-
1
-
-
78650408078
-
Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management
-
Rajkumar SV. Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management. Am J Hematol. 2011;86(1):57-65.
-
(2011)
Am J Hematol.
, vol.86
, Issue.1
, pp. 57-65
-
-
Rajkumar, S.V.1
-
2
-
-
0032920883
-
Free radical-mediated oxidative dna damage in the mechanism of thalidomide teratogenicity
-
DOI 10.1038/8466
-
Parman T, Wiley MJ, Wells PG. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat Med. 1999;5(5):582-585. (Pubitemid 29220220)
-
(1999)
Nature Medicine
, vol.5
, Issue.5
, pp. 582-585
-
-
Parman, T.1
Wiley, M.J.2
Wells, P.G.3
-
3
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA. 1994;91(9):4082-4085. (Pubitemid 24139577)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.9
, pp. 4082-4085
-
-
D'Amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
4
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
Ito T, Ando H, Suzuki T, et al. Identification of a primary target of thalidomide teratogenicity. Science. 2010;327(5971):1345-1350.
-
(2010)
Science
, vol.327
, Issue.5971
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
-
5
-
-
70349739288
-
Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
-
Escoubet-Lozach L, Lin IL, Jensen-Pergakes K, et al. Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res. 2009;69(18): 7347-7356.
-
(2009)
Cancer Res.
, vol.69
, Issue.18
, pp. 7347-7356
-
-
Escoubet-Lozach, L.1
Lin, I.L.2
Jensen-Pergakes, K.3
-
6
-
-
47049120726
-
IRF4 addiction in multiple myeloma
-
DOI 10.1038/nature07064, PII NATURE07064
-
Shaffer AL, Emre NC, Lamy L, et al. IRF4 addiction in multiple myeloma. Nature. 2008; 454(7201):226-231. (Pubitemid 351969894)
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 226-231
-
-
Shaffer, A.L.1
Emre, N.C.T.2
Lamy, L.3
Ngo, V.N.4
Wright, G.5
Xiao, W.6
Powell, J.7
Dave, S.8
Yu, X.9
Zhao, H.10
Zeng, Y.11
Chen, B.12
Epstein, J.13
Staudt, L.M.14
-
7
-
-
79960341731
-
Lenalidomide, cyclophosphamide and dexamethasone (CRd) for newly diagnosed multiple myeloma: Results from a phase 2 trial
-
Kumar SK, Lacy MQ, Hayman SR, et al. Lenalidomide, cyclophosphamide and dexamethasone (CRd) for newly diagnosed multiple myeloma: results from a phase 2 trial. Am J Hematol. 2011;86(8):640-645.
-
(2011)
Am J Hematol.
, vol.86
, Issue.8
, pp. 640-645
-
-
Kumar, S.K.1
Lacy, M.Q.2
Hayman, S.R.3
-
8
-
-
79960220394
-
Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response
-
Lopez-Girona A, Heintel D, Zhang LH, et al. Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response. Br J Haematol. 2011;154(3):325-336.
-
(2011)
Br J Haematol.
, vol.154
, Issue.3
, pp. 325-336
-
-
Lopez-Girona, A.1
Heintel, D.2
Zhang, L.H.3
-
9
-
-
80855156719
-
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
-
Zhu YX, Braggio E, Shi CX, et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood. 2011; 118(18):4771-4779.
-
(2011)
Blood
, vol.118
, Issue.18
, pp. 4771-4779
-
-
Zhu, Y.X.1
Braggio, E.2
Shi, C.X.3
-
10
-
-
84869082150
-
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
-
Lopez-Girona A, Mendy D, Ito T, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012;26(11): 2326-2335.
-
(2012)
Leukemia
, vol.26
, Issue.11
, pp. 2326-2335
-
-
Lopez-Girona, A.1
Mendy, D.2
Ito, T.3
-
11
-
-
84873048466
-
High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance
-
Dutch-Belgian HOVON group; German GMMG Group
-
Broyl A, Kuiper R, van Duin M, et al; Dutch-Belgian HOVON group; German GMMG Group. High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance. Blood. 2013;121(4): 624-627.
