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Volumn 10, Issue , 2016, Pages 3029-3042

The spice for joint inflammation: Anti-inflammatory role of curcumin in treating osteoarthritis

Author keywords

Cartilage; Chondrocyte; Curcuma; Inflammation; Joint; Pain

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CURCUMA EXTRACT; CURCUMIN; CURCUMINOID DERIVATIVE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; PLACEBO; PLANT EXTRACT; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEOGLYCAN; STROMELYSIN; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84989191907     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S117432     Document Type: Review
Times cited : (144)

References (69)
  • 1
    • 84938216409 scopus 로고    scopus 로고
    • Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use
    • Kraus VB, Blanco FJ, Englund M, Karsdal MA, Lohmander LS. Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage. 2015;23(8):1233-1241.
    • (2015) Osteoarthritis Cartilage , vol.23 , Issue.8 , pp. 1233-1241
    • Kraus, V.B.1    Blanco, F.J.2    Englund, M.3    Karsdal, M.A.4    Lohmander, L.S.5
  • 2
    • 0022465236 scopus 로고
    • Development of criteria for the classi-fication and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria committee of the American Rheumatism Association
    • Altman R, Asch E, Bloch D, et al. Development of criteria for the classi-fication and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039-1049.
    • (1986) Arthritis Rheum , vol.29 , Issue.8 , pp. 1039-1049
    • Altman, R.1    Asch, E.2    Bloch, D.3
  • 3
    • 84989211500 scopus 로고    scopus 로고
    • Osteoarthritis (OA); 2015. Available from, Accessed June 18
    • Centers for Disease Control and Prevention. Osteoarthritis (OA); 2015. Available from: http://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Accessed June 18, 2016.
    • (2016)
  • 4
    • 84902254577 scopus 로고    scopus 로고
    • The global burden of hip and knee osteoarthritis: Estimates from the global burden of disease 2010 study
    • Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323-1330.
    • (2014) Ann Rheum Dis , vol.73 , Issue.7 , pp. 1323-1330
    • Cross, M.1    Smith, E.2    Hoy, D.3
  • 5
    • 33751005849 scopus 로고    scopus 로고
    • Prevalence of knee osteoarthritis in the United States: Arthritis data from the Third National Health and Nutrition Examination Survey 1991-1994
    • Dillon CF, Rasch EK, Gu Q, Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-1994. J Rheumatol. 2006;33(11):2271-2279.
    • (2006) J Rheumatol , vol.33 , Issue.11 , pp. 2271-2279
    • Dillon, C.F.1    Rasch, E.K.2    Gu, Q.3    Hirsch, R.4
  • 6
    • 84881264653 scopus 로고    scopus 로고
    • All cause and disease specific mortality in patients with knee or hip osteoarthritis: Population based cohort study
    • Nuesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Juni P. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ. 2011;342:d1165.
    • (2011) BMJ , vol.342
    • Nuesch, E.1    Dieppe, P.2    Reichenbach, S.3    Williams, S.4    Iff, S.5    Juni, P.6
  • 7
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163-2196.
    • (2012) Lancet , vol.380 , Issue.9859 , pp. 2163-2196
    • Vos, T.1    Flaxman, A.D.2    Naghavi, M.3
  • 8
    • 84887239516 scopus 로고    scopus 로고
    • The direct and indirect costs to society of treatment for end-stage knee osteoarthritis
    • Ruiz D Jr, Koenig L, Dall TM, et al. The direct and indirect costs to society of treatment for end-stage knee osteoarthritis. J Bone Joint Surg Am. 2013;95(16):1473-1480.
    • (2013) J Bone Joint Surg Am , vol.95 , Issue.16 , pp. 1473-1480
    • Ruiz Jr, D.1    Koenig, L.2    Dall, T.M.3
  • 10
    • 84866326182 scopus 로고    scopus 로고
    • Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4
    • Sohn DH, Sokolove J, Sharpe O, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012;14(1):R7.
    • (2012) Arthritis Res Ther , vol.14 , Issue.1 , pp. R7
    • Sohn, D.H.1    Sokolove, J.2    Sharpe, O.3
  • 11
    • 84885911247 scopus 로고    scopus 로고
    • Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations
    • Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculosk-elet Dis. 2013;5(2):77-94.
