-
1
-
-
77952296118
-
Alpha-1 antitrypsin deficiency
-
Kelly E, Greene CM, Carroll TP, McElvaney NG, O'Neill SJ. Alpha-1 antitrypsin deficiency. Respir Med 2010;104:763-772.
-
(2010)
Respir Med
, vol.104
, pp. 763-772
-
-
Kelly, E.1
Greene, C.M.2
Carroll, T.P.3
McElvaney, N.G.4
O'Neill, S.J.5
-
2
-
-
0024397003
-
Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264-Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion
-
Curiel DT, Chytil A, Courtney M, Crystal RG. Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264-Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion. J Biol Chem 1989;264:10477-10486.
-
(1989)
J Biol Chem
, vol.264
, pp. 10477-10486
-
-
Curiel, D.T.1
Chytil, A.2
Courtney, M.3
Crystal, R.G.4
-
3
-
-
0026755363
-
The mechanism of Z alpha 1-antitrypsin accumulation in the liver
-
Lomas DA, Evans DL, Finch JT, Carrell RW. The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature 1992;357:605-607.
-
(1992)
Nature
, vol.357
, pp. 605-607
-
-
Lomas, D.A.1
Evans, D.L.2
Finch, J.T.3
Carrell, R.W.4
-
4
-
-
84894271236
-
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes
-
Molloy K, Hersh CP, Morris VB, Carroll TP, O'Connor CA, Lasky-Su JA, Greene CM, O'Neill SJ, Silverman EK, McElvaney NG. Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med 2014;189:419-427.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 419-427
-
-
Molloy, K.1
Hersh, C.P.2
Morris, V.B.3
Carroll, T.P.4
O'Connor, C.A.5
Lasky-Su, J.A.6
Greene, C.M.7
O'Neill, S.J.8
Silverman, E.K.9
McElvaney, N.G.10
-
5
-
-
0023898432
-
Molecular basis of alpha-1-antitrypsin deficiency
-
Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 1988;84:13-31.
-
(1988)
Am J Med
, vol.84
, pp. 13-31
-
-
Brantly, M.1
Nukiwa, T.2
Crystal, R.G.3
-
6
-
-
0019963490
-
Alpha 1-antitrypsin deficiency: The radiological features of pulmonary emphysema in subjects of Pi type Z and Pi type SZ: A survey by the British Thoracic Association
-
Gishen P, Saunders AJ, Tobin MJ, Hutchison DC. Alpha 1-antitrypsin deficiency: the radiological features of pulmonary emphysema in subjects of Pi type Z and Pi type SZ: a survey by the British Thoracic Association. Clin Radiol 1982;33:371-377.
-
(1982)
Clin Radiol
, vol.33
, pp. 371-377
-
-
Gishen, P.1
Saunders, A.J.2
Tobin, M.J.3
Hutchison, D.C.4
-
7
-
-
9644295576
-
Pattern of emphysema distribution in α1-antitrypsin deficiency influences lung function impairment
-
Parr DG, Stoel BC, Stolk J, Stockley RA. Pattern of emphysema distribution in α1-antitrypsin deficiency influences lung function impairment. Am J Respir Crit Care Med 2004;170:1172-1178.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 1172-1178
-
-
Parr, D.G.1
Stoel, B.C.2
Stolk, J.3
Stockley, R.A.4
-
8
-
-
0026229834
-
Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency: Spontaneous release of leukotriene B4 by alveolar macrophages
-
Hubbard RC, Fells G, Gadek J, Pacholok S, Humes J, Crystal RG. Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency: spontaneous release of leukotriene B4 by alveolar macrophages. J Clin Invest 1991;88:891-897.
-
(1991)
J Clin Invest
, vol.88
, pp. 891-897
-
-
Hubbard, R.C.1
Fells, G.2
Gadek, J.3
Pacholok, S.4
Humes, J.5
Crystal, R.G.6
-
9
-
-
0034118160
-
Lung neutrophil burden correlates with increased pro-inflammatory cytokines and decreased lung function in individuals with alpha (1) - Antitrypsin deficiency
-
Rouhani F, Paone G, Smith NK, Krein P, Barnes P, Brantly ML. Lung neutrophil burden correlates with increased pro-inflammatory cytokines and decreased lung function in individuals with alpha (1) - antitrypsin deficiency. Chest 2000;117(5 suppl 1):250S-251S.
-
(2000)
Chest
, vol.117
, Issue.5
, pp. 250S-251S
-
-
Rouhani, F.1
Paone, G.2
Smith, N.K.3
Krein, P.4
Barnes, P.5
Brantly, M.L.6
-
10
-
-
32544437550
-
Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects
-
Malerba M, Ricciardolo F, Radaeli A, Torregiani C, Ceriani L, Mori E, Bontempelli M, Tantucci C, Grassi V. Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects. Thorax 2006;61:129-133.
