DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

Aging Cell

Volumn 16, Issue 1, 2017, Pages 162-172

  Misiak, Magdalena ^a   Vergara Greeno, Rebeca ^a   Baptiste, Beverly A ^a   Sykora, Peter ^a   Liu, Dong ^a   Cordonnier, Stephanie ^a   Fang, Evandro F ^a   Croteau, Deborah L ^a   Mattson, Mark P ^a   Bohr, Vilhelm A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; DNA damage; DNA polymerase ; DNA repair; neurogenesis; olfactory bulb; smell

Indexed keywords

AMYLOID BETA PROTEIN; DNA DIRECTED DNA POLYMERASE BETA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL METABOLIC RATE; CELL METABOLISM; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; FEMALE; HAPLOINSUFFICIENCY; HETEROZYGOSITY; HETEROZYGOTE; HISTOPATHOLOGY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; MOUSE MODEL; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; SMELLING; SMELLING DISORDER; SUBVENTRICULAR ZONE; TASK PERFORMANCE; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; CELL DEATH; CELL DIFFERENTIATION; CELL RESPIRATION; DISEASE MODEL; ENZYMOLOGY; MAMMALIAN EMBRYO; METABOLISM; MITOCHONDRION; NERVE CELL; ODOR; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELL DEATH; CELL DIFFERENTIATION; CELL RESPIRATION; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA POLYMERASE BETA; EMBRYO, MAMMALIAN; HAPLOINSUFFICIENCY; HETEROZYGOTE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; NEUROGENESIS; NEURONS; OLFACTORY BULB; SMELL;

EID: 84990041242     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12541     Document Type: Article

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