-
(2013)
Blood
, vol.121
, Issue.4
, pp. 624-627
-
-
Broyl, A.1
Kuiper, R.2
Van Duin, M.3
-
12
-
-
84877807633
-
High expression of cereblon (CRBN) is associated with improved clinical response in patients with multiple myeloma treated with lenalidomide and dexamethasone
-
n/a-n/a
-
Heintel D, Rocci A, Ludwig H, et al. High expression of cereblon (CRBN) is associated with improved clinical response in patients with multiple myeloma treated with lenalidomide and dexamethasone. Br J Haematol. 2013:n/a-n/a.
-
(2013)
Br J Haematol.
-
-
Heintel, D.1
Rocci, A.2
Ludwig, H.3
-
13
-
-
84886898716
-
The myeloma genome in drug refractory extra-medullary disease identifies mutations in proteasome, cereblon and glucocorticoid pathways
-
Egan J, Kortuem KM, Shi C-X, et al. The myeloma genome in drug refractory extra-medullary disease identifies mutations in proteasome, cereblon and glucocorticoid pathways. ASH Annual Meeting Abstracts. 2012;120(21):3968.
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 3968
-
-
Egan, J.1
Kortuem, K.M.2
Shi, C.-X.3
-
14
-
-
84892409192
-
Widespread genetic heterogeneity in multiple myeloma: Implications for targeted therapy
-
Multiple Myeloma Research Consortium
-
Lohr JG, Stojanov P, Carter SL, et al; Multiple Myeloma Research Consortium. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014;25(1):91-101.
-
(2014)
Cancer Cell
, vol.25
, Issue.1
, pp. 91-101
-
-
Lohr, J.G.1
Stojanov, P.2
Carter, S.L.3
-
15
-
-
84890565990
-
The clinical significance of cereblon expression in multiple myeloma
-
Schuster SR, Kortuem KM, Zhu YX, et al. The clinical significance of cereblon expression in multiple myeloma. Leuk Res. 2014;38(1):23-28.
-
(2014)
Leuk Res.
, vol.38
, Issue.1
, pp. 23-28
-
-
Schuster, S.R.1
Kortuem, K.M.2
Zhu, Y.X.3
-
16
-
-
84879525759
-
A miRNA risk score for the prediction of response to lenalidomide in multiple myeloma (MM) patients
-
Neri P, Belch AR, Johnson J, et al. A miRNA risk score for the prediction of response to lenalidomide in multiple myeloma (MM) patients. ASH Annual Meeting Abstracts. 2011;118(21): 987.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 987
-
-
Neri, P.1
Belch, A.R.2
Johnson, J.3
-
17
-
-
84892576029
-
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
-
Krönke J, Udeshi ND, Narla A, et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014; 343(6168):301-305.
-
(2014)
Science
, vol.343
, Issue.6168
, pp. 301-305
-
-
Krönke, J.1
Udeshi, N.D.2
Narla, A.3
-
18
-
-
84892593087
-
The myeloma drug lenalidomide promotes the cereblondependent destruction of Ikaros proteins
-
Lu G, Middleton RE, Sun H, et al. The myeloma drug lenalidomide promotes the cereblondependent destruction of Ikaros proteins. Science. 2014;343(6168):305-309.
-
(2014)
Science
, vol.343
, Issue.6168
, pp. 305-309
-
-
Lu, G.1
Middleton, R.E.2
Sun, H.3
-
19
-
-
77949900421
-
Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6
-
Tiedemann RE, Zhu YX, Schmidt J, et al. Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. Blood. 2010;115(8):1594-1604.