-
(2006)
Thorax
, vol.61
, pp. 129-133
-
-
Malerba, M.1
Ricciardolo, F.2
Radaeli, A.3
Torregiani, C.4
Ceriani, L.5
Mori, E.6
Bontempelli, M.7
Tantucci, C.8
Grassi, V.9
-
11
-
-
2442488539
-
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
-
Mulgrew AT, Taggart CC, Lawless MW, Greene CM, Brantly ML, O'Neill SJ, McElvaney NGZ. Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest 2004;125:1952-1957.
-
(2004)
Chest
, vol.125
, pp. 1952-1957
-
-
Mulgrew, A.T.1
Taggart, C.C.2
Lawless, M.W.3
Greene, C.M.4
Brantly, M.L.5
O'Neill, S.J.6
McElvaney, N.G.Z.7
-
12
-
-
0038018539
-
Neutrophil elastase up-regulates interleukin-8 via Toll-like receptor 4
-
Devaney JM, Greene CM, Taggart CC, Carroll TP, O'Neill SJ, McElvaney NG. Neutrophil elastase up-regulates interleukin-8 via Toll-like receptor 4. FEBS Lett 2003;544:129-132.
-
(2003)
FEBS Lett
, vol.544
, pp. 129-132
-
-
Devaney, J.M.1
Greene, C.M.2
Taggart, C.C.3
Carroll, T.P.4
O'Neill, S.J.5
McElvaney, N.G.6
-
13
-
-
78649816539
-
α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8
-
Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron C, Chotirmall SH, Clynes M, O'Neill SJ, et al. α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. J Clin Invest 2010;120:4236-4250.
-
(2010)
J Clin Invest
, vol.120
, pp. 4236-4250
-
-
Bergin, D.A.1
Reeves, E.P.2
Meleady, P.3
Henry, M.4
McElvaney, O.J.5
Carroll, T.P.6
Condron, C.7
Chotirmall, S.H.8
Clynes, M.9
O'Neill, S.J.10
-
14
-
-
84943526361
-
The BLT1 inhibitory function of α-1 antitrypsin augmentation therapy disrupts leukotriene B4 neutrophil signaling
-
O'Dwyer CA, O'Brien ME, Wormald MR, White MM, Banville N, Hurley K, McCarthy C, McElvaney NG, Reeves EP. The BLT1 inhibitory function of α-1 antitrypsin augmentation therapy disrupts leukotriene B4 neutrophil signaling. J Immunol 2015;195:3628-3641.
-
(2015)
J Immunol
, vol.195
, pp. 3628-3641
-
-
O'Dwyer, C.A.1
O'Brien, M.E.2
Wormald, M.R.3
White, M.M.4
Banville, N.5
Hurley, K.6
McCarthy, C.7
McElvaney, N.G.8
Reeves, E.P.9
-
15
-
-
0018611004
-
Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans
-
Gadek JE, Fells GA, Crystal RG. Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans. Science 1979;206:1315-1316.
-
(1979)
Science
, vol.206
, pp. 1315-1316
-
-
Gadek, J.E.1
Fells, G.A.2
Crystal, R.G.3
-
16
-
-
0000518899
-
Potential mechanism of emphysema: Alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity
-
Carp H, Miller F, Hoidal JR, Janoff A. Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity. Proc Natl Acad Sci USA 1982;79:2041-2045.
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 2041-2045
-
-
Carp, H.1
Miller, F.2
Hoidal, J.R.3
Janoff, A.4
-
17
-
-
0034282683
-
Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity
-
Taggart C, Cervantes-Laurean D, Kim G, McElvaney NG, Wehr N, Moss J, Levine RL. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem 2000;275:27258-27265.
-
(2000)
J Biol Chem
, vol.275
, pp. 27258-27265
-
-
Taggart, C.1
Cervantes-Laurean, D.2
Kim, G.3
McElvaney, N.G.4
Wehr, N.5
Moss, J.6
Levine, R.L.7
-
18
-
-
0023546615
-
Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase
-
Ogushi F, Fells GA, Hubbard RC, Straus SD, Crystal RG. Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase. J Clin Invest 1987;80:1366-1374.
-
(1987)
J Clin Invest
, vol.80
, pp. 1366-1374
-
-
Ogushi, F.1
Fells, G.A.2
Hubbard, R.C.3
Straus, S.D.4
Crystal, R.G.5
-
19
-
-
84904644866
-
Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema
-
Guyot N, Wartelle J, Malleret L, Todorov AA, Devouassoux G, Pacheco Y, Jenne DE, Belaaouaj A. Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema. Am J Pathol 2014;184:2197-2210.
