Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

Science Advances

Volumn 2, Issue 5, 2016, Pages

  Baker, Perrin ^a   Hill, Preston J ^b   Snarr, Brendan D ^c,d   Alnabelseya, Noor ^a,e   Pestrak, Matthew J ^b   Lee, Mark J ^c,d,g   Jennings, Laura K ^f   Tam, John ^a   Melnyk, Roman A ^a,e   Parsek, Matthew R ^f   Sheppard, Donald C ^c,d   Wozniak, Daniel J ^b   Howell, P Lynne ^a,e  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b OHIO STATE UNIVERSITY   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF WASHINGTON   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCHEMISTRY; BIOFILMS; BIOSYNTHESIS; ENZYMES; METABOLITES; SCAFFOLDS; SUGARS;

BACTERIAL BIOFILM; BIOFILM BIOMASS; BIOFILM FORMATION; EFFECTIVE CONCENTRATION; EXOPOLYSACCHARIDES; GLYCOSIDE HYDROLASES; ORDERS OF MAGNITUDE; PSEUDOMONAS AERUGINOSA;

HYDROLASES;

ANTIINFECTIVE AGENT; BACTERIAL POLYSACCHARIDE; GLYCOSIDASE;

BIOFILM; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; CYTOTOXICITY; DRUG EFFECTS; ENZYME ACTIVATION; GROWTH, DEVELOPMENT AND AGING; HUMAN; HYDROLYSIS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; NEUTROPHIL; PHYSIOLOGY; PROTEIN DOMAIN; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BIOFILMS; CATALYSIS; CYTOTOXICITY, IMMUNOLOGIC; ENVIRONMENTAL MICROBIOLOGY; ENZYME ACTIVATION; GLYCOSIDE HYDROLASES; HUMANS; HYDROLYSIS; NEUTROPHILS; POLYSACCHARIDES, BACTERIAL; PROTEIN INTERACTION DOMAINS AND MOTIFS; PSEUDOMONAS AERUGINOSA;

EID: 84989302040     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.1501632     Document Type: Article

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