Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 40, 2016, Pages E5886-E5895

  Kanda, Satoshi ^a   Yanagitani, Kota ^a,b,c   Yokota, Yukiko ^a   Esaki, Yuta ^a   Kohno, Kenji ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL   (Japan)

Author keywords

SRP; Translational pausing; Translocon; Unfolded protein response; XBP1 mRNA

Indexed keywords

MESSENGER RNA; TRANSLOCON; X BOX BINDING PROTEIN 1; PROTEIN BINDING; SIGNAL RECOGNITION PARTICLE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REGULATORY MECHANISM; RNA SPLICING; RNA TRANSLATION; UNFOLDED PROTEIN RESPONSE; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; INTRACELLULAR MEMBRANE; METABOLISM; NUCLEAR LOCALIZATION SIGNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPLASMIC RETICULUM; HEK293 CELLS; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; MODELS, BIOLOGICAL; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; RNA SPLICING; RNA, MESSENGER; SIGNAL RECOGNITION PARTICLE; SIGNAL TRANSDUCTION; X-BOX BINDING PROTEIN 1;

EID: 84989957603     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604435113     Document Type: Article

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