Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamicin-Induced Nephrotoxicity in Rats

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 21, Issue 4, 2016, Pages NP49-NP55

  Ghaznavi, Habib ^a   Mehrzadi, Saeed ^b   Dormanesh, Banafshe ^c   Tabatabaei, Seyyed Mohammad Taghi Hosseini ^d   Vahedi, Habib ^e   Hosseinzadeh, Azam ^b   Pazoki Toroudi, HamidReza ^f   Rashidian, Amir ^g  

^a ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c AJA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

antioxidants; kidney; lipid peroxidation; reactive oxygen species

Indexed keywords

ANTIOXIDANT; CREATININE; GENTAMICIN; GLUTATHIONE; MELATONIN; OXIDOREDUCTASE; SILYMARIN; UREA;

ACUTE KIDNEY FAILURE; ANIMAL; BLOOD; BODY WEIGHT; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; KIDNEY; LIPID PEROXIDATION; MALE; RAT; WISTAR RAT;

ACUTE KIDNEY INJURY; ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CREATININE; GENTAMICINS; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; MALE; MELATONIN; OXIDOREDUCTASES; RATS; RATS, WISTAR; SILYMARIN; UREA;

EID: 84989221417     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: 10.1177/2156587215621672     Document Type: Article

References (54)

1. Shakil S, Khan R, Zarrilli R, Khan AU. Aminoglycosides versus bacteria—a description of the action, resistance mechanism, and nosocomial battleground. J Biomed Sci. 2008;15:5–14.
2. Mwengee W, Butler T, Mgema S. Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. Clin Infect Dis. 2006;42:614–621.
3. Mathew TH. Drug-induced renal disease. Med J Aust. 1992;156:724–728.
4. Yaman I, Balikci E. Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol. 2010;62:183–190.
5. Moreira MA, Nascimento MA, Bozzo TA. Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species. Clin Nutr. 2014;33:296–301.
6. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull. 2009;32:61–67.
7. Dam VP, Scott JL, Ross A, Kinobe RT. Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. Eur J Pharmacol. 2012;685:165–173.
8. Tavafi M, Ahmadvand H. Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats. Tissue Cell. 2011;43:392–397.
9. De la Cruz Rodriguez LC, Araujo CR, Posleman SE, Rey MR. Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine. J Appl Toxicol. 2010;30:343–353.
10. Randjelovic P, Veljkovic S, Stojiljkovic N. Salicylic acid attenuates gentamicin-induced nephrotoxicity in rats. ScientificWorldJournal. 2012;2012:390613.
11. Fouad AA, Albuali WH, Zahran A, Gomaa W. Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats. Environ Toxicol Pharmacol. 2014;38:420–429.
12. Reiter RJ, Calvo JR, Karbownik M, Qi W, Tan DX. Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci. 2000;917:376–386.
13. Bubenik GA, Blask DE, Brown GM. Prospects of the clinical utilization of melatonin. Biol Signals Recept. 1997;7:195–219.
14. Altun A, Ugur-Altun B. Melatonin: therapeutic and clinical utilization. Int J Clin Pract. 2007;61:835–845.
15. Rodriguez C, Mayo JC, Sainz RM. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res. 2004;36:1–9.
16. Allegra M, Reiter R, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin’s interaction with reactive species. J Pineal Res. 2003;34:1–10.
17. Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs. 2001;15:465–489.
18. Pradeep K, Mohan CV, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2007;560:110–116.
19. Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Invest. 2002;22:51–65.
20. Karimi G, Vahabzadeh M, Lari P, Rashedinia M, Moshiri M. “Silymarin”, a promising pharmacological agent for treatment of diseases. Iran J Basic Med Sci. 2011;14:308–317.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358.
22. Kuo CH, Maita K, Sleight SD, Hood JB. Lipid peroxidation: a possible mechanism of cephaloridine-induced nephrotoxicity. Toxicol Appl Pharmacol. 1983;67:78–88.
23. Ali BH. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem Toxicol. 2003;41:1447–1452.
24. Priuska EM, Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol. 1995;50:1749–1752.
25. Yazar E, Elmas M, Altunok V, Sivrikaya A, Oztekin E, Birdane YO. Effects of aminoglycoside antibiotics on renal antioxidants, malondialdehyde levels, and some serum biochemical parameters. Can J Vet Res. 2003;67:239–240.
