Association of genetic variants of the α-kinase 1 gene with type 2 diabetes mellitus in a longitudinal population‑based genetic epidemiological study

Biomedical Reports

Volumn 3, Issue 3, 2015, Pages 347-354

  Yamada, Yoshiji ^a,b   Matsui, Kota ^b,c   Takeuchi, Ichiro ^b,c   Oguri, Mitsutoshi ^d   Fujimaki, Tetsuo ^e  

^a MIE UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^d JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

^e Inabe General Hospital   (Japan)

Author keywords

Genetic epidemiology; Genetics; Longitudinal study; Polymorphism; Type 2 diabetes mellitus

Indexed keywords

ALPHA PROTEIN KINASE 1; GENOMIC DNA; HEMOGLOBIN A1C; PROTEIN KINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; GENOTYPING TECHNIQUE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PREVALENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84989894771     PISSN: 20499434     EISSN: 20499442     Source Type: Journal    
DOI: 10.3892/br.2015.439     Document Type: Article

References (45)

1. Stumvoll M, Goldstein BJ and van Haeften TW: Type 2 diabetes: Principles of pathogenesis and therapy. Lancet 365: 1333‑1346, 2005.
2. Shaw JE, Sicree RA and Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4‑14, 2010.
3. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH and Hu FB: Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. JAMA 301: 2129‑2140, 2009.
4. Yang W, Dall TM, Halder P, et al: Economic costs of diabetes in the U.S. in 2012. Diabetes Care 36: 1033‑1046, 2013.
5. Zhang P, Zhang X, Brown J, Vistisen D, Sicree R, Shaw J and Nichols G: Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 293‑301, 2010.
6. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26(Suppl 1): S5‑S20, 2003.
7. Hu FB: Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care 34: 1249‑1257, 2011.
8. Wellcome Trust Case Control Consortium: Genome‑wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661‑678, 2007.
9. Sladek R, Rocheleau G, Rung J, et al: A genome‑wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 881‑885, 2007.
10. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770‑775, 2007.
11. Bouatia‑Naji N, Bonnefond A, Cavalcanti‑Proença C, et al: A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41: 89‑94, 2009.
12. Voight BF, Scott LJ, Steinthorsdottir V, et al: Twelve type 2 diabetes susceptibility loci identified through large‑scale association analysis. Nat Genet 42: 579‑589, 2010.
13. Yasuda K, Miyake K, Horikawa Y, et al: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40: 1092‑1097, 2008.
14. Unoki H, Takahashi A, Kawaguchi T, et al: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40: 1098‑1102, 2008.
15. Yamauchi T, Hara K, Maeda S, et al: A genome‑wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A‑C2CD4B. Nat Genet 42: 864‑868, 2010.
16. Cho YS, Chen CH, Hu C, et al: Meta‑analysis of genome‑wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 44: 67‑72, 2012.
17. Kooner JS, Saleheen D, Sim X, et al: Genome‑wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 43: 984‑989, 2011.
18. Yamada Y, Nishida T, Ichihara S, et al: Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis 215: 145‑152, 2011.
19. Yamada Y, Fuku N, Tanaka M, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome‑wide association study. Atherosclerosis 207: 144‑149, 2009.
20. Yamada Y, Nishida T, Ichihara S, et al: Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome‑wide association study. J Med Genet 50: 410‑418, 2013.
21. Yamada Y, Matsuo H, Segawa T, et al: Assessment of genetic risk for myocardial infarction. Thromb Haemost 96: 220‑227, 2006.
22. Fujimaki T, Kato K, Yoshida T, et al: Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease. Thromb Haemost 101: 963‑968, 2009.
23. Oguri M, Kato K, Yokoi K, et al: Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome. Atherosclerosis 206: 486‑493, 2009.
