSBIOSIS; FECES; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MOLECULAR TYPING; PRINCIPAL COMPONENT ANALYSIS; YOUNG ADULT;

ACTINOBACTERIA; ADULT; BIFIDOBACTERIUM; BIOMARKERS; DENMARK; DOUBLE-BLIND METHOD; DYSBIOSIS; FECES; FEMALE; FIRMICUTES; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; MIDDLE AGED; MOLECULAR TYPING; OLIGOSACCHARIDES; PREBIOTICS; PRINCIPAL COMPONENT ANALYSIS; PROTEOBACTERIA; TRISACCHARIDES; YOUNG ADULT;

EID: 84990928857     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114516003354     Document Type: Article

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