    • (2013) Ther Adv Musculosk-elet Dis , vol.5 , Issue.2 , pp. 77-94
    • Sokolove, J.1    Lepus, C.M.2
  • 12
    • 79952451523 scopus 로고    scopus 로고
    • The role of mitochondria in osteoarthritis
    • Blanco FJ, Rego I, Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol. 2011;7(3):161-169.
    • (2011) Nat Rev Rheumatol , vol.7 , Issue.3 , pp. 161-169
    • Blanco, F.J.1    Rego, I.2    Ruiz-Romero, C.3
  • 13
    • 84859773681 scopus 로고    scopus 로고
    • American College of Rheu-matology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
    • Hochberg MC, Altman RD, April KT, et al. American College of Rheu-matology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012;64(4):465-474.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.4 , pp. 465-474
    • Hochberg, M.C.1    Altman, R.D.2    April, K.T.3
  • 14
    • 84902549355 scopus 로고    scopus 로고
    • A system-atic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative
    • Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A system-atic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014;43(6):701-712.
    • (2014) Semin Arthritis Rheum , vol.43 , Issue.6 , pp. 701-712
    • Nelson, A.E.1    Allen, K.D.2    Golightly, Y.M.3    Goode, A.P.4    Jordan, J.M.5
  • 15
    • 38949130488 scopus 로고    scopus 로고
    • OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines
    • Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137-162.
    • (2008) Osteoarthritis Cartilage , vol.16 , Issue.2 , pp. 137-162
    • Zhang, W.1    Moskowitz, R.W.2    Nuki, G.3
  • 16
    • 77950021805 scopus 로고    scopus 로고
    • OARSI recommendations for the management of hip and knee osteoarthritis: Part III: Changes in evidence following systematic cumulative update of research pub-lished through January 2009
    • Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research pub-lished through January 2009. Osteoarthritis Cartilage. 2010;18(4):476-499.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.4 , pp. 476-499
    • Zhang, W.1    Nuki, G.2    Moskowitz, R.W.3
  • 17
    • 34548548907 scopus 로고    scopus 로고
    • OARSI recommendations for the management of hip and knee osteoarthritis, part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence
    • Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007;15(9):981-1000.
    • (2007) Osteoarthritis Cartilage , vol.15 , Issue.9 , pp. 981-1000
    • Zhang, W.1    Moskowitz, R.W.2    Nuki, G.3
  • 18
    • 84878800652 scopus 로고    scopus 로고
    • Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies
    • Varas-Lorenzo C, Riera-Guardia N, Calingaert B, et al. Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 2013;22(6):559-570.
    • (2013) Pharmacoepidemiol Drug Saf , vol.22 , Issue.6 , pp. 559-570
    • Varas-Lorenzo, C.1    Riera-Guardia, N.2    Calingaert, B.3
  • 19
    • 84944883448 scopus 로고    scopus 로고
    • A randomized, controlled trial of total knee replacement
    • Skou ST, Roos EM, Laursen MB, et al. A randomized, controlled trial of total knee replacement. N Engl J Med. 2015;373(17):1597-1606.
    • (2015) N Engl J Med , vol.373 , Issue.17 , pp. 1597-1606
    • Skou, S.T.1    Roos, E.M.2    Laursen, M.B.3
  • 20
    • 84921535683 scopus 로고    scopus 로고
    • Curcumin, a component of golden spice: From bedside to bench and back
    • Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014;32(6):1053-1064.
    • (2014) Biotechnol Adv , vol.32 , Issue.6 , pp. 1053-1064
    • Prasad, S.1    Gupta, S.C.2    Tyagi, A.K.3    Aggarwal, B.B.4
  • 21
    • 45949103317 scopus 로고    scopus 로고
    • Role of curcumin in health and disease
    • Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114(2):127-149.
    • (2008) Arch Physiol Biochem , vol.114 , Issue.2 , pp. 127-149
    • Pari, L.1    Tewas, D.2    Eckel, J.3
  • 22
    • 80051484401 scopus 로고    scopus 로고
    • Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: Role of the phosphatidylinositol 3-kinase/Akt pathway
    • Buhrmann C, Mobasheri A, Busch F, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011;286(32):28556-28566.
