-
1
-
-
70350464482
-
Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells
-
Ndlovu MN, Van Lint C, Van Wesemael K et al. Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol Cell Biol 2009; 29: 5488-504.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5488-5504
-
-
Ndlovu, M.N.1
Van Lint, C.2
Van Wesemael, K.3
-
2
-
-
54749130365
-
Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo
-
Stan SD, Hahm ER, Warin R, Singh SV. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res 2008; 68: 7661-9.
-
(2008)
Cancer Res
, vol.68
, pp. 7661-7669
-
-
Stan, S.D.1
Hahm, E.R.2
Warin, R.3
Singh, S.V.4
-
3
-
-
33846436451
-
Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells
-
Srinivasan S, Ranga RS, Burikhanov R, Han SS, Chendil D. Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res 2007; 67: 246-53.
-
(2007)
Cancer Res
, vol.67
, pp. 246-253
-
-
Srinivasan, S.1
Ranga, R.S.2
Burikhanov, R.3
Han, S.S.4
Chendil, D.5
-
4
-
-
73949113574
-
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis
-
Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C. Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. Mol Cancer Ther 2010; 9: 202-10.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 202-210
-
-
Koduru, S.1
Kumar, R.2
Srinivasan, S.3
Evers, M.B.4
Damodaran, C.5
-
5
-
-
71549153791
-
Withaferin A targets heat shock protein 90 in pancreatic cancer cells
-
Yu Y, Hamza A, Zhang T et al. Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol 2010; 79: 542-51.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 542-551
-
-
Yu, Y.1
Hamza, A.2
Zhang, T.3
-
6
-
-
70149089441
-
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation
-
Shah N, Kataria H, Kaul SC, Ishii T, Kaur G, Wadhwa R. Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation. Cancer Sci 2009; 100: 1740-7.
-
(2009)
Cancer Sci
, vol.100
, pp. 1740-1747
-
-
Shah, N.1
Kataria, H.2
Kaul, S.C.3
Ishii, T.4
Kaur, G.5
Wadhwa, R.6
-
7
-
-
55949092309
-
Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells
-
Stan SD, Zeng Y, Singh SV. Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells. Nutr Cancer 2008; 60(Suppl. 1): 51-60.
-
(2008)
Nutr Cancer
, vol.60
, Issue.SUPPL. 1
, pp. 51-60
-
-
Stan, S.D.1
Zeng, Y.2
Singh, S.V.3
-
8
-
-
56349141560
-
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
-
Mandal C, Dutta A, Mallick A et al. Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 2008; 13: 1450-64.
-
(2008)
Apoptosis
, vol.13
, pp. 1450-1464
-
-
Mandal, C.1
Dutta, A.2
Mallick, A.3
-
9
-
-
73649103765
-
AACR-NCI-EORTC-21st International Symposium. Molecular targets and cancer therapeutics-Part 1
-
Walker K, Padhiar M. AACR-NCI-EORTC-21st International Symposium. Molecular targets and cancer therapeutics-Part 1. I Drugs 2010; 13: 7-9.
-
(2010)
I Drugs
, vol.13
, pp. 7-9
-
-
Walker, K.1
Padhiar, M.2
-
10
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956; 123: 309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
11
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321: 1807-12.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
12
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361: 1058-66.
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
13
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao S, Lin Y, Xu W et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009; 324: 261-5.
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
-
14
-
-
77953702324
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2010; 465: 966.
-
(2010)
Nature
, vol.465
, pp. 966
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
15
-
-
58149340242
-
Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state
-
Hail N Jr., Lotan R. Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state. Mol Nutr Food Res 2009; 53: 49-67.
-
(2009)
Mol Nutr Food Res
, vol.53
, pp. 49-67
-
-
Hail Jr., N.1
Lotan, R.2
-
16
-
-
84864315761
-
IDH1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of MnSOD
-
Robbins D, Wittwer JA, Codarin S et al. IDH1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of MnSOD. Cancer Sci 2012; 103: 1429-33.
-
(2012)
Cancer Sci
, vol.103
, pp. 1429-1433
-
-
Robbins, D.1
Wittwer, J.A.2
Codarin, S.3
-
17
-
-
0037259650
-
Detection of the content and activity of the transcription factor AP-1 in a multistage skin carcinogenesis model
-
Zhao Y, St Clair DK. Detection of the content and activity of the transcription factor AP-1 in a multistage skin carcinogenesis model. Methods Mol Biol 2003; 218: 177-84.
-
(2003)
Methods Mol Biol
, vol.218
, pp. 177-184
-
-
Zhao, Y.1
St Clair, D.K.2
-
18
-
-
0035881315
-
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model
-
Zhao Y, Xue Y, Oberley TD et al. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res 2001; 61: 6082-8.
-
(2001)
Cancer Res
, vol.61
, pp. 6082-6088
-
-
Zhao, Y.1
Xue, Y.2
Oberley, T.D.3
-
19
-
-
38949121664
-
Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis
-
Circu ML, Rodriguez C, Maloney R, Moyer MP, Aw TY. Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis. Free Radic Biol Med 2008; 44: 768-78.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 768-778
-
-
Circu, M.L.1
Rodriguez, C.2
Maloney, R.3
Moyer, M.P.4
Aw, T.Y.5
-
20
-
-
0029781555
-
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
-
Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 1996; 98: 1253-60.
-
(1996)
J Clin Invest
, vol.98
, pp. 1253-1260
-
-
Yen, H.C.1
Oberley, T.D.2
Vichitbandha, S.3
Ho, Y.S.4
St Clair, D.K.5
-
21
-
-
33644922338
-
Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions
-
Zhao Y, Wang LM, Chaiswing L et al. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radic Biol Med 2006; 40: 1234-41.