-
(2014)
Am J Pathol
, vol.184
, pp. 2197-2210
-
-
Guyot, N.1
Wartelle, J.2
Malleret, L.3
Todorov, A.A.4
Devouassoux, G.5
Pacheco, Y.6
Jenne, D.E.7
Belaaouaj, A.8
-
20
-
-
0024459145
-
Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis
-
Berger M, Sorensen RU, Tosi MF, Dearborn DG, Döring G. Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis. J Clin Invest 1989;84:1302-1313.
-
(1989)
J Clin Invest
, vol.84
, pp. 1302-1313
-
-
Berger, M.1
Sorensen, R.U.2
Tosi, M.F.3
Dearborn, D.G.4
Döring, G.5
-
21
-
-
0025374923
-
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch
-
Tosi MF, Zakem H, Berger M. Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 1990;86:300-308.
-
(1990)
J Clin Invest
, vol.86
, pp. 300-308
-
-
Tosi, M.F.1
Zakem, H.2
Berger, M.3
-
22
-
-
36849020586
-
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
-
Hartl D, Latzin P, Hordijk P, Marcos V, Rudolph C, Woischnik M, Krauss-Etschmann S, Koller B, Reinhardt D, Roscher AA, et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 2007;13:1423-1430.
-
(2007)
Nat Med
, vol.13
, pp. 1423-1430
-
-
Hartl, D.1
Latzin, P.2
Hordijk, P.3
Marcos, V.4
Rudolph, C.5
Woischnik, M.6
Krauss-Etschmann, S.7
Koller, B.8
Reinhardt, D.9
Roscher, A.A.10
-
23
-
-
84896536402
-
Galectin-9 signaling through TIM-3 is involved in neutrophilmediated Gram-negative bacterial killing: An effect abrogated within the cystic fibrosis lung
-
Vega-Carrascal I, Bergin DA, McElvaney OJ, McCarthy C, Banville N, Pohl K, Hirashima M, Kuchroo VK, Reeves EP, McElvaney NG. Galectin-9 signaling through TIM-3 is involved in neutrophilmediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung. J Immunol 2014;192:2418-2431.
-
(2014)
J Immunol
, vol.192
, pp. 2418-2431
-
-
Vega-Carrascal, I.1
Bergin, D.A.2
McElvaney, O.J.3
McCarthy, C.4
Banville, N.5
Pohl, K.6
Hirashima, M.7
Kuchroo, V.K.8
Reeves, E.P.9
McElvaney, N.G.10
-
24
-
-
79952756344
-
Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways
-
Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J Immunol 2011;186:2897-2909.
-
(2011)
J Immunol
, vol.186
, pp. 2897-2909
-
-
Vega-Carrascal, I.1
Reeves, E.P.2
Niki, T.3
Arikawa, T.4
McNally, P.5
O'Neill, S.J.6
Hirashima, M.7
McElvaney, N.G.8
-
25
-
-
0021239746
-
Proteins of the cystic fibrosis respiratory tract: Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis
-
Fick RB Jr, Naegel GP, Squier SU, Wood RE, Gee JB, Reynolds HY. Proteins of the cystic fibrosis respiratory tract: fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis. J Clin Invest 1984;74:236-248.
-
(1984)
J Clin Invest
, vol.74
, pp. 236-248
-
-
Fick, R.B.1
Naegel, G.P.2
Squier, S.U.3
Wood, R.E.4
Gee, J.B.5
Reynolds, H.Y.6
-
26
-
-
77949329602
-
IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis
-
Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol 2010;184:1642-1652.
-
(2010)
J Immunol
, vol.184
, pp. 1642-1652
-
-
Reeves, E.P.1
Williamson, M.2
Byrne, B.3
Bergin, D.A.4
Smith, S.G.5
Greally, P.6
O'Kennedy, R.7
O'Neill, S.J.8
McElvaney, N.G.9
-
27
-
-
0028129361
-
The effect of neutrophil protenase enzymes on the release of mucus from feline and human airway cultures
-
Lundgren JD, Rieves RD, Mullol J, Logun C, Shelhamer JH. The effect of neutrophil protenase enzymes on the release of mucus from feline and human airway cultures. Respir Med 1994;88:511-518.