-
(2010)
Blood
, vol.115
, Issue.8
, pp. 1594-1604
-
-
Tiedemann, R.E.1
Zhu, Y.X.2
Schmidt, J.3
-
20
-
-
0034617097
-
Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1
-
DOI 10.1074/jbc.M001109200
-
Hou Y, Cui L, Riordan JR, Chang X. Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1. J Biol Chem. 2000; 275(27):20280-20287. (Pubitemid 30457601)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.27
, pp. 20280-20287
-
-
Hou, Y.-X.1
Cui, L.2
Riordan, J.R.3
Chang, X.-B.4
-
21
-
-
0030689692
-
ATPase activity of purified multidrug resistance-associated protein
-
DOI 10.1074/jbc.272.49.30962
-
Chang XB, Hou YX, Riordan JR. ATPase activity of purified multidrug resistance-associated protein. J Biol Chem. 1997;272(49):30962-30968. (Pubitemid 27527540)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.49
, pp. 30962-30968
-
-
Chang, X.-B.1
Hou, Y.-X.2
Riordan, J.R.3
-
22
-
-
0032571334
-
-
published erratum appears in Mar 27
-
published erratum appears in J Biol Chem 1998 Mar 27;273(13):7782
-
(1998)
J Biol Chem
, vol.273
, Issue.13
, pp. 7782
-
-
-
23
-
-
77952310528
-
A human functional protein interaction network and its application to cancer data analysis
-
Wu G, Feng X, Stein L. A human functional protein interaction network and its application to cancer data analysis. Genome Biol. 2010;11(5): R53.
-
(2010)
Genome Biol.
, vol.11
, Issue.5
-
-
Wu, G.1
Feng, X.2
Stein, L.3
-
24
-
-
73849086725
-
Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
-
Lacy MQ, Hayman SR, Gertz MA, et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J Clin Oncol. 2009;27(30):5008-5014.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.30
, pp. 5008-5014
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
25
-
-
78149468560
-
Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
-
Lacy MQ, Hayman SR, Gertz MA, et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia. 2010;24(11): 1934-1939.
-
(2010)
Leukemia
, vol.24
, Issue.11
, pp. 1934-1939
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
26
-
-
58249097191
-
Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma
-
Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 2009;23(1):3-9.
-
(2009)
Leukemia
, vol.23
, Issue.1
, pp. 3-9
-
-
Kyle, R.A.1
Rajkumar, S.V.2
-
29
-
-
34147129816
-
Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
-
DOI 10.1182/blood-2006-09-044974
-
Mulligan G, Mitsiades C, Bryant B, et al. Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib. Blood. 2007;109(8):3177-3188. (Pubitemid 46572502)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3177-3188
-
-
Mulligan, G.1
Mitsiades, C.2
Bryant, B.3
Zhan, F.4
Chng, W.J.5
Roels, S.6
Koenig, E.7
Fergus, A.8
Huang, Y.9
Richardson, P.10
Trepicchio, W.L.11
Broyl, A.12
Sonneveld, P.13
Shaughnessy Jr., J.D.14
Bergsagel, P.L.15
Schenkein, D.16
Esseltine, D.-L.17
Boral, A.18
Anderson, K.C.19
-
30
-
-
0033103374
-
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
-
Kim J, Sif S, Jones B, et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999;10(3): 345-355. (Pubitemid 29165289)
-
(1999)
Immunity
, vol.10
, Issue.3
, pp. 345-355
-
-
Kim, J.1
Sif, S.2
Jones, B.3
Jackson, A.4
Koipally, J.5
Heller, E.6
Winandy, S.7
Viel, A.8
Sawyer, A.9
Ikeda, T.10
Kingston, R.11
Georgopoulos, K.12
-
31
-
-
0030972497
-
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiatisn
-
DOI 10.1093/emboj/16.8.2004
-
Morgan B, Sun L, Avitahl N, et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997;16(8):2004-2013. (Pubitemid 27170961)
-
(1997)
EMBO Journal
, vol.16
, Issue.8
, pp. 2004-2013
-
-
Morgan, B.1
Sun, L.2
Avitahl, N.3
Andrikopoulos, K.4
Ikeda, T.5
Gonzales, E.6
Wu, P.7
Neben, S.8
