Pre-clinical safety assessment of the synthetic human milk, nature-identical, oligosaccharide Lacto-N-neotetraose (LNnT)

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 528-537

  Coulet, Myriam ^a   Phothirath, Phoukham ^a   Constable, Anne ^a   Marsden, Edward ^b   Schilter, Benoit ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b Ricerca Biosciences SAS   (France)

Author keywords

Gavage; Human milk oligosaccharides; Juvenile rats; LNnT; Mutagenicity; Sub chronic toxicity

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; LACTO N NEOTETRAOSE; TETRASACCHARIDE; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL MILK; BREAST MILK; CLINICAL STUDY; FEMALE; FOOD ANALYSIS; FOOD COMPOSITION; FOOD SAFETY; GENOTOXICITY; HISTOPATHOLOGY; IN VITRO STUDY; JUVENILE ANIMAL; MALE; NONHUMAN; NUTRITIONAL TOLERANCE; ORGAN WEIGHT; RAT; SYNTHETIC HUMAN MILK; WEIGHT GAIN;

RATTUS;

AG RATIO; ALANINE TRANSFERASE; ALAT; ALB; ALBUMIN; ALBUMIN/GLOBULIN RATIO; ALKALINE PHOSPHATASE; ALP; ASAT; ASPARTATE AMINOTRANSFERASE; BILI; CA; CALCIUM; CHLORIDE; CHOL; CL; CP; CREAT; CREATININE; CYCLOPHOSPHAMIDE; FOS; FRUCTOOLIGOSACCHARIDE; GALACTOOLIGOSACCHARIDE; GAVAGE; GLOB; GLOBULIN; GOS; HB; HEAMOGLOBIN; HMO; HUMAN MILK OLIGOSACCHARIDES; IF; INFANT FORMULA; JUVENILE RATS; K; LACTO-N-NEOTETRAOSE; LNNT; MARGIN OF EXPOSURE; MCH; MCHC; MCV; MEAN CORPUSCULAR HEAMOGLOBIN; MEAN CORPUSCULAR HEAMOGLOBIN CONCENTRATION; MEAN CORPUSCULAR VOLUME; METHYL METHANESULPHONATE; MF; MMS; MOE; MUTAGENICITY; MUTANT FREQUENCY FOR 106 CELLS; NA; ND; NO DATA; NO OBSERVED ADVERSE EFFECT LEVEL; NOAEL; PACK CELL VOLUME; PCV; PND; POSTNATAL DAY; POTASSIUM; PROT; RBC; RED BLOOD CELLS; RELATIVE SURVIVAL; RELATIVE TOTAL GROWTH; RETI; RETICULOCYTES; RS; RTG; SODIUM; SUB-CHRONIC TOXICITY; TFT; THYMIDINE KINASE; TK; TOTAL BILIRUBIN; TOTAL CHOLESTEROL; TOTAL PROTEIN; TRIFLUOROTHYMIDINE; WBC; WHITE BLOOD CELLS;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MICE; MILK, HUMAN; MUTAGENICITY TESTS; OLIGOSACCHARIDES; RATS; RATS, WISTAR; TOXICITY TESTS;

EID: 84885217503     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.09.018     Document Type: Article

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