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Volumn 5, Issue 5, 2015, Pages

Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CEREBLON; DEXAMETHASONE; ENTINOSTAT; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; IMMUNOMODULATING AGENT; LENALIDOMIDE; MYC PROTEIN; ONCOPROTEIN; PANOBINOSTAT; POMALIDOMIDE; RICOLINOSTAT; UNCLASSIFIED DRUG; VORINOSTAT; ANTINEOPLASTIC AGENT; HYDROXAMIC ACID; SMALL INTERFERING RNA; THALIDOMIDE;

EID: 84989285802     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2015.38     Document Type: Article
Times cited : (57)

References (41)
  • 1
    • 77949350034 scopus 로고    scopus 로고
    • Identification of a primary target of thalidomide teratogenicity
    • Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y et al. Identification of a primary target of thalidomide teratogenicity. Science 2010; 327: 1345-1350.
    • (2010) Science , vol.327 , pp. 1345-1350
    • Ito, T.1    Ando, H.2    Suzuki, T.3    Ogura, T.4    Hotta, K.5    Imamura, Y.6
  • 2
    • 80855156719 scopus 로고    scopus 로고
    • Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
    • Zhu YX, Braggio E, Shi CX, Bruins LA, Schmidt JE, Van Wier S et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood 2011; 118: 4771-4779.
    • (2011) Blood , vol.118 , pp. 4771-4779
    • Zhu, Y.X.1    Braggio, E.2    Shi, C.X.3    Bruins, L.A.4    Schmidt, J.E.5    Van Wier, S.6
  • 3
    • 84869082150 scopus 로고    scopus 로고
    • Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
    • Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 2012; 26: 2326-2335.
    • (2012) Leukemia , vol.26 , pp. 2326-2335
    • Lopez-Girona, A.1    Mendy, D.2    Ito, T.3    Miller, K.4    Gandhi, A.K.5    Kang, J.6
  • 4
    • 84892576029 scopus 로고    scopus 로고
    • Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
    • Kronke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 2014; 343: 301-305.
    • (2014) Science , vol.343 , pp. 301-305
    • Kronke, J.1    Udeshi, N.D.2    Narla, A.3    Grauman, P.4    Hurst, S.N.5    McConkey, M.6
  • 5
    • 84892593087 scopus 로고    scopus 로고
    • The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
    • Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science 2014; 343: 305-309.
    • (2014) Science , vol.343 , pp. 305-309
    • Lu, G.1    Middleton, R.E.2    Sun, H.3    Naniong, M.4    Ott, C.J.5    Mitsiades, C.S.6
  • 8
    • 79960220394 scopus 로고    scopus 로고
    • Lenalidomide downregulates the cell survival factor, interferon regulatory factor- 4, providing a potential mechanistic link for predicting response
    • Lopez-Girona A, Heintel D, Zhang LH, Mendy D, Gaidarova S, Brady H et al. Lenalidomide downregulates the cell survival factor, interferon regulatory factor- 4, providing a potential mechanistic link for predicting response. Br J Haematol 2011; 154: 325-336.
    • (2011) Br J Haematol , vol.154 , pp. 325-336
    • Lopez-Girona, A.1    Heintel, D.2    Zhang, L.H.3    Mendy, D.4    Gaidarova, S.5    Brady, H.6
  • 10
    • 84908265816 scopus 로고    scopus 로고
    • Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
    • Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov 2014; 13: 673-691.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 673-691
    • Falkenberg, K.J.1    Johnstone, R.W.2
  • 11
    • 0141593496 scopus 로고    scopus 로고
    • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    • Catley L, Weisberg E, Tai YT, Atadja P, Remiszewski S, Hideshima T et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood 2003; 102: 2615-2622.
    • (2003) Blood , vol.102 , pp. 2615-2622
    • Catley, L.1    Weisberg, E.2    Tai, Y.T.3    Atadja, P.4    Remiszewski, S.5    Hideshima, T.6
  • 13
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • Catley L, Weisberg E, Kiziltepe T, Tai YT, Hideshima T, Neri P et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006; 108: 3441-3449.