    • (2011) J Biol Chem , vol.286 , Issue.32 , pp. 28556-28566
    • Buhrmann, C.1    Mobasheri, A.2    Busch, F.3
  • 23
    • 84953359403 scopus 로고    scopus 로고
    • Strategy to suppress oxidative damage-induced neurotoxicity in PC12 cells by curcumin: The role of ROS-mediated DNA damage and the MAPK and AKT pathways
    • Fu XY, Yang MF, Cao MZ, et al. Strategy to suppress oxidative damage-induced neurotoxicity in PC12 cells by curcumin: the role of ROS-mediated DNA damage and the MAPK and AKT pathways. Mol Neurobiol. 2016;53(1):369-378.
    • (2016) Mol Neurobiol , vol.53 , Issue.1 , pp. 369-378
    • Fu, X.Y.1    Yang, M.F.2    Cao, M.Z.3
  • 24
    • 84875501916 scopus 로고    scopus 로고
    • Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway
    • Wu J, Li Q, Wang X, et al. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS One. 2013;8(3):e59843.
    • (2013) PLoS One , vol.8 , Issue.3
    • Wu, J.1    Li, Q.2    Wang, X.3
  • 25
    • 84956881839 scopus 로고    scopus 로고
    • Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway
    • Cui Q, Li X, Zhu H. Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway. Mol Med Rep. 2016;13(2):1381-1388.
    • (2016) Mol Med Rep , vol.13 , Issue.2 , pp. 1381-1388
    • Cui, Q.1    Li, X.2    Zhu, H.3
  • 26
    • 45849115079 scopus 로고    scopus 로고
    • Antioxidant and radical scavenging properties of cur-cumin
    • Ak T, Gulcin I. Antioxidant and radical scavenging properties of cur-cumin. Chem Biol Interact. 2008;174(1):27-37.
    • (2008) Chem Biol Interact , vol.174 , Issue.1 , pp. 27-37
    • Ak, T.1    Gulcin, I.2
  • 27
    • 84872467113 scopus 로고    scopus 로고
    • A randomized controlled trialon the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications
    • Panahi Y, Sahebkar A, Parvin S, Saadat A. A randomized controlled trialon the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem. 2012;49(Pt 6):580-588.
    • (2012) Ann Clin Biochem , vol.49 , pp. 580-588
    • Panahi, Y.1    Sahebkar, A.2    Parvin, S.3    Saadat, A.4
  • 28
    • 84908503753 scopus 로고    scopus 로고
    • Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflam-mation and improves quality of life in patients with solid tumors: A randomized double-blind placebo-controlled trial
    • Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflam-mation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(10):1461-1467.
    • (2014) Phytother Res , vol.28 , Issue.10 , pp. 1461-1467
    • Panahi, Y.1    Saadat, A.2    Beiraghdar, F.3    Sahebkar, A.4
  • 29
    • 84925512235 scopus 로고    scopus 로고
    • Curcumin attenuates CFA induced thermal hype-ralgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6
    • Singh AK, Vinayak M. Curcumin attenuates CFA induced thermal hype-ralgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6. Neurochem Res. 2015;40(3):463-472.
    • (2015) Neurochem Res , vol.40 , Issue.3 , pp. 463-472
    • Singh, A.K.1    Vinayak, M.2
  • 30
    • 84907813715 scopus 로고    scopus 로고
    • Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: The prevention of curcumin
    • Xu D, Hu L, Su C, et al. Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicol Appl Pharmacol. 2014;280(2):305-313.
    • (2014) Toxicol Appl Pharmacol , vol.280 , Issue.2 , pp. 305-313
    • Xu, D.1    Hu, L.2    Su, C.3
  • 31
    • 77950516262 scopus 로고    scopus 로고
    • Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model
    • Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol. 2010;10(5):605-610.
    • (2010) Int Immunopharmacol , vol.10 , Issue.5 , pp. 605-610
    • Moon, D.O.1    Kim, M.O.2    Choi, Y.H.3    Park, Y.M.4    Kim, G.Y.5
  • 33
    • 84912031918 scopus 로고    scopus 로고
    • Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study
    • Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014;19(6):933-939.
    • (2014) J Orthop Sci , vol.19 , Issue.6 , pp. 933-939
    • Nakagawa, Y.1    Mukai, S.2    Yamada, S.3
  • 34
    • 84947021278 scopus 로고    scopus 로고
    • Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a random-ized controlled trial
    • Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a random-ized controlled trial. J Diet Suppl. 2016;13(2):209-220.
    • (2016) J Diet Suppl , vol.13 , Issue.2 , pp. 209-220
    • Panahi, Y.1    Alishiri, G.H.2    Parvin, S.3    Sahebkar, A.4
  • 35
    • 84908220474 scopus 로고    scopus 로고
    • Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial
    • Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(11):1625-1631.