-
(1994)
Respir Med
, vol.88
, pp. 511-518
-
-
Lundgren, J.D.1
Rieves, R.D.2
Mullol, J.3
Logun, C.4
Shelhamer, J.H.5
-
29
-
-
8644255162
-
Neutrophil elastase induces mucus cell metaplasia in mouse lung
-
Voynow JA, Fischer BM, Malarkey DE, Burch LH, Wong T, Longphre M, Ho SB, Foster WM. Neutrophil elastase induces mucus cell metaplasia in mouse lung. Am J Physiol Lung Cell Mol Physiol 2004;287:L1293-L1302.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
, pp. L1293-L1302
-
-
Voynow, J.A.1
Fischer, B.M.2
Malarkey, D.E.3
Burch, L.H.4
Wong, T.5
Longphre, M.6
Ho, S.B.7
Foster, W.M.8
-
30
-
-
0036009464
-
Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species
-
Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol 2002;26:447-452.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 447-452
-
-
Fischer, B.M.1
Voynow, J.A.2
-
31
-
-
0033045546
-
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
-
Voynow JA, Young LR, Wang Y, Horger T, Rose MC, Fischer BM. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999;276:L835-L843.
-
(1999)
Am J Physiol
, vol.276
, pp. L835-L843
-
-
Voynow, J.A.1
Young, L.R.2
Wang, Y.3
Horger, T.4
Rose, M.C.5
Fischer, B.M.6
-
32
-
-
0025982378
-
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium
-
Amitani R, Wilson R, Rutman A, Read R, Ward C, Burnett D, Stockley RA, Cole PJ. Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am J Respir Cell Mol Biol 1991;4:26-32.
-
(1991)
Am J Respir Cell Mol Biol
, vol.4
, pp. 26-32
-
-
Amitani, R.1
Wilson, R.2
Rutman, A.3
Read, R.4
Ward, C.5
Burnett, D.6
Stockley, R.A.7
Cole, P.J.8
-
33
-
-
34247588138
-
Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
-
Geraghty P, Rogan MP, Greene CM, Boxio RM, Poiriert T, O'Mahony M, Belaaouaj A, O'Neill SJ, Taggart CC, McElvaney NG. Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression. J Immunol 2007;178:5871-5878.
-
(2007)
J Immunol
, vol.178
, pp. 5871-5878
-
-
Geraghty, P.1
Rogan, M.P.2
Greene, C.M.3
Boxio, R.M.4
Poiriert, T.5
O'Mahony, M.6
Belaaouaj, A.7
O'Neill, S.J.8
Taggart, C.C.9
McElvaney, N.G.10
-
34
-
-
4644263748
-
Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis
-
Rogan MP, Taggart CC, Greene CM, Murphy PG, O'Neill SJ, McElvaney NG. Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis. J Infect Dis 2004;190:1245-1253.
-
(2004)
J Infect Dis
, vol.190
, pp. 1245-1253
-
-
Rogan, M.P.1
Taggart, C.C.2
Greene, C.M.3
Murphy, P.G.4
O'Neill, S.J.5
McElvaney, N.G.6
-
35
-
-
0037768888
-
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins
-
Taggart CC, Greene CM, Smith SG, Levine RL, McCray PB Jr, O'Neill S, McElvaney NG. Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol 2003;171:931-937.
-
(2003)
J Immunol
, vol.171
, pp. 931-937
-
-
Taggart, C.C.1
Greene, C.M.2
Smith, S.G.3
Levine, R.L.4
McCray, P.B.5
O'Neill, S.6
McElvaney, N.G.7
-
36
-
-
0035823570
-
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor
-
Taggart CC, Lowe GJ, Greene CM, Mulgrew AT, O'Neill SJ, Levine RL, McElvaney NG. Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J Biol Chem 2001;276:33345-33352.
-
(2001)
J Biol Chem
, vol.276
, pp. 33345-33352
-
-
Taggart, C.C.1
Lowe, G.J.2
Greene, C.M.3
Mulgrew, A.T.4
O'Neill, S.J.5
Levine, R.L.6
McElvaney, N.G.7
-
37
-
-
76249114693
-
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation
-
Weldon S, McNally P, McElvaney NG, Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, Taggart CC. Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation. J Immunol 2009;183:8148-8156.
-
(2009)
J Immunol
, vol.183
, pp. 8148-8156
-
-
Weldon, S.1
McNally, P.2
McElvaney, N.G.3
Elborn, J.S.4
McAuley, D.F.5
Wartelle, J.6
Belaaouaj, A.7
Levine, R.L.8
Taggart, C.C.9
-
38
-
-
28244437261
-
Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
-
Carroll TP, Greene CM, Taggart CC, Bowie AG, O'Neill SJ, McElvaney NG. Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells. J Immunol 2005;175:7594-7601.
-
(2005)
J Immunol
, vol.175
, pp. 7594-7601
-
-
Carroll, T.P.1
Greene, C.M.2
Taggart, C.C.3
Bowie, A.G.4
O'Neill, S.J.5
McElvaney, N.G.6
-
39
-
-
84907494138
-
Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals
-
Hurley K, Lacey N, O'Dwyer CA, Bergin DA, McElvaney OJ, O'Brien ME, McElvaney OF, Reeves EP, McElvaney NG. Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals. J Immunol 2014;193:3978-3991.