    • (2006) Blood , vol.108 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3    Tai, Y.T.4    Hideshima, T.5    Neri, P.6
  • 14
    • 84884703399 scopus 로고    scopus 로고
    • Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): A multicentre, randomised, double-blind study
    • Dimopoulos M, Siegel DS, Lonial S, Qi J, Hajek R, Facon T et al. Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): A multicentre, randomised, double-blind study. Lancet Oncol 2013; 14: 1129-1140.
    • (2013) Lancet Oncol , vol.14 , pp. 1129-1140
    • Dimopoulos, M.1    Siegel, D.S.2    Lonial, S.3    Qi, J.4    Hajek, R.5    Facon, T.6
  • 15
    • 20844435806 scopus 로고    scopus 로고
    • Small molecule inhibition of proteasome and aggresome function induces synergistic anti-tumor activity in multiple myeloma
    • Hideshima H, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL et al. Small molecule inhibition of proteasome and aggresome function induces synergistic anti-tumor activity in multiple myeloma. Proc Natl Acad Sci USA 2005; 102: 8567-8572.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8567-8572
    • Hideshima, H.1    Bradner, J.E.2    Wong, J.3    Chauhan, D.4    Richardson, P.5    Schreiber, S.L.6
  • 16
    • 84858640254 scopus 로고    scopus 로고
    • Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
    • Santo L, Hideshima T, Kung AL, Tseng JC, Tamang D, Yang M et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood 2012; 119: 2579-2589.
    • (2012) Blood , vol.119 , pp. 2579-2589
    • Santo, L.1    Hideshima, T.2    Kung, A.L.3    Tseng, J.C.4    Tamang, D.5    Yang, M.6
  • 17
    • 84893765729 scopus 로고    scopus 로고
    • Induction of differential apoptotic pathways in multiple myeloma cells by class-selective histone deacetylase inhibitors
    • Hideshima T, Mazitschek R, Santo L, Mimura N, Gorgun G, Richardson PG et al. Induction of differential apoptotic pathways in multiple myeloma cells by class-selective histone deacetylase inhibitors. Leukemia 2014; 28: 457-460.
    • (2014) Leukemia , vol.28 , pp. 457-460
    • Hideshima, T.1    Mazitschek, R.2    Santo, L.3    Mimura, N.4    Gorgun, G.5    Richardson, P.G.6
  • 18
    • 84937781015 scopus 로고    scopus 로고
    • Ricolinostat (ACY-1215), a selective HDAC6 inhibitor, in combination with lenalidomide and dexamethasone: Results of a phase 1b trial in relapsed and relapsed refractory multiple myeloma
    • abstract number 4772
    • Yee AJ, Voorhees PM, Bensinger W, Berdeja JG, Supko JG, Richardson PG et al. Ricolinostat (ACY-1215), a selective HDAC6 inhibitor, in combination with lenalidomide and dexamethasone: Results of a phase 1b trial in relapsed and relapsed refractory multiple myeloma. American Society of Hematlogy Annual Meeting. Blood 2014; 124: Abstract number 4772.
    • (2014) American Society of Hematlogy Annual Meeting. Blood , vol.124
    • Yee, A.J.1    Voorhees, P.M.2    Bensinger, W.3    Berdeja, J.G.4    Supko, J.G.5    Richardson, P.G.6
  • 19
    • 84895815366 scopus 로고    scopus 로고
    • Histone deacetylase 3 as a novel therapeutic target in multiple myeloma
    • Minami J, Suzuki R, Mazitschek R, Gorgun G, Ghosh B, Cirstea D et al. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma. Leukemia 2014; 28: 580-690.