    • (2014) Phytother Res , vol.28 , Issue.11 , pp. 1625-1631
    • Panahi, Y.1    Rahimnia, A.R.2    Sharafi, M.3    Alishiri, G.4    Saburi, A.5    Sahebkar, A.6
  • 36
    • 84943587131 scopus 로고    scopus 로고
    • Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial
    • Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized double-blind placebo-controlled trial. Drug Res (Stuttg). 2015;65(10):521-525.
    • (2015) Drug Res (Stuttg) , vol.65 , Issue.10 , pp. 521-525
    • Rahimnia, A.R.1    Panahi, Y.2    Alishiri, G.3    Sharafi, M.4    Sahebkar, A.5
  • 37
    • 84897826213 scopus 로고    scopus 로고
    • Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study
    • Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458.
    • (2014) Clin Interv Aging , vol.9 , pp. 451-458
    • Kuptniratsaikul, V.1    Dajpratham, P.2    Taechaarpornkul, W.3
  • 39
    • 84885110104 scopus 로고    scopus 로고
    • Clinical evaluation of a formulation containing Cur-cuma longa and Boswellia serrata extracts in the management of knee osteoarthritis
    • Kizhakkedath R. Clinical evaluation of a formulation containing Cur-cuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep. 2013;8(5):1542-1548.
    • (2013) Mol Med Rep , vol.8 , Issue.5 , pp. 1542-1548
    • Kizhakkedath, R.1
  • 40
    • 84871911672 scopus 로고    scopus 로고
    • Marsetyawan Ability of cur-cuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes of patients with osteoarthritis
    • Kertia N, Asdie AH, Rochmah W, Marsetyawan. Ability of cur-cuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes of patients with osteoarthritis. Acta Med Indones. 2012;44(2):105-113.
    • (2012) Acta Med Indones , vol.44 , Issue.2 , pp. 105-113
    • Kertia, N.1    Asdie, A.H.2    Rochmah, W.3
  • 41
    • 79952253826 scopus 로고    scopus 로고
    • Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
    • Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15(4):337-344.
    • (2010) Altern Med Rev , vol.15 , Issue.4 , pp. 337-344
    • Belcaro, G.1    Cesarone, M.R.2    Dugall, M.3
  • 42
    • 79952201693 scopus 로고    scopus 로고
    • Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis
    • Belcaro G, Cesarone MR, Dugall M, et al. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55-62.
    • (2010) Panminerva Med , vol.52 , pp. 55-62
    • Belcaro, G.1    Cesarone, M.R.2    Dugall, M.3
  • 43
    • 84938870912 scopus 로고    scopus 로고
    • Meriva(R)+Glucosamine versus Chondroitin + Glucosamine in patients with knee osteoarthritis: An obser-vational study
    • Belcaro G, Dugall M, Luzzi R, et al. Meriva(R)+Glucosamine versus Chondroitin + Glucosamine in patients with knee osteoarthritis: an obser-vational study. Eur Rev Med Pharmacol Sci. 2014;18(24):3959-3963.
    • (2014) Eur Rev Med Pharmacol Sci , vol.18 , Issue.24 , pp. 3959-3963
    • Belcaro, G.1    Dugall, M.2    Luzzi, R.3
  • 44
    • 84877253326 scopus 로고    scopus 로고
    • Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial
    • Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013;21(2):129-136.
    • (2013) Inflammopharmacology , vol.21 , Issue.2 , pp. 129-136
    • Madhu, K.1    Chanda, K.2    Saji, M.J.3
  • 45
    • 84928883675 scopus 로고    scopus 로고
    • A new curcuma extract (flexofytol(R)) in osteoarthritis: Results from a belgian real-life experience
    • Appelboom T, Maes N, Albert A. A new curcuma extract (flexofytol(R)) in osteoarthritis: results from a belgian real-life experience. Open Rheumatol J. 2014;8:77-81.
    • (2014) Open Rheumatol J , vol.8 , pp. 77-81
    • Appelboom, T.1    Maes, N.2    Albert, A.3
  • 46
    • 84901508680 scopus 로고    scopus 로고
    • Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treat-ment with highly bioavailable curcumin during an exploratory clinical trial
    • Henrotin Y, Gharbi M, Dierckxsens Y, et al. Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treat-ment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complement Altern Med. 2014;14:159.
