Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin

Journal of Virology

Volumn 88, Issue 23, 2014, Pages 13580-13592

  Tan, Gene S ^a   Lee, Peter S ^b,c   Hoffman, Ryan M B ^b   Mazel Sanchez, Beryl ^a   Krammer, Florian ^a   Leon, Paul E ^a   Ward, Andrew B ^b   Wilson, Ian A ^b,c   Palese, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Department of Integrative Structural and Computational Biology ^*  (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 9H10; UNCLASSIFIED DRUG; EPITOPE; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; CELL FREE SYSTEM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; ENDOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IN VITRO STUDY; INFECTION PREVENTION; INFLUENZA A (H3N2); MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN DOMAIN; STRUCTURE ANALYSIS; SURVIVAL RATE; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; ORTHOMYXOVIRIDAE INFECTIONS; PASSIVE IMMUNIZATION; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT OUTCOME; VIRUS ENTRY; VIRUS RELEASE;

INFLUENZA A VIRUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNIZATION, PASSIVE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; ORTHOMYXOVIRIDAE INFECTIONS; TREATMENT OUTCOME; VIRUS INTERNALIZATION; VIRUS RELEASE;

EID: 84911434712     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02289-14     Document Type: Article

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