-
(2014)
J Immunol
, vol.193
, pp. 3978-3991
-
-
Hurley, K.1
Lacey, N.2
O'Dwyer, C.A.3
Bergin, D.A.4
McElvaney, O.J.5
O'Brien, M.E.6
McElvaney, O.F.7
Reeves, E.P.8
McElvaney, N.G.9
-
40
-
-
0027156167
-
Impairment of function in aging neutrophils is associated with apoptosis
-
Whyte MK, Meagher LC, MacDermot J, Haslett C. Impairment of function in aging neutrophils is associated with apoptosis. J Immunol 1993;150:5124-5134.
-
(1993)
J Immunol
, vol.150
, pp. 5124-5134
-
-
Whyte, M.K.1
Meagher, L.C.2
MacDermot, J.3
Haslett, C.4
-
41
-
-
0026662491
-
Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes
-
Kilpatrick L, McCawley L, Nachiappan V, Greer W, Majumdar S, Korchak HM, Douglas SD. Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes. J Immunol 1992;149:3059-3065.
-
(1992)
J Immunol
, vol.149
, pp. 3059-3065
-
-
Kilpatrick, L.1
McCawley, L.2
Nachiappan, V.3
Greer, W.4
Majumdar, S.5
Korchak, H.M.6
Douglas, S.D.7
-
42
-
-
0026602386
-
Inhibition of neutrophil superoxide production by human plasma alpha 1-antitrypsin
-
Bucurenci N, Blake DR, Chidwick K, Winyard PG. Inhibition of neutrophil superoxide production by human plasma alpha 1-antitrypsin. FEBS Lett 1992;300:21-24.
-
(1992)
FEBS Lett
, vol.300
, pp. 21-24
-
-
Bucurenci, N.1
Blake, D.R.2
Chidwick, K.3
Winyard, P.G.4
-
43
-
-
84948716818
-
Alpha-1-antitrypsin deficiency panniculitis presenting with severe anasarca, pulmonary embolus and hypogammaglobulinaemia
-
Elsensohn AN, Curtis JA, Secrest AM, Liaqat M, Florell SR, Duffy KL, Edholm K, Summers EM. Alpha-1-antitrypsin deficiency panniculitis presenting with severe anasarca, pulmonary embolus and hypogammaglobulinaemia. Br J Dermatol 2015;173:289-291.
-
(2015)
Br J Dermatol
, vol.173
, pp. 289-291
-
-
Elsensohn, A.N.1
Curtis, J.A.2
Secrest, A.M.3
Liaqat, M.4
Florell, S.R.5
Duffy, K.L.6
Edholm, K.7
Summers, E.M.8
-
44
-
-
84924991278
-
The efficacy and safety of inhaled human α-1 antitrypsin in people with α-1 antitrypsin deficiencyrelated emphysema
-
Franciosi AN, McCarthy C, McElvaney NG. The efficacy and safety of inhaled human α-1 antitrypsin in people with α-1 antitrypsin deficiencyrelated emphysema. Expert Rev Respir Med 2015;9:143-151.
-
(2015)
Expert Rev Respir Med
, vol.9
, pp. 143-151
-
-
Franciosi, A.N.1
McCarthy, C.2
McElvaney, N.G.3
-
45
-
-
0028990371
-
Alpha 1-antitrypsin deficiency and anti-proteinase 3 antibodies in antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis
-
Savige JA, Chang L, Cook L, Burdon J, Daskalakis M, Doery J. Alpha 1-antitrypsin deficiency and anti-proteinase 3 antibodies in antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis. Clin Exp Immunol 1995;100:194-197.
-
(1995)
Clin Exp Immunol
, vol.100
, pp. 194-197
-
-
Savige, J.A.1
Chang, L.2
Cook, L.3
Burdon, J.4
Daskalakis, M.5
Doery, J.6
-
46
-
-
0027336667
-
Alpha 1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis
-
Esnault VL, Testa A, Audrain M, Rogé C, Hamidou M, Barrier JH, Sesboüé R, Martin JP, Lesavre P. Alpha 1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis. Kidney Int 1993;43:1329-1332.
-
(1993)
Kidney Int
, vol.43
, pp. 1329-1332
-
-
Esnault, V.L.1
Testa, A.2
Audrain, M.3
Rogé, C.4
Hamidou, M.5
Barrier, J.H.6
Sesboüé, R.7
Martin, J.P.8
Lesavre, P.9
-
47
-
-
0034979113
-
Anti-proteinase 3 antibody activation of neutrophils can be inhibited by α1-antitrypsin
-
Rooney CP, Taggart C, Coakley R, McElvaney NG, O'Neill SJ. Anti-proteinase 3 antibody activation of neutrophils can be inhibited by α1-antitrypsin. Am J Respir Cell Mol Biol 2001;24:747-754.