    • (2014) BMC Complement Altern Med , vol.14 , pp. 159
    • Henrotin, Y.1    Gharbi, M.2    Dierckxsens, Y.3
  • 47
    • 0025766095 scopus 로고
    • Treat-ment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study
    • Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treat-ment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33(1-2):91-95.
    • (1991) J Ethnopharmacol , vol.33 , Issue.1-2 , pp. 91-95
    • Kulkarni, R.R.1    Patki, P.S.2    Jog, V.P.3    Gandage, S.G.4    Patwardhan, B.5
  • 49
    • 84961217782 scopus 로고    scopus 로고
    • Oral bioavailability of curcumin: Problems and advancements
    • Liu W, Zhai Y, Heng X, et al. Oral bioavailability of curcumin: problems and advancements. J Drug Target. 2016;24(8):694-702.
    • (2016) J Drug Target , vol.24 , Issue.8 , pp. 694-702
    • Liu, W.1    Zhai, Y.2    Heng, X.3
  • 51
    • 84929746463 scopus 로고    scopus 로고
    • Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study
    • Sunagawa Y, Hirano S, Katanasaka Y, et al. Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study. J Nutr Sci Vitaminol (Tokyo). 2015;61(1):37-44.
    • (2015) J Nutr Sci Vitaminol (Tokyo) , vol.61 , Issue.1 , pp. 37-44
    • Sunagawa, Y.1    Hirano, S.2    Katanasaka, Y.3
  • 52
    • 84888594853 scopus 로고    scopus 로고
    • Drinkable preparation of Theracurmin exhibits high absorption efficiency - A single-dose, double-blind, 4-way crossover study
    • Morimoto T, Sunagawa Y, Katanasaka Y, et al. Drinkable preparation of Theracurmin exhibits high absorption efficiency - a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull. 2013;36(11):1708-1714.
    • (2013) Biol Pharm Bull , vol.36 , Issue.11 , pp. 1708-1714
    • Morimoto, T.1    Sunagawa, Y.2    Katanasaka, Y.3
  • 53
    • 84878654571 scopus 로고    scopus 로고
    • A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Thera-curmin) in cancer patients
    • Kanai M, Otsuka Y, Otsuka K, et al. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Thera-curmin) in cancer patients. Cancer Chemother Pharmacol. 2013;71(6):1521-1530.
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.6 , pp. 1521-1530
    • Kanai, M.1    Otsuka, Y.2    Otsuka, K.3
  • 54
    • 0027249976 scopus 로고
    • Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intes-tine of rat and guinea pig in vitro by piperine
    • Reen RK, Jamwal DS, Taneja SC, et al. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intes-tine of rat and guinea pig in vitro by piperine. Biochem Pharmacol. 1993;46(2):229-238.
    • (1993) Biochem Pharmacol , vol.46 , Issue.2 , pp. 229-238
    • Reen, R.K.1    Jamwal, D.S.2    Taneja, S.C.3
  • 55
    • 0031860081 scopus 로고    scopus 로고
    • Influ-ence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influ-ence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356.
    • (1998) Planta Med , vol.64 , Issue.4 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.6
  • 56
    • 84925711177 scopus 로고    scopus 로고
    • Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator’s synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer
    • Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y. Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator’s synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. PLoS One. 2015;10(3):e0121654.
    • (2015) PLoS One , vol.10 , Issue.3
    • Comblain, F.1    Sanchez, C.2    Lesponne, I.3    Balligand, M.4    Serisier, S.5    Henrotin, Y.6
  • 57
    • 76449099412 scopus 로고    scopus 로고
    • Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis
    • Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. 2009;11(6):R165.
    • (2009) Arthritis Res Ther , vol.11 , Issue.6 , pp. R165
    • Csaki, C.1    Mobasheri, A.2    Shakibaei, M.3
  • 58
    • 15044364010 scopus 로고    scopus 로고
    • Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes
    • Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci. 2004;1030:578-586.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 578-586
    • Schulze-Tanzil, G.1    Mobasheri, A.2    Sendzik, J.3    John, T.4    Shakibaei, M.5
  • 59
    • 33947373996 scopus 로고    scopus 로고
    • Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis
    • Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007;73(9):1434-1445.
