Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism

Toxicology

Volumn 370, Issue , 2016, Pages 116-126

  Su, Hsiang Han ^a   Lin, Hsin Ting ^b   Suen, Jau Ling ^a,b   Sheu, Chau Chyun ^e,f   Yokoyama, Kazunari K ^a,b,c,d   Huang, Shau Ku ^b,g   Cheng, Chih Mei ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^g NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Alpha SMA; Arachidonic acid; Aryl hydrocarbon receptor; Fibrosis; Myocardin related transcription factor

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA SMOOTH MUSCLE ACTIN; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; AROMATIC HYDROCARBON RECEPTOR; CALCIUM; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOSKELETON PROTEIN; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; MYOCARDIN RELATED TRANSCRIPTION FACTOR; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID (2-METHYL-4-O-TOLYLAZOPHENYL)AMIDE; ACTA2 PROTEIN, HUMAN; ACTIN; ALOX5 PROTEIN, HUMAN; ARACHIDONIC ACID DERIVATIVE; AZO COMPOUND; POLYCHLORINATED DIBENZODIOXIN; PTGS2 PROTEIN, HUMAN; PYRAZOLE DERIVATIVE;

ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME INDUCTION; FETUS; GENE SILENCING; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; METABOLIC REGULATION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REPORTER GENE; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; CYTOSKELETON; DRUG EFFECTS; FIBROBLAST; GENETICS; LUNG; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACIDS; AZO COMPOUNDS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CYCLOOXYGENASE 2; CYTOSKELETON; DINOPROSTONE; FIBROBLASTS; GENES, REPORTER; HUMANS; LEUKOTRIENE B4; LUNG; POLYCHLORINATED DIBENZODIOXINS; PROMOTER REGIONS, GENETIC; PYRAZOLES; RECEPTORS, ARYL HYDROCARBON; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84989960563     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.09.019     Document Type: Article

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