26. Vijayalekshmy KS, Menon VP, Leelamma S. Role of antibiotics in lipid peroxidation. Indian J Biochem Biophys. 1992;29:371–374.
27. Lee IC, Kim SH, Lee SM. Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats. Arch Toxicol. 2012;86:1527–1536.
28. Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 2003;50:1129–1146.
29. Anisimov VN, Popovich IG, Zabezhinski MA, Anisimov SV, Vesnushkin GM, Vinogradova IA. Melatonin as antioxidant, geroprotector and anticarcinogen. Biochim Biophys Acta. 2006;1757:573–589.
30. Tomás-Zapico C, Coto-Montes A. A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J Pineal Res. 2005;39:99–104.
31. Luchetti F, Canonico B, Betti M. Melatonin signaling and cell protection function. FASEB J. 2010;24:3603–3624.
32. Mun KC, Suh SI. Effect of melatonin on renal function in cyclosporine nephrotoxicity. Transplant Proc. 2000;32:1919–1920.
33. Mahieu S, Contini Mdel C, González M, Millen N. Melatonin reduces oxidative damage induced by aluminium in rat kidney. Toxicol Lett. 2009;190:9–15.
34. Martínez-Alfaro M, Ramírez-García G, Gutiérrez-Granados S. Melatonin attenuates the effects of sub-acute administration of lead on kidneys in rats without altering the lead-induced reduction in nitric oxide. J Trace Elem Med Biol. 2013;27:364–369.
35. Ramirez-Garcia G, Martinez-Alfaro M, Gutierrez-Granados S. Electrochemical assessment of possible melatonin effect on nitric oxide production from kidneys of sub-acute lead treated rats. Electrochim Acta. 2015;166:88–92.
36. Meki AR, Hussein AA. Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp Biochem Physiol C Toxicol Pharmacol. 2001;130:305–313.
37. Kunak ZI, Macit E, Yaren H. Protective effects of melatonin and s-methylisothiourea on mechlorethamine induced nephrotoxicity. J Surg Res. 2012;175:e17–e23.
38. Akakin D, Kiran D, Ozkan N. Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: a morphological and biochemical study. Acta Histochem. 2013;115:827–834.
39. Sener G, Satýroğlu H, Ozer Sehirli A, Kaçmaz A. Melatonin prevents oxidative kidney damage in a rat model of thermal injury. Life Sci. 2002;70:2977–2985.
40. Ha H, Yu MR, Kim KH. Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Radic Biol Med. 1999;26:944–950.
41. Karbownik M, Reiter RJ, Cabrera J, Garcia JJ. Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage. Mutat Res. 2001;474:87–92.
42. Mehrzadi S, Kamrava SK, Dormanesh B. Melatonin synergistically enhances protective effect of atorvastatin against gentamicin-induced nephrotoxicity in rat kidney. Can J Physiol Pharmacol. http://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2015-0277. Published August 28, 2015. Accessed December 1, 2015.
43. Sener G, Sehirli AÖ, Altunbas HZ. Melatonin protects against gentamicin-induced nephrotoxicity in rats. J Pineal Res. 2002;32:231–236.
44. Ozbek E, Turkoz Y, Sahna E, Ozugurlu F, Mizrak B, Ozbek M. Melatonin administration prevents the nephrotoxicity induced by gentamicin. BJU Int. 2000;85:742–746.
45. Ye L, Tao Z, Hua Q. Protective effect of melatonin against gentamicin ototoxicity. J Laryngol Otol. 2009;123:598–602.
46. Shifow A, Kumar K, Naidu M, Ratnakar KS. Melatonin, a pineal hormone with antioxidant property, protects against gentamicin-induced nephrotoxicity in rats. Nephron. 2000;85:167–174.
47. Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns. 2007;33:908–916.
48. Kwon do Y, Jung YS, Kim SJ, Kim YS, Choi DW, Kim YC. Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver. Planta Med. 2013;79:997–1002.
49. Soto C, Recoba R, Barrón H, Alvarez C, Favari L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol. 2003;136:205–212.
50. Podder B, Kim YS, Zerin T, Song HY. Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. Food Chem Toxicol. 2012;50:3206–3214.
51. Hagag A, Abd Elfatah M. Therapeutic value of silymarin as iron chelator in children with beta thalassemia with iron overload. J Leuk. 2014;2:132.
52. Soto C, Pérez J, García V, Uría E, Vadillo M, Raya L. Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus. Phytomedicine. 2010;17:1090–1094.
53. Varzi HN, Esmailzadeh S, Morovvati H, Avizeh R, Shahriari A, Givi ME. Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. J Vet Pharmacol Ther. 2007;30:477–481.
54. Karimi G, Ramezani M, Tahoonian Z. Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evid Based Complement Alternat Med. 2005;2:383–386.