Inactivation of human β-defensins 2 and 3 by elastolytic cathepsins

Journal of Immunology

Volumn 171, Issue 2, 2003, Pages 931-937

  Taggart, Clifford C ^a   Greene, Catherine M ^a   Smith, Stephen G ^b   Levine, Rodney L ^c   McCray Jr , Paul B ^d   O'Neill, Shane ^a   McElvaney, Noel G ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; CATHEPSIN; CATHEPSIN B; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AIRWAY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; CYSTIC FIBROSIS; EUKARYOTE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNE RESPONSE; LUNG LAVAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PSEUDOMONAS; REGULATORY MECHANISM; RESPIRATORY EPITHELIUM;

EID: 0037768888     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.2.931     Document Type: Article

References (36)

1. Schutte, B. C., and P. B. McCray, Jr. 2002. β-Defensins in lung host defense. Annu. Rev. Physiol. 64:709.
2. Kaiser, V., and G. Diamond. 2000. Expression of mammalian defensin genes. J. Leukocyte Biol. 68:779.
3. Valore, E. V., and T. Ganz. 1992. Posttranslational processing of defensins in immature human myeloid cells. Blood 15:1538.
4. Risso, A. 2000. Leukocyte antimicrobial peptides: multifunctional effector molecules innate immunity. J. Leukocyte Biol. 68:785.
5. Valore, E. V., C. H. Park, A. J. Quayle, K. R. Wiles, P. B. McCray, Jr., and T. Ganz. 1998. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1633.
6. Bals, R., X. Wang, Z. Wu, T. Freeman, V. Bafna, M. Zasloff, and J. M. Wilson. 1998. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102:874.
7. Harder, J., J. Bartels, E. Christophers, and J. M. Schroder. 2001. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:5707.
8. Garcia, J. R., A. Krause, S. Schulz, F. J. Rodriguez-Jimenez, E. Kluver, K. Adermann, U. Forssmann, A. Frimpong-Boateng, R. Bals, and W. G. Forssmann. 2001. Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 15:1819.
9. Schutte, B. C., J. P. Mitros, J. A. Bartlett, J. D. Walters, H. P, Jia, M. J. Welsh, T. L. Casavant, and P. B. McCray, Jr, 2002. Discovery of five conserved β-defensin gene clusters using a computational search strategy. Proc. Natl. Acad. Sci. USA 99:2129.
10. Schroder, J. M. 1999. Epithelial antimicrobial peptides: innate local host response elements. Cell. Mol. Life Sci. 56:32.
11. Zhao, C., I. Wang, and R. I. Lehrer. 1996. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:319.
12. Duits, L. A., B. Ravensbergen, M. Rademaker, P. S. Hiemstra, and P. H. Nibbering. 2002. Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106:517.
13. Mathews, M., H. P. Jia, J. M. Guthmiller, G. Losh, S. Graham, G. K. Johnson, B. F. Tack, and P. B. McCray, Jr. 1999. Production of β-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect. Immun. 67:2740.
14. Harder, J., U. Meyer-Hoffert, L. M. Teran, L. Schwichtenberg, J. Bartels, S. Maune, and J. M. Schroder. 2000. Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6, induce human β-defensin-2 in respiratory epithelia. Am. J. Respir. Cell Mol. Biol. 22:714.
15. Liu, A. Y., D. Destoumieux, A. V. Wong, C. H. Park, E. V. Valore, L. Liu, and T. Ganz. 2002. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J. Invest. Dermatol. 118:275.
16. Garcia, J. R., F. Jaumann, S. Schulz, A. Krause, J. Rodriguez-Jimenez, U. Forssmann, K. Adermann, E. Kluver, C. Vogelmeier, D. Becker, et al. 2001. Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity: its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell. Tissue Res. 306:257.
17. Konstan, M., and M. Berger. 1993. Infection and inflammation of the lung in cystic fibrosis. In Cystic Fibrosis. P. B. Davis, ed. Marcel Dekker, New York, pp. 219-276.
