Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine

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Volumn 12, Issue 46, 2016, Pages 6353-6362

  Luo, Cong ^a   Sun, Jin ^a   Sun, Bingjun ^a   Liu, Dan ^a   Miao, Lei ^b   Goodwin, Tyler Jay ^b   Huang, Leaf ^b   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

cancer therapy; disulfide bonds; oleate prodrugs; paclitaxel; prodrug nanosystems

Indexed keywords

COVALENT BONDS; DISEASES; DRUG PRODUCTS; MEDICAL NANOTECHNOLOGY; ONCOLOGY; TUMORS;

ANTI-TUMOR EFFICACY; CANCER THERAPY; DISULFIDE BONDS; DOCOSAHEXAENOIC ACID; FACILE FABRICATION; HIGH DRUG LOADINGS; PACLITAXEL; PRODRUGS;

NANOSYSTEMS;

ANTINEOPLASTIC AGENT; DRUG CARRIER; OLEIC ACID; PACLITAXEL; PRODRUG;

ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; NANOMEDICINE; NUDE MOUSE; OXIDATION REDUCTION REACTION; PROCEDURES; RAT; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE, NUDE; NANOMEDICINE; OLEIC ACID; OXIDATION-REDUCTION; PACLITAXEL; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; UTERINE CERVICAL NEOPLASMS;

EID: 84990066679     PISSN: 16136810     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.201601597     Document Type: Article

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