Georgopoulos, K.9
-
32
-
-
0030044364
-
The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
-
Molnár A, Wu P, Largespada DA, et al. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol. 1996;156(2):585-592. (Pubitemid 26028917)
-
(1996)
Journal of Immunology
, vol.156
, Issue.2
, pp. 585-592
-
-
Molnar, A.1
Wu, P.2
Largespada, D.A.3
Vortkamp, A.4
Scherer, S.5
Copeland, N.G.6
Jenkins, N.A.7
Bruns, G.8
Georgopoulos, K.9
-
33
-
-
34548271719
-
Combinatorial effects of splice variants modulate function of Aiolos
-
DOI 10.1242/jcs.007344
-
Caballero R, Setien F, Lopez-Serra L, et al. Combinatorial effects of splice variants modulate function of Aiolos. J Cell Sci. 2007;120(Pt 15): 2619-2630. (Pubitemid 47323870)
-
(2007)
Journal of Cell Science
, vol.120
, Issue.15
, pp. 2619-2630
-
-
Caballero, R.1
Setien, F.2
Lopez-Serra, L.3
Boix-Chornet, M.4
Fraga, M.F.5
Ropero, S.6
Megias, D.7
Alaminos, M.8
Sanchez-Tapia, E.M.9
Montoya, M.C.10
Esteller, M.11
Gonzalez-Sarmiento, R.12
Ballestar, E.13
-
34
-
-
0035660607
-
Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene
-
DOI 10.1002/1521-4141(200112) 31:12<3469::AID-IMMU3469>3.0.CO;2-G
-
Liippo J, Nera KP, Veistinen E, et al. Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. Eur J Immunol. 2001;31(12):3469-3474. (Pubitemid 34030959)
-
(2001)
European Journal of Immunology
, vol.31
, Issue.12
, pp. 3469-3474
-
-
Liippo, J.1
Nera, K.-P.2
Veistinen, E.3
Lahdesmaki, A.4
Postila, V.5
Kimby, E.6
Riikonen, P.7
Hammarstrom, L.8
Pelkonen, J.9
Lassila, O.10
-
35
-
-
69849112542
-
Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia
-
Copland M. Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia. Future Oncol. 2009;5(4):455-458.
-
(2009)
Future Oncol.
, vol.5
, Issue.4
, pp. 455-458
-
-
Copland, M.1
-
36
-
-
84873571191
-
Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations
-
Dupuis A, Gaub MP, Legrain M, et al. Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations. Leukemia. 2013;27(2): 503-507.
-
(2013)
Leukemia
, vol.27
, Issue.2
, pp. 503-507
-
-
Dupuis, A.1
Gaub, M.P.2
Legrain, M.3
-
37
-
-
84881668584
-
High frequency of IKZF1 genetic alterations in adult patients with B-cell acute lymphoblastic leukemia
-
Tokunaga K, Yamaguchi S, Iwanaga E, et al. High frequency of IKZF1 genetic alterations in adult patients with B-cell acute lymphoblastic leukemia. Eur J Haematol. 2013;91(3):201-208.
-
(2013)
Eur J Haematol.
, vol.91
, Issue.3
, pp. 201-208
-
-
Tokunaga, K.1
Yamaguchi, S.2
Iwanaga, E.3
-
38
-
-
58149099246
-
The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia
-
Nückel H, Frey UH, Sellmann L, Collins CH, Dührsen U, Siffert W. The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia. Br J Haematol. 2009;144(2):268-270.
-
(2009)
Br J Haematol.
, vol.144
, Issue.2
, pp. 268-270
-
-
Nückel, H.1
Frey, U.H.2
Sellmann, L.3
Collins, C.H.4
Dührsen, U.5
Siffert, W.6
-
39
-
-
84867843856
-
Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4
-
Lee KM, Lee J, Park CS. Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4. Biochem Biophys Res Commun. 2012;427(3):618-622.
-
(2012)
Biochem Biophys Res Commun.
, vol.427
, Issue.3
, pp. 618-622
-
-
Lee, K.M.1
Lee, J.2
Park, C.S.3
-
40
-
-
0034595985
-
BSAP (Pax5)-importin α1 (Rch1) interaction identifies a nuclear localization sequence
-
DOI 10.1074/jbc.M001551200
-
Kovac CR, Emelyanov A, Singh M, Ashouian N, Birshtein BK. BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence. J Biol Chem. 2000;275(22): 16752-16757. (Pubitemid 30398907)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.22
, pp. 16752-16757
-
-
Kovac, C.R.1
Emelyanov, A.2
Singh, M.3
Ashouian, N.4
Birshtein, B.K.5
|