24. Go AS, Mozaffarian D, Roger VL, et al: Heart disease and stroke statistics ‑ 2014 update: A report from the American Heart Association. Circulation 129: e28‑e292, 2014.
25. Sacco RL, Benjamin EJ, Broderick JP, et al: American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Risk factors. Stroke 28: 1507‑1517, 1997.
26. Yamagata K, Ishida K, Sairenchi T, Takahashi H, Ohba S, Shiigai T, Narita M and Koyama A: Risk factors for chronic kidney disease in a community‑based population: A 10‑year follow‑up study. Kidney Int 71: 159‑166, 2007.
27. Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants with hypertension in a longitudinal population‑based genetic epidemiological study. Int J Mol Med (In press).
28. Shimokata S, Oguri M, Fujimaki T, Horibe H, Kato K and Yamada Y: Association between polymorphisms of the α‑kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals. Biomed Rep 1: 940‑944, 2013.
29. Ueyama C, Horibe H, Fujimaki T, Oguri M, Kato K and Yamada Y: Association of genetic variants of CELSR1 and 3q28 with hypertension in community‑dwelling individuals. Biomed Rep 1: 840‑844, 2013.
30. Oguri M, Fujimaki T, Horibe H, Kato K, Ichihara S and Yamada Y: Association of a polymorphism of BTN2A1 with chronic kidney disease in community‑dwelling individuals. Biomed Rep 1: 868‑872, 2013.
31. Fujimaki T, Horibe H, Oguri M, Kato K and Yamada Y: Association of genetic variants of the α‑kinase 1 gene with myocardial infarction in community‑dwelling individuals. Biomed Rep 2: 127‑131, 2014.
32. Horibe H, Ueyama C, Fujimaki T, Oguri M, Kato K, Ichihara S and Yamada Y: Association of a polymorphism of BTN2A1 with dyslipidemia in community‑dwelling individuals. Mol Med Rep 9: 808‑812, 2014.
33. Murakata Y, Fujimaki T and Yamada Y: Association of a butyrophilin, subfamily 2, member A1 gene polymorphism with hypertension. Biomed Rep 2: 818‑822, 2014.
34. Kuzuya T, Nakagawa S, Satoh J, et al: Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract 55: 65‑85, 2002.
35. Itoh Y, Mizuki N, Shimada T, Azuma F, Itakura M, Kashiwase K, Kikkawa E, Kulski JK, Satake M and Inoko H: High‑throughput DNA typing of HLA‑A, ‑B, ‑C, and ‑DRB1 loci by a PCR‑SSOP‑Luminex method in the Japanese population. Immunogenetics 57: 717‑729, 2005.
36. Hanley JA, Negassa A, Edwardes MD and Forrester JE: Statistical analysis of correlated data using generalized estimating equations: An orientation. Am J Epidemiol 157: 364‑375, 2003.
37. Dean CB and Nielsen JD: Generalized linear mixed models: A review and some extensions. Lifetime Data Anal 13: 497‑512, 2007.
38. Heine M, Cramm‑Behrens CI, Ansari A, Chu HP, Ryazanov AG, Naim HY and Jacob R: Alpha‑kinase 1, a new component in apical protein transport. J Biol Chem 280: 25637‑25643, 2005.
39. Wang SJ, Tu HP, Ko AM, Chiang SL, Chiou SJ, Lee SS, Tsai YS, Lee CP and Ko YC: Lymphocyte α‑kinase is a gout‑susceptible gene involved in monosodium urate monohydrate‑induced inflammatory responses. J Mol Med (Berl) 89: 1241‑1251, 2011.
40. Kahn SE: The relative contributions of insulin resistance and beta‑cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3‑19, 2003.
41. Fukushima M, Usami M, Ikeda M, Nakai Y, Taniguchi A, Matsuura T, Suzuki H, Kurose T, Yamada Y and Seino Y: Insulin secretion and insulin sensitivity at different stages of glucose tolerance: A cross‑sectional study of Japanese type 2 diabetes. Metabolism 53: 831‑835, 2004.
42. Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S and Laakso M: Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects. Diabetes Care 29: 2714-2720, 2006.
43. Olefsky JM and Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246, 2010.
44. Norlin S, Ahlgren U and Edlund H: Nuclear factor-?B activity in ß-cells is required for glucose-stimulated insulin secretion. Diabetes 54: 125-132, 2005.
45. Shriner D, Adeyemo A and Rotimi CN: Joint ancestry and association testing in admixed individuals. PLoS Comput Biol 7: e1002325, 2011