Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

Science Translational Medicine

Volumn 8, Issue 358, 2016, Pages

  Higgins, Sarah J ^a,b,c   Purcell, Lisa A ^d   Silver, Karlee L ^b,e   Tran, Vanessa ^b   Crowley, Valerie ^b   Hawkes, Michael ^b,f   Conroy, Andrea L ^b   Opoka, Robert O ^g   Hay, John G ^h   Quaggin, Susan E ⁱ   Thurston, Gavin ^d   Liles, W Conrad ^j   Kain, Kevin C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c HARVARD MEDICAL SCHOOL   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

^e Grand Challenges Canada   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

^g MULAGO HOSPITAL   (Uganda)

^h NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ NORTHWESTERN UNIVERSITY   (United States)

^j UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; ARTESUNATE; PLACEBO; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD BRAIN BARRIER; BLOOD VESSEL PARAMETERS; CELL PHENOTYPE; CEREBRAL MALARIA; CHILD; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CONVALESCENCE; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFICACY; EMBRYO; FEMALE; GENE DELETION; GENETIC DIFFERENCE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MOLECULAR DYNAMICS; MONOTHERAPY; MOUSE; NEUROMODULATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIGNAL TRANSDUCTION; SURVIVAL RATE; SURVIVAL TIME; SYSTEMIC INFLAMMATION; UGANDAN; UPREGULATION; VASCULAR INTEGRITY; ADENOVIRIDAE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; INFANT; KAPLAN MEIER METHOD; KINETICS; MALARIA FALCIPARUM; METABOLISM; PATHOLOGY; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; SURVIVAL ANALYSIS; TREATMENT OUTCOME; UGANDA;

ADENOVIRIDAE; ANGIOPOIETIN-1; ANIMALS; ANTIMALARIALS; ARTEMISININS; BLOOD-BRAIN BARRIER; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ENDOTHELIAL CELLS; FEMALE; GENE DELETION; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; KINETICS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MALE; MICE, INBRED C57BL; PHENOTYPE; PLASMODIUM FALCIPARUM; RECEPTOR, TIE-2; RECOMBINANT PROTEINS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; UGANDA;

EID: 84989908039     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaf6812     Document Type: Article

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