18. Goldman, M. J., G. M. Anderson, E. D. Stolzenberg, U. P. Kari, M. Zasloff, and J. M. Wilson. 1997. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553.
19. Smith, J. J., S. M. Travis, E. P. Greenberg, and M. J. Welsh. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:229.
20. Travis, S. M., B. A. Conway, J. Zabner, J. J. Smith, N. N. Anderson, P. K. Singh, E. P. Greenberg, and M. J. Welsh. 1999. Activity of abundant antimicrobials of the human airway. Am. J. Respir. Cell Mol. Biol. 20:872.
21. Britigan, B. E., M. B. Hayek, B. N. Doebbeling, and R. B. Fick, Jr. 1993. Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fibrosis. Infect. Immun. 61:5049.
22. Jacquot, J., J. M. Toumier, and E. Puchelle. 1985. In vitro evidence that human airway lysozyme is cleaved and inactivated by Pseudomonas aeruginosa elastase and not by human leukocyte elastase. Infect. Immun. 47:555.
23. Taggart, C. C., G. J. Lowe, C. M. Greene, A. T. Mulgrew, S. J. O'Neill, R. L. Levine, and N. G. McElvaney. 2001. Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J. Biol. Chem. 276:33345.
24. Wolters, P. J., and H. A. Chapman. 2001. Importance of lysosomal cysteine proteases in lung disease. Respir. Res. 1:170.
25. Takahashi, H., K. Ishidoh, D. Muno, A. Ohwada, T. Nukiwa, E. Kominami, and S. Kira. 1993. Cathepsin L activity is increased in alveolar macrophages and bronchoalveolar lavage fluid of smokers. Am. Rev. Respir. Dis. 147:1562.
26. Lehrer, R. I., M. Rosenman, S. S. Harwig, R. Jackson, and P. Eisenhauer. 1991. Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137:167.
27. Klech, H., and Pohl, W. 1989. Technical recommendations and guidelines for bronchoalveolar lavage (BAL): report of the European Society for Pneumonology Task Group. Eur. Respir. J. 2:561.
28. Singh, P. K., H. P. Jia, K. Wiles, J. Hesselberth, L. Liu, B. A. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, et al. 1998. Production of β-defensins by human airway epithelia Proc. Natl. Acad. Sci. USA 95:14961.
29. Yang, D., O. Chertov, S. N. Bykovskaia, Q. Chen, M. J. Buffo, J. Shogan, M. Anderson, J. M. Schroder, J. M. Wang, O. M. Howard, et al. 1999. β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525.
30. Hoover, D. M., K. R. Rajashankar, R. Blumenthal, A. Puri, J. J. Oppenheim, O. Chertov, and J. Lubkowski. 2000. The structure of human β-defensin-2 shows evidence of higher order oligomerization. J. Biol. Chem. 275:32911.
31. Sawai, M. V., H. P. Jia, L. Liu, V. Aseyev, J. M. Wiencek, P. B. McCray, Jr., T. Ganz, W. R. Kearney, and B. F. Tack. 2001. The NMR structure of human β-defensin-2 reveals a novel α-helical segment. Biochemistry 40:3810.
32. Hoover, D. M., O. Chertov, and J. Lubkowski. 2001. The structure of human β-defensin-1: new insights into structural properties of β-defensins. J. Biol. Chem. 276:39021.
33. Schibli, D. J., H. N. Hunter, V. Aseyev, T. D, Starner, J. M. Wiencek, P. B. McCray, Jr., B. F. Tack, and H. J. Vogel. 2002. The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J. Biol. Chem. 277:8279.
34. Lah, T. T., M. Hawley, K. L. Rock, and A. L. Goldberg. 1995. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett. 363:85.
35. Zheng, T., Z. Zhu, Z. Wang, R. J. Homer, B. Ma, R. J. Riese, Jr., H. A. Chapman, Jr., S. D. Shapiro, and J. A. Elias. 2000. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 106:1081.
36. Takeyabu, K., T. Betsuyaku, M. Nishimura, A. Yoshioka, M. Tanino, K. Miyamoto, and Y. Kawakami. 1998. Cysteine proteinases and cystatin C in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Eur. Respir. J. 12:1033.