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 1234-1241
-
-
Zhao, Y.1
Wang, L.M.2
Chaiswing, L.3
-
22
-
-
0018682173
-
Tumour promoter induces anchorage independence irreversibly
-
Colburn NH, Former BF, Nelson KA, Yuspa SH. Tumour promoter induces anchorage independence irreversibly. Nature 1979; 281: 589-91.
-
(1979)
Nature
, vol.281
, pp. 589-591
-
-
Colburn, N.H.1
Former, B.F.2
Nelson, K.A.3
Yuspa, S.H.4
-
23
-
-
80052589800
-
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells
-
Wittwer JA, Robbins D, Wang F et al. Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells. Cancer Prev Res (Phila) 2011; 4: 1476-84.
-
(2011)
Cancer Prev Res (Phila)
, vol.4
, pp. 1476-1484
-
-
Wittwer, J.A.1
Robbins, D.2
Wang, F.3
-
24
-
-
61849177594
-
Effect of withaferin A on the development and decay of thermotolerance in B16F1 melanoma: a preliminary study
-
Kalthur G, Mutalik S, Pathirissery UD. Effect of withaferin A on the development and decay of thermotolerance in B16F1 melanoma: a preliminary study. Integr Cancer Ther 2009; 8: 93-7.
-
(2009)
Integr Cancer Ther
, vol.8
, pp. 93-97
-
-
Kalthur, G.1
Mutalik, S.2
Pathirissery, U.D.3
-
25
-
-
56349123756
-
Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation
-
Oh JH, Lee TJ, Kim SH et al. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis 2008; 13: 1494-504.
-
(2008)
Apoptosis
, vol.13
, pp. 1494-1504
-
-
Oh, J.H.1
Lee, T.J.2
Kim, S.H.3
-
26
-
-
34250346795
-
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin
-
Bargagna-Mohan P, Hamza A, Kim YE et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol 2007; 14: 623-34.
-
(2007)
Chem Biol
, vol.14
, pp. 623-634
-
-
Bargagna-Mohan, P.1
Hamza, A.2
Kim, Y.E.3
-
27
-
-
51049098983
-
Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
-
Kang NJ, Lee KW, Lee DE et al. Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. J Biol Chem 2008; 283: 20664-73.
-
(2008)
J Biol Chem
, vol.283
, pp. 20664-20673
-
-
Kang, N.J.1
Lee, K.W.2
Lee, D.E.3
-
28
-
-
33646531810
-
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
-
Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fassler R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell 2006; 125: 665-77.
-
(2006)
Cell
, vol.125
, pp. 665-677
-
-
Massoumi, R.1
Chmielarska, K.2
Hennecke, K.3
Pfeifer, A.4
Fassler, R.5
-
29
-
-
0022254467
-
Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts
-
Salo T, Turpeenniemi-Hujanen T, Tryggvason K. Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts. J Biol Chem 1985; 260: 8526-31.
-
(1985)
J Biol Chem
, vol.260
, pp. 8526-8531
-
-
Salo, T.1
Turpeenniemi-Hujanen, T.2
Tryggvason, K.3
-
30
-
-
68549094347
-
Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer
-
Guzinska-Ustymowicz K, Pryczynicz A, Kemona A, Czyzewska J. Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Res 2009; 29: 3049-52.
-
(2009)
Anticancer Res
, vol.29
, pp. 3049-3052
-
-
Guzinska-Ustymowicz, K.1
Pryczynicz, A.2
Kemona, A.3
Czyzewska, J.4
-
32
-
-
0036738640
-
AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model
-
Suzukawa K, Weber TJ, Colburn NH. AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ Health Perspect 2002; 110: 865-70.
-
(2002)
Environ Health Perspect
, vol.110
, pp. 865-870
-
-
Suzukawa, K.1
Weber, T.J.2
Colburn, N.H.3
-
33
-
-
36349031033
-
Activation of epidermal akt by diverse mouse skin tumor promoters
-
Lu J, Rho O, Wilker E, Beltran L, Digiovanni J. Activation of epidermal akt by diverse mouse skin tumor promoters. Mol Cancer Res 2007; 5: 1342-52.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1342-1352
-
-
Lu, J.1
Rho, O.2
Wilker, E.3
Beltran, L.4
Digiovanni, J.5
-
34
-
-
0035886843
-
Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates
-
Parrella P, Xiao Y, Fliss M et al. Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res 2001; 61: 7623-6.
-
(2001)
Cancer Res
, vol.61
, pp. 7623-7626
-
-
Parrella, P.1
Xiao, Y.2
Fliss, M.3
-
35
-
-
0031736203
-
Somatic mutations of the mitochondrial genome in human colorectal tumours
-
Polyak K, Li Y, Zhu H et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998; 20: 291-3.
-
(1998)
Nat Genet
, vol.20
, pp. 291-293
-
-
Polyak, K.1
Li, Y.2
Zhu, H.3
-
36
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
-
King A, Selak MA, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 2006; 25: 4675-82.
-
(2006)
Oncogene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
37
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009; 360: 765-73.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
38
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006; 9: 425-34.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
39
-
-
77952737658
-
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
-
Weinberg F, Hamanaka R, Wheaton WW et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A 2010; 107: 8788-93.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
Hamanaka, R.2
Wheaton, W.W.3
-
40
-
-
70350706093
-
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology
-
Lu Z, Scott I, Webster BR, Sack MN. The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res 2009; 105: 830-41.
-
(2009)
Circ Res
, vol.105
, pp. 830-841
-
-
Lu, Z.1
Scott, I.2
Webster, B.R.3
Sack, M.N.4
|