Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide

International Microbiology

Volumn 13, Issue 4, 2010, Pages 207-212

  Khan, Wajiha ^a,b   Bernier, Steve P ^a   Kuchma, Sherry L ^a   Hammond, John H ^a   Hasan, Fariha ^b   O'Toole, George A ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b QUAID I AZAM UNIVERSITY   (Pakistan)

Author keywords

Aminoglycosides; Biofilms; Exopolysaccharides; Minimal bactericidal concentration; Pseudomonas aeruginosa

Indexed keywords

PSEUDOMONAS AERUGINOSA;

EID: 79953165038     PISSN: 11396709     EISSN: 16181905     Source Type: Journal    
DOI: 10.2436/20.1501.01.127     Document Type: Article

References (19)

1. Anderl JN, Franklin MJ, Stewart PS (2000) Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother 44:1818-1824
2. Bertani G (2004) Lysogeny at mid-twentieth century: P1, P2, and other experimental systems. J Bacteriol 186:595-600
3. Caiazza NC, Merritt JH, Brothers KM, O'Toole GA (2007) Inverse regulation of biofilm formation and swarming motility by Pseudomonas aeruginosa PA14. J Bacteriol 189:3603-3612
4. Friedman L, Kolter R (2004) Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms. Mol Microbiol 51:675-690
5. Friedman L, Kolter R (2004) Two genetic loci produce distinct carbohydrate-rich structural components of the Pseudomonas aeruginosa biofilm matrix. J Bacteriol 186:4457-4465
6. Jackson KD, Starkey M, Kremer S, Parsek MR, Wozniak DJ (2004) Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J Bacteriol 186:4466-4475
7. Kolter R (2010) Biofilms in lab and nature: a molecular geneticist's voyage to microbial ecology. Int Microbiol 13:1-7
8. Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA (2007) BifA, a c-di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility in Pseudomonas aeruginosa PA14. J Bacteriol 189:8165-8178
9. Lyczak JB, Cannon CL, Pier GB (2000) Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect 2:1051-1060
10. Ma L, Lu H, Sprinkle A, Parsek MR, Wozniak DJ (2007) Pseudomonas aeruginosa Psl is a galactose-and mannose-rich exopolysaccharide. J Bacteriol 189:8353-8356
11. Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS, O'Toole GA (2003) A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 426:306-310
12. Matsukawa M, Greenberg EP (2004) Putative exopolysaccharide synthesis genes influence Pseudomonas aeruginosa biofilm development. J Bacteriol 186:4449-4456
13. Merritt JH, Brothers KM, Kuchma SL, O'Toole GA (2007) SadC reciprocally influences biofilm formation and swarming motility via modulation of exopolysaccharide production and flagellar function. J Bacteriol 189:8154-8164
14. Merritt JH, Ha DG, Cowles KN, et al. (2010) Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. mBio 1:e00183-10
15. O'Toole GA, Kolter R (1998) Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 30:295-304
16. Parsek MR, Singh PK (2003) Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol 58:677-701
17. Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science 268:1899-1902
18. Shanks RM, Caiazza NC, Hinsa SM, Toutain CM, O'Toole GA (2006) Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria. Appl Environ Microbiol 72: 5027-5036
19. Walters MC 3rd, Roe F, Bugnicourt A, Franklin MJ, Stewart PS (2003) Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin. Antimicrob Agents Chemother 47: 317-323