Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats

Environmental Toxicology and Pharmacology

Volumn 38, Issue 2, 2014, Pages 420-429

  Fouad, Amr A ^a,c   Albuali, Waleed H ^a   Zahran, Ahmed ^a,d   Gomaa, Wafaey ^b,c  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

^b Aziz University   (Saudi Arabia)

^c Minia University   (Egypt)

^d MENOUFIA UNIVERSITY   (Egypt)

Author keywords

Acute kidney injury; Gentamicin; Naringenin; Rats

Indexed keywords

CASPASE 9; CREATININE; GENTAMICIN; GLUTATHIONE PEROXIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; KIDNEY INJURY MOLECULE 1; MALONALDEHYDE; NARINGENIN; NITRIC OXIDE; SURVIVIN; VASCULOTROPIN; ANTIINFECTIVE AGENT; FLAVANONE DERIVATIVE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY PARENCHYMA; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; TREATMENT DURATION; TREATMENT OUTCOME; ANIMAL; CHEMICALLY INDUCED; DRUG ANTAGONISM; DRUG EFFECTS; GENE EXPRESSION REGULATION; KIDNEY; KIDNEY FUNCTION TEST; OXIDATIVE STRESS; PATHOLOGY; RENAL INSUFFICIENCY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG ANTAGONISM; FLAVANONES; GENE EXPRESSION REGULATION; GENTAMICINS; KIDNEY; KIDNEY FUNCTION TESTS; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY;

EID: 84908030532     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.07.015     Document Type: Article

References (49)