    • (2014) Leukemia , vol.28 , pp. 580-690
    • Minami, J.1    Suzuki, R.2    Mazitschek, R.3    Gorgun, G.4    Ghosh, B.5    Cirstea, D.6
  • 20
    • 5144222440 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells
    • Li H, Wu X. Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. Biochem Biophys Res Commun 2004; 324: 860-867.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 860-867
    • Li, H.1    Wu, X.2
  • 21
    • 21644464967 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines
    • Xu Y, Voelter-Mahlknecht S, Mahlknecht U. The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines. Int J Mol Med 2005; 15: 169-172.
    • (2005) Int J Mol Med , vol.15 , pp. 169-172
    • Xu, Y.1    Voelter-Mahlknecht, S.2    Mahlknecht, U.3
  • 22
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, Poulaki V, Tai YT, Chauhan D et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications. Blood 2003; 101: 2377-2380.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3    Poulaki, V.4    Tai, Y.T.5    Chauhan, D.6
  • 23
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007; 7: 585-598.
    • (2007) Nat Rev Cancer , vol.7 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 24
    • 0031918741 scopus 로고    scopus 로고
    • The many roles of c-Myc in apoptosis
    • Thompson EB. The many roles of c-Myc in apoptosis. Annual Rev Physiol 1998; 60: 575-600.
    • (1998) Annual Rev Physiol , vol.60 , pp. 575-600
    • Thompson, E.B.1
  • 25
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: Clinical applications. Blood 2004; 104: 607-618.
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 26
    • 84887579782 scopus 로고    scopus 로고
    • Molecular pathogenesis of multiple myeloma: Basic and clinical updates
    • Chesi M, Bergsagel PL. Molecular pathogenesis of multiple myeloma: Basic and clinical updates. Int J Hematol 2013; 97: 313-323.
    • (2013) Int J Hematol , vol.97 , pp. 313-323
    • Chesi, M.1    Bergsagel, P.L.2
  • 27
    • 0032905924 scopus 로고    scopus 로고
    • C-Myc target genes involved in cell growth, apoptosis, and metabolism
    • Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999; 19: 1-11.
    • (1999) Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 28
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146: 904-917.
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5    Jacobs, H.M.6
  • 29
    • 84921725084 scopus 로고    scopus 로고
    • Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma
    • Moros A, Rodriguez V, Saborit-Villarroya I, Montraveta A, Balsas P, Sandy P et al. Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia 2014; 28: 2049-2059.
    • (2014) Leukemia , vol.28 , pp. 2049-2059
    • Moros, A.1    Rodriguez, V.2    Saborit-Villarroya, I.3    Montraveta, A.4    Balsas, P.5    Sandy, P.6
  • 30
    • 34547652768 scopus 로고    scopus 로고
    • Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia
    • Cheng YC, Lin H, Huang MJ, Chow JM, Lin S, Liu HE. Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Leuk Res 2007; 31: 1403-1411.
    • (2007) Leuk Res , vol.31 , pp. 1403-1411
    • Cheng, Y.C.1    Lin, H.2    Huang, M.J.3    Chow, J.M.4    Lin, S.5    Liu, H.E.6
  • 32
    • 77952306482 scopus 로고    scopus 로고
    • In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma
    • Ocio EM, Vilanova D, Atadja P, Maiso P, Crusoe E, Fernandez-Lazaro D et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica 2010; 95: 794-803.
    • (2010) Haematologica , vol.95 , pp. 794-803
    • Ocio, E.M.1    Vilanova, D.2    Atadja, P.3    Maiso, P.4    Crusoe, E.5    Fernandez-Lazaro, D.6
  • 33
    • 84937797252 scopus 로고    scopus 로고
    • Phase 1B results of ricolinostat (ACY-1215) combination therapy with bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma ( MM). American Society of Hematology Annual Meeting
    • abstract number 4764
    • Vogl DT, Raje N, Hari P, Jones SS, Supko JG, Leone G et al. Phase 1B results of ricolinostat (ACY-1215) combination therapy with bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (MM). American Society of Hematology Annual Meeting. Blood 2014; 124: Abstract number 4764.