    • (2007) Biochem Pharmacol , vol.73 , Issue.9 , pp. 1434-1445
    • Shakibaei, M.1    John, T.2    Schulze-Tanzil, G.3    Lehmann, I.4    Mobasheri, A.5
  • 60
    • 79956353187 scopus 로고    scopus 로고
    • Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro
    • Shakibaei M, Mobasheri A, Buhrmann C. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr. 2011;6(2):171-179.
    • (2011) Genes Nutr , vol.6 , Issue.2 , pp. 171-179
    • Shakibaei, M.1    Mobasheri, A.2    Buhrmann, C.3
  • 61
    • 28344447838 scopus 로고    scopus 로고
    • Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: An immunomorphological study
    • Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat. 2005;187(5-6):487-497.
    • (2005) Ann Anat , vol.187 , Issue.5-6 , pp. 487-497
    • Shakibaei, M.1    Schulze-Tanzil, G.2    John, T.3    Mobasheri, A.4
  • 62
    • 77954082316 scopus 로고    scopus 로고
    • Curcumin medi-ated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
    • Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin medi-ated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther. 2010;12(4):R127.
    • (2010) Arthritis Res Ther , vol.12 , Issue.4 , pp. R127
    • Buhrmann, C.1    Mobasheri, A.2    Matis, U.3    Shakibaei, M.4
  • 63
    • 84898987744 scopus 로고    scopus 로고
    • Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1beta-treated articular cartilage
    • Clutterbuck AL, Allaway D, Harris P, Mobasheri A. Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1beta-treated articular cartilage. F1000Res. 2013;2:147.
    • (2013) F1000Res , vol.2 , pp. 147
    • Clutterbuck, A.L.1    Allaway, D.2    Harris, P.3    Mobasheri, A.4
  • 64
    • 84869861761 scopus 로고    scopus 로고
    • Inhibition effect of curcumin on TNF-alpha and MMP-13 expression induced by advanced glycation end products in chondrocytes
    • Yang Q, Wu S, Mao X, Wang W, Tai H. Inhibition effect of curcumin on TNF-alpha and MMP-13 expression induced by advanced glycation end products in chondrocytes. Pharmacology. 2013;91(1-2):77-85.
    • (2013) Pharmacology , vol.91 , Issue.1-2 , pp. 77-85
    • Yang, Q.1    Wu, S.2    Mao, X.3    Wang, W.4    Tai, H.5
  • 65
    • 51149086612 scopus 로고    scopus 로고
    • Comparison between chondropro-tective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes
    • Toegel S, Wu SQ, Piana C, et al. Comparison between chondropro-tective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Osteoarthritis Cartilage. 2008;16(10):1205-1212.
    • (2008) Osteoarthritis Cartilage , vol.16 , Issue.10 , pp. 1205-1212
    • Toegel, S.1    Wu, S.Q.2    Piana, C.3
  • 66
    • 31544438079 scopus 로고    scopus 로고
    • Curcumin synergistically poten-tiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells
    • Lev-Ari S, Strier L, Kazanov D, et al. Curcumin synergistically poten-tiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford). 2006;45(2):171-177.
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.2 , pp. 171-177
    • Lev-Ari, S.1    Strier, L.2    Kazanov, D.3
  • 67
    • 84954554001 scopus 로고    scopus 로고
    • Randomized con-trolled studies on the efficacy of antiarthritic agents in inhibiting carti-lage degeneration and pain associated with progression of osteoarthritis in the rat
    • TenBroek EM, Yunker L, Nies MF, Bendele AM. Randomized con-trolled studies on the efficacy of antiarthritic agents in inhibiting carti-lage degeneration and pain associated with progression of osteoarthritis in the rat. Arthritis Res Ther. 2016;18:24.
    • (2016) Arthritis Res Ther , vol.18 , pp. 24
    • TenBroek, E.M.1    Yunker, L.2    Nies, M.F.3    Bendele, A.M.4
  • 68
  • 69
    • 84928338081 scopus 로고    scopus 로고
    • The contribution of NF-kappaB signalling to immune regulation and tolerance
    • van Delft MA, Huitema LF, Tas SW. The contribution of NF-kappaB signalling to immune regulation and tolerance. Eur J Clin Invest. 2015;45(5):529-539.
    • (2015) Eur J Clin Invest , vol.45 , Issue.5 , pp. 529-539
    • van Delft, M.A.1    Huitema, L.F.2    Tas, S.W.3


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