2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces calcium influx through T-type calcium channel and enhances lysosomal exocytosis and insulin secretion in INS-1 cells

International Journal of Toxicology

Volumn 28, Issue 3, 2009, Pages 151-161

  Kim, Youn Hee ^a   Shim, Young Jun ^a   Shin, Yong Jae ^a   Sul, Donggeun ^a   Lee, Eunil ^a   Min, Bon Hong ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Exocytosis; Insulin; Lysosomes; T type calcium channel; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BETA N ACETYLHEXOSAMINIDASE; CALCIUM; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; FLUNARIZINE; FORMAZAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MIBEFRADIL; INSULIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DIABETOGENESIS; EXOCYTOSIS; INSULIN RELEASE; LYSOSOME; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; ANIMAL; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; POLLUTANT; SECRETION; TUMOR CELL LINE;

RATTUS;

ANIMALS; CALCIUM; CALCIUM CHANNELS, T-TYPE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; EXOCYTOSIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; LYSOSOMES; RATS; RECEPTORS, ARYL HYDROCARBON; SECRETORY PATHWAY; TETRACHLORODIBENZODIOXIN;

EID: 68849121290     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809336885     Document Type: Article

References (30)

1. Geyer HJ, Scheunert I, Rapp K, et al. The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ecotoxicol Environ Saf. 1993;26(1):45-60.
2. Michalek JE, Pirkle JL, Caudill SP, et al. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J Toxicol Environ Health. 1996; 47(3):209-220.
3. Larsen JC. Risk assessments of polychlorinated dibenzop- dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food. Mol Nutr Food Res. 2006;50(10):885-896.
4. Mandal PK. Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J Comp Physiol [B]. 2005;175(4):221-230.
5. Unkila M, Pohjanvirta R, MacDonald E, Tuomisto J. Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxininduced brain serotonin metabolism in the rat. Eur J Pharmacol. 1994;270(2-3):157-166.
6. Cranmer M, Louie S, Kennedy RH, Kern PA, Fonseca VA. Exposure to 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. Toxicol Sci. 2000;56(2):431-436.
7. Novelli M, Piaggi S, De Tata V. 2,3,7,8-Tetrachlorodibenzo-p-dioxin- induced impairment of glucosestimulated insulin secretion in isolated rat pancreatic islets. Toxicol Lett. 2005;156(2):307-314.
8. Longnecker MP, Michalek JE. Serum dioxin level in relation to diabetes mellitus among Air Force veterans with background levels of exposure. Epidemiology. 2000; 11(1):44-48.
9. Kern PA, Said S, Jackson WG Jr, Michalek JE. Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Clin Endocrinol Metab. 2004;89(9): 4665-4672.
10. Remillard RB, Bunce NJ. Linking dioxins to diabetes: epidemiology and biologic plausibility. Environ Health Perspect. 2002;110(9):853-858.
11. Liu PC, Matsumura F. TCDD suppresses insulinresponsive glucose transporter (GLUT-4) gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes. J Biochem Mol Toxicol. 2006;20(2):79-87.
12. Enan E, Liu PC, Matsumura F. 2,3,7,8- Tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig. J Biol Chem. 1992;267(28):19785-19791.
13. Kern PA, Dicker-Brown A, Said ST, Kennedy R, Fonseca VA. The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Metabolism. 2002;51(1):65-68.
14. Liu Y, Peterson DA, Kimura H, Schubert D. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J Neurochem. 1997; 69(2):581-593.
15. Liu Y, Schubert D. Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis. J Neurochem. 1997;69(6):2285-2293.
16. Dale YR, Eltom SE. Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Mol Pharmacol. 2006;70(5):1481-1487.
17. Karras JG, Morris DL, Matulka RA, Kramer CM, Holsapple MP. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elevates basal B-cell intracellular calcium concentration and suppresses surface Ig- but not CD40-induced antibody secretion. Toxicol Appl Pharmacol. 1996;137(2):275-284.
18. Hanneman WH, Legare ME, Barhoumi R, et al. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology. 1996;112(1):19-28.
19. Canga L, Paroli L, Blanck TJ, Silver RB, Rifkind AB. 2,3,7,8- tetrachlorodibenzo-p-dioxin increases cardiac myocyte intracellular calcium and progressively impairs ventricular contractile responses to isoproterenol and to calcium in chick embryo hearts. Mol Pharmacol. 1993;44(6):1142-1151.
20. 2+ in the MCF- 10A human mammary epithelial cell line by carcinogenic polycyclic aromatic hydrocarbons. Mol Carcinog. 1999;25(1):48-54.
21. 2+)channels. J Membr Biol. 2004;200(2): 57-66.
22. 2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease. Cell Microbiol. 2001;3(4):265-275.
23. Caler EV, Morty RE, Burleigh BA, Andrews NW. Dual role of signaling pathways leading to Ca(2+) and cyclicAMP elevation in host cell invasion by Trypanosoma cruzi. Infect Immun. 2000;68(12):6602-6610.
24. Monteiro P, Gilot D, Le Ferrec E, et al. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/ CaMKIalpha pathway. Mol Pharmacol. 2008;73(3):769-777.
25. Antkiewicz DS, Burns CG, Carney SA, Peterson RE, Heideman W. Heart malformation is an early response to TCDD in embryonic zebrafish. Toxicol Sci. 2005; 84(2):368-377.
26. Pesatori AC, Zocchetti C, Guercilena S, et al. Dioxin exposure and non-malignant health effects: a mortality study. Occup Environ Med. 1998;55(2):126-131.
27. Vena J, Boffetta P, Becher H, et al. Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. Environ Health Perspect. 1998;106 Suppl 2:645-653.
28. Kim JS, Lim HS, Cho SI, Cheong HK, Lim MK. Impact of Agent Orange exposure among Korean Vietnam veterans. Ind Health. 2003;41(3):149-157.
29. Piaggi S, Novelli M, Martino L, et al. Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) in the beta-cell line INS-1E. Toxicol Appl Pharmacol. 2007;220(3):333-340.
30. Bhattacharjee A, Whitehurst RM Jr, Zhang M, Wang L, Li M. T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulinsecreting beta-cell line, INS-1. Endocrinology. 1997; 138(9):3735-3740.