-
(2001)
Am J Respir Cell Mol Biol
, vol.24
, pp. 747-754
-
-
Rooney, C.P.1
Taggart, C.2
Coakley, R.3
McElvaney, N.G.4
O'Neill, S.J.5
-
48
-
-
84892546029
-
The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity
-
Bergin DA, Reeves EP, Hurley K, Wolfe R, Jameel R, Fitzgerald S, McElvaney NG. The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity. Sci Transl Med 2014;6:217ra1.
-
(2014)
Sci Transl Med
, vol.6
, pp. 217ra1
-
-
Bergin, D.A.1
Reeves, E.P.2
Hurley, K.3
Wolfe, R.4
Jameel, R.5
Fitzgerald, S.6
McElvaney, N.G.7
-
49
-
-
0025195297
-
Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor
-
Spriggs DR, Sherman ML, Imamura K, Mohri M, Rodriguez C, Robbins G, Kufe DW. Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor. Cancer Res 1990;50:7101-7107.
-
(1990)
Cancer Res
, vol.50
, pp. 7101-7107
-
-
Spriggs, D.R.1
Sherman, M.L.2
Imamura, K.3
Mohri, M.4
Rodriguez, C.5
Robbins, G.6
Kufe, D.W.7
-
50
-
-
0029880123
-
Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells
-
Sato M, Miyazaki T, Nagaya T, Murata Y, Ida N, Maeda K, Seo H. Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells. J Rheumatol 1996;23:432-438.
-
(1996)
J Rheumatol
, vol.23
, pp. 432-438
-
-
Sato, M.1
Miyazaki, T.2
Nagaya, T.3
Murata, Y.4
Ida, N.5
Maeda, K.6
Seo, H.7
-
51
-
-
0032134535
-
Inhibition of TNF-A-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132
-
Fiedler MA, Wernke-Dollries K, Stark JM. Inhibition of TNF-a-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol 1998;19:259-268.
-
(1998)
Am J Respir Cell Mol Biol
, vol.19
, pp. 259-268
-
-
Fiedler, M.A.1
Wernke-Dollries, K.2
Stark, J.M.3
-
52
-
-
0033867906
-
Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases
-
Chikazawa H, Nishiya K, Matsumori A, Hashimoto K. Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases. J Clin Immunol 2000;20:279-286.
-
(2000)
J Clin Immunol
, vol.20
, pp. 279-286
-
-
Chikazawa, H.1
Nishiya, K.2
Matsumori, A.3
Hashimoto, K.4
-
53
-
-
23344445225
-
Anti-lactoferrin antibodies in systemic lupus erythematosus: Isotypes and clinical correlates
-
Caccavo D, Rigon A, Picardi A, Galluzzo S, Vadacca M, Ferri GM, Amoroso A, Afeltra A. Anti-lactoferrin antibodies in systemic lupus erythematosus: isotypes and clinical correlates. Clin Rheumatol 2005;24:381-387.
-
(2005)
Clin Rheumatol
, vol.24
, pp. 381-387
-
-
Caccavo, D.1
Rigon, A.2
Picardi, A.3
Galluzzo, S.4
Vadacca, M.5
Ferri, G.M.6
Amoroso, A.7
Afeltra, A.8
-
54
-
-
0031687630
-
Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis
-
Roozendaal C, Horst G, Pogány K, Van Milligen De Wit AW, Kleibeuker JH, Haagsma EB, Limburg PC, Kallenberg CG. Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis. Adv Exp Med Biol 1998;443:313-319.
-
(1998)
Adv Exp Med Biol
, vol.443
, pp. 313-319
-
-
Roozendaal, C.1
Horst, G.2
Pogány, K.3
Van Milligen De Wit, A.W.4
Kleibeuker, J.H.5
Haagsma, E.B.6
Limburg, P.C.7
Kallenberg, C.G.8
-
55
-
-
33745032125
-
Multi-center study: The biochemical efficacy, safety and tolerability of a new alpha1-proteinase inhibitor, Zemaira
-
Stocks JM, Brantly M, Pollock D, Barker A, Kueppers F, Strange C, Donohue JF, Sandhaus R. Multi-center study: the biochemical efficacy, safety and tolerability of a new alpha1-proteinase inhibitor, Zemaira. COPD 2006;3:17-23.
