Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhang, Yujing ^a   Zhang, Yiyuan ^a   Zhong, Caigao ^a   Xiao, Fang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM; CHROMIUM HEXAVALENT ION; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); TP53 PROTEIN, HUMAN;

CELL AGING; CELL LINE; CELL SURVIVAL; DRUG EFFECT; HUMAN; LIVER CELL; METABOLISM; PHOSPHORYLATION;

CELL LINE; CELL SURVIVAL; CELLULAR SENESCENCE; CHROMIUM; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; HEPATOCYTES; HUMANS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84990818530     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep34578     Document Type: Article

References (46)

1. Barceloux, D. G. Chromium. J Toxicol Clin Toxicol 37, 173-194 (1999).
2. Wilbur, S. B., Corporation, S. R., Substances, U. S. A. f. T. & Registry, D. Toxicological profile for chromium, (US Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, 2000).
3. Hayflick, L. The Limited in Vitro Lifetime of Human Diploid Cell Strains. Exp Cell Res 37, 614-636 (1965).
4. Singer, M. S. & Gottschling, D. E. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266, 404-409 (1994).
5. Hunt, A., Betts, D., King, W. A. & Madan, P. Senescence or apoptosis? The choice bovine fibroblasts make in the presence of increasing concentrations of extracellular H2O2. Studies by Undergraduate Researchers at Guelph 3, 64-68 (2010).
6. Toussaint, O., Medrano, E. E. & von Zglinicki, T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35, 927-945 (2000).
7. Lee, S., Schmitt, C. A. & Reimann, M. The Myc/macrophage tango: Oncogene-induced senescence, Myc style. Semin Cancer Biol 21, 377-384 (2011).
8. Suzuki, M., Suzuki, K., Kodama, S. & Watanabe, M. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Biochem Biophys Res Commun 340, 145-150 (2006).
9. Pedro de Magalhaes, J. et al. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Experimental gerontology 39, 1379-1389 (2004).
10. Ungvari, Z. et al. Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency. Age (Dordr) 30, 121-133 (2008).
11. Wallace, D. C. Mitochondrial diseases in man and mouse. Science 283, 1482-1488 (1999).
12. Wang, S., Leonard, S. S., Ye, J., Ding, M. & Shi, X. The role of hydroxyl radical as a messenger in Cr (VI)-induced p53 activation. American Journal of Physiology-Cell Physiology 279, C868-C875 (2000).
13. Bringold, F. & Serrano, M. Tumor suppressors and oncogenes in cellular senescence. Experimental gerontology 35, 317-329 (2000).
14. Artandi, S. E. & Attardi, L. D. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Biochemical and biophysical research communications 331, 881-890 (2005).
15. De Falco, G., Comes, F. & Simone, C. pRb: master of differentiation. Coupling irreversible cell cycle withdrawal with induction of muscle-specific transcription. Oncogene 25, 5244-5249 (2006).
16. Liu, B., Chen, Y. & St Clair, D. K. ROS and p53: a versatile partnership. Free Radical Biology and Medicine 44, 1529-1535 (2008).
17. Brustovetsky, N., Brustovetsky, T., Jemmerson, R. & Dubinsky, J. M. Calciuminduced Cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane. Journal of neurochemistry 80, 207-218 (2002).
18. Alexopoulos, E. C. et al. Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J/Clusterin in welders. Bioinorg Chem Appl. 420578 (2008).
19. Katsiki, M. et al. Alterations of senescence biomarkers in human cells by exposure to CrVI in vivo and in vitro. Exp Gerontol 39, 1079-1087 (2004).
20. Coppé, J.-P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. Plos Biology 6, 2853-2868 (2009).
21. Adams, P. D. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 397, 84-93 (2007).
22. Aird, K. M. & Zhang, R. Detection of Senescence-Associated Heterochromatin Foci (SAHF). Methods in Molecular Biology 965, 185-196 (2013).
23. Nag, S., Qin, J., Srivenugopal, K. S., Wang, M. & Zhang, R. The MDM2-p53 pathway revisited. J Biomed Res 27, 254-271 (2013).
24. Cheng, Q. & Chen, J. Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle 9, 472-478 (2010).
25. Prieur, A. & Peeper, D. S. Cellular senescence in vivo: a barrier to tumorigenesis. Current opinion in cell biology 20, 150-155 (2008).
26. Blagosklonny, M. V. Cell cycle arrest is not senescence. Aging (Albany NY) 3, 94-101 (2011).
27. Kurz, D. J., Decary, S., Hong, Y. & Erusalimsky, J. D. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. Journal of cell science 113 (Pt 20), 3613-3622 (2000).
28. Untergasser, G. et al. TGF-cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence. Experimental Gerontology 38, 1179-1188 (2003).
29. Coates, P. J. Markers of senescence? Journal of Pathology 196, 371-373 (2002).
30. Cristofalo, V. J. SA-Gal staining: Biomarker or delusion. Experimental Gerontology 40, 836-838 (2005).
31. Petropoulou, C., Trougakos, I. P., Kolettas, E., Toussaint, O. & Gonos, E. S. Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS letters 509, 287-297 (2001).
32. Kim, K. H. et al. Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is upregulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun 318, 819-825 (2004).
33. Kumazaki, T., Robetorye, R. S., Robetorye, S. C. & Smith, J. R. Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp Cell Res 195, 13-19 (1991).
34. Volonte, D., Zhang, K., Lisanti, M. P. & Galbiati, F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell 13, 2502-2517 (2002).
35. Xiao, F. et al. Role of Mitochondrial Electron Transport Chain Dysfunction in Cr(VI)-Induced Cytotoxicity in L-02 Hepatocytes. Cellular Physiology & Biochemistry 33, 1013-1025 (2014).
36. Fang, X. et al. Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. Molecular & Cellular Biochemistry 371, 65-76 (2012).
37. Nouws, J., Calvaruso, M. A. & Nijtmans, L. The Assembly of Human Complex I, (Springer Netherlands, 2012).
38. Rodenburg, R. J. Mitochondrial complex I- linked disease. Biochimica et Biophysica Acta 1857, 938-945 (2016).
39. Kirby, D. M. et al. NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency. J Clin Invest. Journal of Clinical Investigation 114, 837-845 (2004).
40. Malonia, S. K., Dutta, P., Santra, M. K. & Green, M. R. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53- mediated growth arrest following genotoxic stress. Proceedings of the National Academy of Sciences 112, 8632-8637 (2015).
41. Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13, 1501-1512 (1999).
42. Gross, A., McDonnell, J. M. & Korsmeyer, S. J. BCL-2 family members and the mitochondria in apoptosis. Genes & development 13, 1899-1911 (1999).
43. Miyashita, T., Harigai, M., Hanada, M. & Reed, J. C. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer research 54, 3131-3135 (1994).
44. Alimonti, A. et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. The Journal of clinical investigation 120, 681-693 (2010).
45. Probin, V., Wang, Y. & Zhou, D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med 42, 1858-1865 (2007).
46. De Flora, S. Threshold mechanisms and site specificity in chromium (VI) carcinogenesis. Carcinogenesis 21, 533-541 (2000).