1. Al-Rejaie S.S., Abuohashish H.M., Al-Enazi M.M., Al-Assaf A.H., Parmar M.Y., Ahmed M.M. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World J. Gastroenterol. 2013, 19:5633-5644.
2. Anandan R., Subramanian P. Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats. Redox Rep. 2012, 17:219-226.
3. Annadurai T., Thomas P.A., Geraldine P. Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus. Free Radic. Res. 2013, 47:793-803.
4. Arul D., Subramanian P. Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. Biochem. Biophys. Res. Commun. 2013, 434:203-209.
5. Aygün F.O., Akçam F.Z., Kaya O., Ceyhan B.M., Sütçü R. Caffeic acid phenethyl ester modulates gentamicin-induced oxidative nephrotoxicity in kidney of rats. Biol. Trace Elem. Res. 2012, 145:211-216.
6. Badarya O.A., Abdel-Maksoud S., Ahmed W.A., Owieda G.H. Naringenin attenuates cisplatin nephrotoxicity in rats. Life Sci. 2005, 76:2125-2135.
7. Barza M., Ioannidis J.P., Cappelleri J.C., Lau J. Single or multiple daily doses of aminoglycosides: a meta-analysis. Br. Med. J. 1996, 312:338-345.
8. Bonventre J.V. Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol. Dial. Transplant. 2009, 24:3265-3268.
9. Chen Y.C., Chen C.H., Hsu Y.H., Chen T.H., Sue Y.M., Cheng C.Y., Chen T.W. Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway. Eur. J. Pharmacol. 2011, 658:213-218.
10. Cheung C.H., Huang C.C., Tsai F.Y., Lee J.Y., Cheng S.M., Chang Y.C., Huang Y.C., Chen S.H., Chang J.Y. Survivin - biology and potential as a therapeutic target in oncology. Onco Targets Ther. 2013, 6:1453-1462.
11. Dam V.P., Scott J.L., Ross A., Kinobe R.T. Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. Eur. J. Pharmacol. 2012, 685:165-173.
12. El-Remessy A.B., Behzadian M.A., Abou-Mohamed G., Franklin T., Caldwell R.W., Caldwell R.B. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am. J. Pathol. 2004, 162:1995-2004.
13. Esmaeili M.A., Alilou M. Naringenin attenuates CCl4-induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats. Clin. Exp. Pharmacol. Physiol. 2014, 41:416-422.
14. Feliers D., Gorin Y., Ghosh-Choudhury G., About H.E., Kasinath B.S. Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species. Am. J. Physiol. Renal Physiol. 2006, 290:F927-F936.
15. Feyissa T., Asres K., Engidawork E. Renoprotective effects of the crude extract and solvent fractions of the leaves of Euclea divinorum Hierns against gentamicin-induced nephrotoxicity in rats. J. Ethnopharmacol. 2013, 145:758-766.
16. Gnanasoundari M., Pari L. Impact of naringenin on oxytetracycline-mediated oxidative damage in kidney of rats. Ren. Fail. 2006, 28:599-605.
17. Hermenean A., Ardelean A., Stan M., Herman H., Mihali C.V., Costache M., Dinischiotu A. Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney. Chemico-Biol. Inter. 2013, 205:138-147.
18. Hoffmann D., Fuchs T.C., Henzler T., Matheis K.A., Herget T., Dekant W., Hewitt P., Mally A. Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity. Toxicology 2010, 277:49-58.
19. Hossain M.M., Banik N.L., Ray S.K. Survivin knockdown increased anti-cancer effects of (-)-epigallocatechin-3-gallate in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Exp. Cell Res. 2012, 318:1597-1610.
20. Ichimura T., Brooks C.R., Bonventre J.V. Kim-1/Tim-1 and immune cells: shifting sands. Kidney Int. 2012, 81:809-811.
21. Institute for Laboratory Animal Research Guide for the Care and Use of Laboratory Animals 2011, National Academies Press, Washington, DC. 8th ed.
22. Jayaraman J., Jesudoss V.A., Menon V.P., Namasivayam N. Anti-inflammatory role of naringenin in rats with ethanol induced liver injury. Toxicol. Mech. Methods 2012, 22:568-576.
23. Kalayarasan S., Prabhu P.N., Sriram N., Manikandan R., Arumugam M., Sudhandiran G. Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats. Eur. J. Pharmacol. 2009, 606:162-171.
24. Kwon O., Molitoris B.A., Pescovitz M., Kelly K.J. Urinary actin, interleukin-6, and interleukin-8 may predict sustained art after ischemic injury in renal allografts. Am. J. Kidney Dis. 2003, 41:1074-1087.
25. Lee I.C., Kim S.H., Lee S.M., Baek H.S., Moon C., Kim S.H., Park S.C., Kim H.C., Kim J.C. Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats. Arch. Toxicol. 2012, 86:1527-1536.
26. Liangos O., Kolyada A., Tighiouart H., Perianayagam M.C., Wald R., Jaber B.L. Interleukin-8 and acute kidney injury following cardiopulmonary bypass: a prospective cohort study. Nephron Clin. Pract. 2009, 113:c148-c154.
27. Lim R., Barker G., Wall C.A., Lappas M. Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium. Mol. Hum. Reprod. 2013, 19:451-462.
28. Manikandan R., Beulaja M., Thiagarajan R., Priyadarsini A., Saravanan R., Arumugam M. Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats. Eur. J. Pharmacol. 2011, 670:578-585.
29. Martensson J., Martling C.R., Bell M. Novel biomarkers of acute kidney injury and failure: clinical applicability. Br. J. Anaesth. 2012, 109:843-850.
30. Martinez-Salgado C., Lopez-Hernandez F.J., Lopez-Novoa J.M. Glomerular nephrotoxicity of aminoglycosides. Toxicol. Appl. Pharmacol. 2007, 223:86-98.
31. Mattew T.H. Drug-induced renal disease. Med. J. Aust. 1992, 156:724-728.
32. Mershiba S.D., Dassprakash M.V., Saraswathy S.D. Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Mol. Biol. Rep. 2013, 40:3681-3691.
33. Mohamed H.E., El-Swefy S.E., Mohamed R.H., Ghanim A.M. Effect of erythropoietin therapy on the progression of cisplatin induced renal injury in rats. Exp. Toxicol. Pathol. 2013, 65:197-203.
34. Negrette-Guzmán M., Huerta-Yepez S., Medina-Campos O.N., Zatarain-Barrón Z.L., Hernández-Pando R., Torres I., Tapia E., Pedraza-Chaverri J. Sulforaphane attenuates gentamicin-induced nephrotoxicity: role of mitochondrial protection. Evid. Based Complement. Alternat. Med. 2013, 2013:135314.
35. Ortiz-Andrade R.R., Sanchez-Salgado J.C., Navarrete-Vazquez G., Webster S.P., Binnie M., Garcia-Jimenez S., Leon-Rivera I., Cigarroa-Vazquez P., Villalobos-Molina R., Estrada-Soto S. Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diabetes Obes. Metab. 2008, 10:1097-1104.
36. Otunctemur A., Ozbek E., Cekmen M., Cakir S.S., Dursun M., Polat E.C., Somay A., Ozbay N. Protective effect of montelukast which is cysteinyl-leukotriene receptor antagonist on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Ren. Fail. 2013, 35:403-410.
37. Parlakpinar H., Tasdemir S., Polat A., Bay-Karabulut A., Vardi N., Ucar M., Acet A. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology 2005, 207:169-177.
38. Patel Manali B., Deshpande S., Shah G. Evaluation of efficacy of vitamin E and N-acetyl cysteine in gentamicin-induced nephrotoxicity in rats. Ren. Fail. 2011, 33:341-347.
39. Priyamvada S., Priyadarshini M., Arivarasu N.A., Farooq N., Khan S., Khan S.A. Studies on the protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Prostaglandins Leukot. Essent. Fatty Acids 2008, 78:369-381.
40. Ramesh G., Reeves W.B. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am. J. Physiol. Renal Physiol. 2005, 289:F166-F174.
41. Ramprasath T., Senthamizharasi M., Vasudevan V., Sasikumar S., Yuvaraj S., Selvam G.S. Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells. J. Physiol. Biochem. 2014, 70:407-415.
42. Rasmussen O.F. Controls. Immunohistochemical Staining Methods 2009, 127. Dako North America, Carpinteria, CA. G.L. Kumar, L. Rudbeck (Eds.).
43. Renugadevi J., Prabu S.M. Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology 2009, 256:128-134.
44. Ryan B.M., O'Donovan N., Duffy M.J. Survivin: a new target for anti-cancer therapy. Cancer Treat. Rev. 2009, 35:553-562.
45. Sanchez-Gonzalez P.D., Lopez-Hernandez F.J., Perez-Barriocanal F., Morales A.I., Lopez-Novoa J.M. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol. Dial. Transplant. 2011, 26:3484-3495.
46. Selby N.M., Shaw S.M., Woodier N., Fluck R.J., Kohle N.V. Gentamicin-associated acute kidney injury. Q. J. Med. 2009, 102:873-880.
47. Shifow A.A., Kumar K.V., Naidu M.U.R., Ratnakar K.S. Melatonin a pineal hormone with antioxidant property protects against gentamicin-induced nephrotoxicity in rats. Nephron 2000, 85:167-174.
48. Sirota J.C., Walcher A., Faubel S., Jani A., McFann K., Devarajan P., Davis C.L., Edelstein C.L. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013, 14:17.
49. Stojiljkovic N., Stoiljkovic M., Randjelovic P., Veljkovic S., Mihailovic D. Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats. Exp. Toxicol. Pathol. 2012, 64:69-74.