-
(2006)
COPD
, vol.3
, pp. 17-23
-
-
Stocks, J.M.1
Brantly, M.2
Pollock, D.3
Barker, A.4
Kueppers, F.5
Strange, C.6
Donohue, J.F.7
Sandhaus, R.8
-
56
-
-
31544470902
-
Safety and efficacy of recombinant alpha (1)-antitrypsin therapy in cystic fibrosis
-
Martin SL, Downey D, Bilton D, Keogan MT, Edgar J, Elborn JS; Recombinant AAT CF Study Team. Safety and efficacy of recombinant alpha (1)-antitrypsin therapy in cystic fibrosis. Pediatr Pulmonol 2006;41:177-183.
-
(2006)
Pediatr Pulmonol
, vol.41
, pp. 177-183
-
-
Martin, S.L.1
Downey, D.2
Bilton, D.3
Keogan, M.T.4
Edgar, J.5
Elborn, J.S.6
-
57
-
-
0023148995
-
Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema
-
Wewers MD, Casolaro MA, Sellers SE, Swayze SC, McPhaul KM, Wittes JT, Crystal RG. Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema. N Engl J Med 1987;316:1055-1062.
-
(1987)
N Engl J Med
, vol.316
, pp. 1055-1062
-
-
Wewers, M.D.1
Casolaro, M.A.2
Sellers, S.E.3
Swayze, S.C.4
McPhaul, K.M.5
Wittes, J.T.6
Crystal, R.G.7
-
58
-
-
84922068725
-
Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: Safety, tolerability, and patient outcomes
-
Chotirmall SH, Al-Alawi M, McEnery T, McElvaney NG. Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes. Ther Clin Risk Manag 2015;11:143-151.
-
(2015)
Ther Clin Risk Manag
, vol.11
, pp. 143-151
-
-
Chotirmall, S.H.1
Al-Alawi, M.2
McEnery, T.3
McElvaney, N.G.4
-
59
-
-
67649407825
-
Exploring the role of CT densitometry: A randomised study of augmentation therapy in alpha1-antitrypsin deficiency
-
Dirksen A, Piitulainen E, Parr DG, Deng C, Wencker M, Shaker SB, Stockley RA. Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiency. Eur Respir J 2009;33:1345-1353.
-
(2009)
Eur Respir J
, vol.33
, pp. 1345-1353
-
-
Dirksen, A.1
Piitulainen, E.2
Parr, D.G.3
Deng, C.4
Wencker, M.5
Shaker, S.B.6
Stockley, R.A.7
-
60
-
-
0032724157
-
A randomized clinical trial of a (1)-antitrypsin augmentation therapy
-
Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DC, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, et al. A randomized clinical trial of a (1)-antitrypsin augmentation therapy. Am J Respir Crit Care Med 1999;160:1468-1472.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 1468-1472
-
-
Dirksen, A.1
Dijkman, J.H.2
Madsen, F.3
Stoel, B.4
Hutchison, D.C.5
Ulrik, C.S.6
Skovgaard, L.T.7
Kok-Jensen, A.8
Rudolphus, A.9
Seersholm, N.10
-
61
-
-
70350450961
-
Augmentation therapy for alpha1 antitrypsin deficiency: A metaanalysis
-
Chapman KR, Stockley RA, Dawkins C, Wilkes MM, Navickis RJ. Augmentation therapy for alpha1 antitrypsin deficiency: a metaanalysis. COPD 2009;6:177-184.
-
(2009)
COPD
, vol.6
, pp. 177-184
-
-
Chapman, K.R.1
Stockley, R.A.2
Dawkins, C.3
Wilkes, M.M.4
Navickis, R.J.5
-
62
-
-
84937969384
-
Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): A randomised, double-blind, placebo-controlled trial
-
Chapman KR, Burdon JG, Piitulainen E, Sandhaus RA, Seersholm N, Stocks JM, Stoel BC, Huang L, Yao Z, Edelman JM, et al.; RAPID Trial Study Group. Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial. Lancet 2015;386:360-368.
-
(2015)
Lancet
, vol.386
, pp. 360-368
-
-
Chapman, K.R.1
Burdon, J.G.2
Piitulainen, E.3
Sandhaus, R.A.4
Seersholm, N.5
Stocks, J.M.6
Stoel, B.C.7
Huang, L.8
Yao, Z.9
Edelman, J.M.10
-
63
-
-
84872257169
-
The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency
-
Schmid ST, Koepke J, Dresel M, Hattesohl A, Frenzel E, Perez J, Lomas DA, Miranda E, Greulich T, Noeske S, et al. The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency. Int J Chron Obstruct Pulmon Dis 2012;7:687-696.
