Aryl hydrocarbon receptor-independent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells

Environmental Toxicology

Volumn 27, Issue 9, 2012, Pages 556-562

  Mayati, Abdullah ^a   Le Ferrec, Eric ^a   Lagadic Gossmann, Dominique ^a   Fardel, Olivier ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Aryl hydrocarbon receptor; Benzo(a)pyrene; Calcium; Endothelial cell; Polycyclic aromatic hydrocarbon

Indexed keywords

ARYL HYDROCARBON RECEPTOR; ARYL HYDROCARBONS; BENZO(A)PYRENE; CYTOCHROME P450; INTRACELLULAR CALCIUM CONCENTRATION; POLYCYCLIC AROMATIC HYDROCARBONS(PAHS); TARGET GENES; TOXIC CONTAMINANTS; UP-REGULATION;

CALCIUM; ENVIRONMENTAL REGULATIONS; GENE EXPRESSION; MOLECULAR BIOLOGY; POLYCYCLIC AROMATIC HYDROCARBONS; PYRENE;

ENDOTHELIAL CELLS;

ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BENZO[E]PYRENE; BETA NAPHTHOFLAVONE; CALCIUM ION; CHRYSENE; CYTOCHROME P450 1B1; PYRENE; SMALL INTERFERING RNA;

AROMATIC HYDROCARBON; BIOACCUMULATION; BIOCHEMISTRY; CALCIUM; CONCENTRATION (COMPOSITION); CYTOCHROME; CYTOLOGY; HOMINID; LIGAND; ORGANIC POLLUTANT; PAH; PHYSIOLOGY; PYRENE; TOXICOLOGY;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CHEMICAL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; UPREGULATION;

BENZO(A)PYRENE; BENZOFLAVONES; BETA-NAPHTHOFLAVONE; CALCIUM; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIAL CELLS; ENVIRONMENTAL POLLUTION; GENE KNOCKDOWN TECHNIQUES; HUMANS; RECEPTORS, ARYL HYDROCARBON; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84865079839     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20675     Document Type: Article

References (26)

1. Archuleta MM, Schieven GL, Ledbetter JA, Deanin GG, Burchiel SW. 1993. 7, 12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1, 4, 5-trisphosphate, and mobilization of intracellular calcium. Proc Natl Acad Sci USA 90: 6105-6109.
2. Beischlag TV, Luis Morales J, Hollingshead BD, Perdew GH. 2008. The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr 18: 207-250.
3. Bock KW, Kohle C. 2009. The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver. Biol Chem 390: 1225-1235.
4. Clapp RW, Jacobs MM, Loechler EL. 2008. Environmental and occupational causes of cancer: New evidence 2005-2007. Rev Environ Health 23: 1-37.
5. Curfs DM, Knaapen AM, Pachen DM, Gijbels MJ, Lutgens E, Smook ML, Kockx MM, Daemen MJ, van Schooten FJ. 2005. Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. FASEB J 19: 1290-1292.
6. Davila DR, Davis DP, Campbell K, Cambier JC, Zigmond LA, Burchiel SW. 1995. Role of alterations in Ca(2+)-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J Toxicol Environ Health 45: 101-126.
7. Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. 2005. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7, 8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicol Sci 87: 419-426.
8. Gasiewicz TA, Rucci G. 1991. Alpha-naphthoflavone acts as an antagonist of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor. Mol Pharmacol 40: 607-612.
9. Gong Z, Yang J, Yang M, Wang F, Wei Q, Tanguay RM, Wu T. 2006. Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. Toxicol Lett 166: 229-236.
10. Hankinson O. 1995. The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35: 307-340.
11. Hattemer-Frey HA, Travis CC. 1991. Benzo-a-pyrene: Environmental partitioning and human exposure. Toxicol Ind Health 7: 141-157.
12. Kang JJ, Cheng YW. 1997. Polycyclic aromatic hydrocarbons-induced vasorelaxation through activation of nitric oxide synthase in endothelium of rat aorta. Toxicol Lett 93: 39-45.
13. Kobayashi D, Ahmed S, Ishida M, Kasai S, Kikuchi H. 2009. Calcium/calmodulin signaling elicits release of cytochrome c during 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line. L-MAT. Toxicology 258: 25-32.
14. Korashy HM, El-Kadi AO. 2006. The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases. Drug Metab Rev 38: 411-450.
15. Krieger JA, Davila DR, Lytton J, Born JL, Burchiel SW. 1995. Inhibition of sarcoplasmic/endoplasmic reticulum calcium ATPases (SERCA) by polycyclic aromatic hydrocarbons in HPB-ALL human T cells and other tissues. Toxicol Appl Pharmacol 133: 102-108.
16. Le Ferrec E, Lagadic-Gossmann D, Rauch C, Bardiau C, Maheo K, Massiere F, Le Vee M, Guillouzo A, Morel F. 2002. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. JBiol Chem 277: 24780-24787.
17. Lecureur V, Ferrec EL, N′Diaye M, Vee ML, Gardyn C, Gilot D, Fardel O. 2005. ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Lett 579: 1904-1910.
18. Machala M, Vondracek J, Blaha L, Ciganek M, Neca JV. 2001. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutat Res 497(1-2): 49-62.
19. Monteiro P, Gilot D, Le Ferrec E, Rauch C, Lagadic-Gossmann D, Fardel O. 2008. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol Pharmacol 73: 769-777.
20. N′Diaye M, Le Ferrec E, Lagadic-Gossmann D, Corre S, Gilot D, Lecureur V, Monteiro P, Rauch C, Galibert MD, Fardel O. 2006. Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. J Biol Chem 281: 19906-19915.
21. Omori N, Fukata H, Sato K, Yamazaki K, Aida-Yasuoka K, Takigami H, Kuriyama M, Ichinose M, Mori C. 2007. Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells. Hum Exp Toxicol 26: 811-816.
22. Stevens EA, Mezrich JD, Bradfield CA. 2009. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 127: 299-311.
23. Sugihara K, Okayama T, Kitamura S, Yamashita K, Yasuda M, Miyairi S, Minobe Y, Ohta S. 2008. Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo. Arch Toxicol 82: 5-11.
24. Tannheimer SL, Barton SL, Ethier SP, Burchiel SW. 1997. Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells. Carcinogenesis 18: 1177-1182.
25. Tithof PK, Elgayyar M, Cho Y, Guan W, Fisher AB, Peters-Golden M. 2002. Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J 16: 1463-1464.
26. van Grevenynghe J, Monteiro P, Gilot D, Fest T, Fardel O. 2006. Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons. Biochem Biophys Res Commun 341: 763-769.