    • (2014) Blood , vol.124
    • Vogl, D.T.1    Raje, N.2    Hari, P.3    Jones, S.S.4    Supko, J.G.5    Leone, G.6
  • 34
    • 84904860974 scopus 로고    scopus 로고
    • Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma
    • Zhu YX, Braggio E, Shi CX, Kortuem KM, Bruins LA, Schmidt JE et al. Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma. Blood 2014; 124: 536-545.
    • (2014) Blood , vol.124 , pp. 536-545
    • Zhu, Y.X.1    Braggio, E.2    Shi, C.X.3    Kortuem, K.M.4    Bruins, L.A.5    Schmidt, J.E.6
  • 35
    • 16844379434 scopus 로고    scopus 로고
    • Ikaros transcription factors: Flying between stress and inflammation
    • Chrousos GP, Kino T. Ikaros transcription factors: Flying between stress and inflammation. J Clin Invest 2005; 115: 844-848.
    • (2005) J Clin Invest , vol.115 , pp. 844-848
    • Chrousos, G.P.1    Kino, T.2
  • 36
    • 67149089043 scopus 로고    scopus 로고
    • Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: Therapeutic implications
    • Hideshima T, Chauhan D, Kiziltepe T, Ikeda H, Okawa Y, Podar K et al. Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: Therapeutic implications. Blood 2009; 113: 5228-5236.
    • (2009) Blood , vol.113 , pp. 5228-5236
    • Hideshima, T.1    Chauhan, D.2    Kiziltepe, T.3    Ikeda, H.4    Okawa, Y.5    Podar, K.6
  • 37
    • 77952559263 scopus 로고    scopus 로고
    • A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells
    • Hideshima T, Mitsiades C, Ikeda H, Chauhan D, Raje N, Gorgun G et al. A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells. Blood 2010; 115: 3772-3775.
    • (2010) Blood , vol.115 , pp. 3772-3775
    • Hideshima, T.1    Mitsiades, C.2    Ikeda, H.3    Chauhan, D.4    Raje, N.5    Gorgun, G.6
  • 38
    • 84893289821 scopus 로고    scopus 로고
    • A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma
    • Richardson PG, Xie W, Jagannath S, Jakubowiak A, Lonial S, Raje NS et al. A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. Blood 2014; 123: 1461-1469.
    • (2014) Blood , vol.123 , pp. 1461-1469
    • Richardson, P.G.1    Xie, W.2    Jagannath, S.3    Jakubowiak, A.4    Lonial, S.5    Raje, N.S.6
  • 39
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, Jakubowiak AJ, Jagannath S, Raje NS et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010; 116: 679-686.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3    Jakubowiak, A.J.4    Jagannath, S.5    Raje, N.S.6
  • 40
    • 84895786240 scopus 로고    scopus 로고
    • Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients
    • Nooka AK, Kaufman JL, Muppidi S, Langston A, Heffner LT, Gleason C et al. Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients. Leukemia 2014; 28: 690-693.
    • (2014) Leukemia , vol.28 , pp. 690-693
    • Nooka, A.K.1    Kaufman, J.L.2    Muppidi, S.3    Langston, A.4    Heffner, L.T.5    Gleason, C.6
  • 41
    • 84918551294 scopus 로고    scopus 로고
    • In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-hodgkin lymphoma cells
    • Dasmahapatra G, Patel H, Friedberg J, Quayle SN, Jones SS, Grant S. In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-hodgkin lymphoma cells. Mol Cancer Ther 2014; 13: 2886-2897.
    • (2014) Mol Cancer Ther , vol.13 , pp. 2886-2897
    • Dasmahapatra, G.1    Patel, H.2    Friedberg, J.3    Quayle, S.N.4    Jones, S.S.5    Grant, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.