-
(2012)
Int J Chron Obstruct Pulmon Dis
, vol.7
, pp. 687-696
-
-
Schmid, S.T.1
Koepke, J.2
Dresel, M.3
Hattesohl, A.4
Frenzel, E.5
Perez, J.6
Lomas, D.A.7
Miranda, E.8
Greulich, T.9
Noeske, S.10
-
64
-
-
0036606880
-
The effect of augmentation therapy on bronchial inflammation in α1-antitrypsin deficiency
-
Stockley RA, Bayley DL, Unsal I, Dowson LJ. The effect of augmentation therapy on bronchial inflammation in α1-antitrypsin deficiency. Am J Respir Crit Care Med 2002;165:1494-1498.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 1494-1498
-
-
Stockley, R.A.1
Bayley, D.L.2
Unsal, I.3
Dowson, L.J.4
-
65
-
-
0023784904
-
Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency
-
Hubbard RC, Sellers S, Czerski D, Stephens L, Crystal RG. Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency. JAMA 1988;260:1259-1264.
-
(1988)
JAMA
, vol.260
, pp. 1259-1264
-
-
Hubbard, R.C.1
Sellers, S.2
Czerski, D.3
Stephens, L.4
Crystal, R.G.5
-
66
-
-
84908087357
-
The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
-
Pini L, Tiberio L, Venkatesan N, Bezzi M, Corda L, Luisetti M, Ferrarotti I, Malerba M, Lomas DA, Janciauskiene S, et al. The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency. Respir Res 2014;15:112.
-
(2014)
Respir Res
, vol.15
, pp. 112
-
-
Pini, L.1
Tiberio, L.2
Venkatesan, N.3
Bezzi, M.4
Corda, L.5
Luisetti, M.6
Ferrarotti, I.7
Malerba, M.8
Lomas, D.A.9
Janciauskiene, S.10
-
67
-
-
72949086203
-
Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization
-
Chang YP, Mahadeva R, Chang WS, Lin SC, Chu YH. Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization. J Cell Mol Med 2009;13:2304-2316.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2304-2316
-
-
Chang, Y.P.1
Mahadeva, R.2
Chang, W.S.3
Lin, S.C.4
Chu, Y.H.5
-
68
-
-
35848929750
-
Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates
-
Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, et al. Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem 2007;50:5357-5363.
-
(2007)
J Med Chem
, vol.50
, pp. 5357-5363
-
-
Mallya, M.1
Phillips, R.L.2
Saldanha, S.A.3
Gooptu, B.4
Brown, S.C.5
Termine, D.J.6
Shirvani, A.M.7
Wu, Y.8
Sifers, R.N.9
Abagyan, R.10
-
69
-
-
0031678410
-
Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis
-
Hull J, Thomson AH. Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis. Thorax 1998;53:1018-1021.
-
(1998)
Thorax
, vol.53
, pp. 1018-1021
-
-
Hull, J.1
Thomson, A.H.2
-
70
-
-
0033953158
-
TNF-alpha and IL-8 in consecutive sputum samples from cystic fibrosis patients during antibiotic treatment
-
Karpati F, Hjelte FL, Wretlind B. TNF-alpha and IL-8 in consecutive sputum samples from cystic fibrosis patients during antibiotic treatment. Scand J Infect Dis 2000;32:75-79.
-
(2000)
Scand J Infect Dis
, vol.32
, pp. 75-79
-
-
Karpati, F.1
Hjelte, F.L.2
Wretlind, B.3
-
71
-
-
33846907545
-
Alpha1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients
-
Griese M, Latzin P, Kappler M, Weckerle K, Heinzlmaier T, Bernhardt T, Hartl D. alpha1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients. Eur Respir J 2007;29:240-250.
-
(2007)
Eur Respir J
, vol.29
, pp. 240-250
-
-
Griese, M.1
Latzin, P.2
Kappler, M.3
Weckerle, K.4
Heinzlmaier, T.5
Bernhardt, T.6
Hartl, D.7
-
72
-
-
46549087438
-
Alpha-1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestations
-
Greene CM, Miller SD, Carroll T, McLean C, O'Mahony M, Lawless MW, O'Neill SJ, Taggart CC, McElvaney NG. Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations. J Inherit Metab Dis 2008;31:21-34.
-
(2008)
J Inherit Metab Dis
, vol.31
, pp. 21-34
-
-
Greene, C.M.1
Miller, S.D.2
Carroll, T.3
McLean, C.4
O'Mahony, M.5
Lawless, M.W.6
O'Neill, S.J.7
Taggart, C.C.8
McElvaney, N.G.9
-
73
-
-
0037789214
-
Inhibition of proteinase 3 by α1-antitrypsin in vitro predicts very fast inhibition in vivo
-
Duranton J, Bieth JG. Inhibition of proteinase 3 by α1-antitrypsin in vitro predicts very fast inhibition in vivo. Am J Respir Cell Mol Biol 2003;29:57-61.
-
(2003)
Am J Respir Cell Mol Biol
, vol.29
, pp. 57-61
-
-
Duranton, J.1
Bieth, J.G.2
|