P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitions

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 21412-21421

  Allsopp, Rebecca C ^a   Farmer, Louise K ^a   Fryatt, Alistair G ^a   Evans, Richard J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY;

AMINO TERMINUS; CARBOXYL TERMINUS; CHANNEL OPENING; CHANNEL PROPERTY; CHANNEL TRANSITION; EXTRACELLULAR; OPEN CHANNELS; TRANSMEMBRANES;

RECOVERY;

PURINERGIC P2X RECEPTOR; ADENOSINE TRIPHOSPHATE; PURINERGIC P2X RECEPTOR AGONIST; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PYRIDOXAL 5 PHOSPHATE; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY LABELING; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; CRYSTALLIZATION; DESENSITIZATION; ELECTROPHYSIOLOGY; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; SHEAR STRESS; VOLTAGE CLAMP; ANIMAL; BIOLOGICAL MODEL; CHANNEL GATING; CHEMISTRY; DRUG EFFECTS; EXTRACELLULAR SPACE; HUMAN; INTRACELLULAR SPACE; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TIME; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; EXTRACELLULAR SPACE; HUMANS; INTRACELLULAR SPACE; ION CHANNEL GATING; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PURINERGIC P2X RECEPTOR AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; RECEPTORS, PURINERGIC P2X1; RECEPTORS, PURINERGIC P2X2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; XENOPUS LAEVIS;

EID: 84880552270     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.464651     Document Type: Article

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