Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 40, 2016, Pages E5944-E5951

  Leon, Paul E ^a   He, Wenqian ^a   Mullarkey, Caitlin E ^a   Bailey, Mark J ^a   Miller, Matthew S ^b   Krammer, Florian ^a   Palese, Peter ^a   Tan, Gene S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antibody dependent cell mediated immunity; Broadly reactive antibodies; Fc receptor; Hemagglutinin; Influenza virus

Indexed keywords

EPITOPE; FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY; SIALIC ACID; N ACETYLNEURAMINIC ACID; VIRUS ANTIBODY;

ANTIBODY DEPENDENT CELL MEDIATED IMMUNITY; ANTIBODY RESPONSE; ARTICLE; BINDING SITE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; INFLUENZA VIRUS; MOLECULAR INTERACTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR BINDING; AMINO ACID SEQUENCE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; BIOLOGICAL MODEL; CHEMISTRY; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; EPITOPES; HEK293 CELLS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNITY, CELLULAR; MODELS, BIOLOGICAL; MODELS, MOLECULAR; N-ACETYLNEURAMINIC ACID; ORTHOMYXOVIRIDAE; RECEPTORS, FC;

EID: 84989895227     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1613225113     Document Type: Article

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