DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function

Cell Death and Disease

Volumn 6, Issue 3, 2015, Pages

  Schlegel, C R ^a   Georgiou, M L ^a   Misterek, M B ^a,b   Stocker S ^a,c   Chater, E R ^a   Munro, C E ^a   Pardo, O E ^a   Seckl, M J ^a   Costa Pereira, A P ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SERINE THREONINE KINASE; RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UNCLASSIFIED DRUG; DEATH ASSOCIATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE;

A549 CELL LINE; ARTICLE; CANCER CELL LINE; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE OVEREXPRESSION; LUNG CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; U2OS CELL LINE; UPREGULATION; FLOW CYTOMETRY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; DEATH-ASSOCIATED PROTEIN KINASES; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE;

EID: 84988896112     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.31     Document Type: Article

References (39)

1. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A. Identification of a novel serine/ threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferoninduced cell death. Genes Dev 1995; 9: 15-30.
2. Shang T, Joseph J, Hillard CJ, Kalyanaraman B. Death-Associated protein kinase as a sensor of mitochondrial membrane potential: Role of lysosome in mitochondrial toxin-induced cell death. J Biol Chem 2005; 280: 34644-34653.
3. Mor I, Carlessi R, Ast T, Feinstein E, Kimchi A. Death-Associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase. Oncogene 2012; 31: 683-693.
4. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA et al. Deathassociated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene 1999; 18: 3471-3480.
5. Cohen O, Feinstein E, Kimchi A. DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletalassociated protein kinase, with cell death-inducing functions that depend on its catalytic activity. The EMBO J 1997; 16: 998-1008.
6. Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol 2002; 157: 455-468.
7. Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A. Death-Associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol 2000; 20: 1044-1054.
8. Lin Y, Stevens C, Hupp T. Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. J Biol Chem 2007; 282: 16792-16802.
9. Schlegel CR, Fonseca AV, Stocker S, Georgiou ML, Misterek MB, Munro CE et al. DAPK2 is a novel modulator of TRAIL-induced apoptosis. Cell Death Differ 2014; 21: 1780-1791.
10. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61: 3225-3229.
11. Katzenellenbogen RA, Baylin SB, Herman JG. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 1999; 93: 4347-4353.
12. Rizzi M, Tschan MP, Britschgi C, Britschgi A, Hugli B, Grob TJ et al. The death-Associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. J Leukoc Biol 2007; 81: 1599-1608.
13. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003; 552: 335-344.
14. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 1996; 86: 147-157.
15. Bonito NA, Drechsler J, Stoecker S, Carmo CR, Seckl MJ, Hermanns HMet al. Control of gp130 expression by the mitogen-Activated protein kinase ERK2. Oncogene 2013; 33: 2255-2263.
16. Humbert M, Federzoni EA, Britschgi A, Schlafli AM, Valk PJ, Kaufmann T et al. The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPalpha during granulocytic differentiation but repressed by PML-RARalpha in APL. J Leukoc Biol 2014; 95: 83-93.
17. Tur MK, Neef I, Jost E, Galm O, Jager G, Stocker M et al. Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells. J Immunother 2009; 32: 431-441.
18. Bialik S, Kimchi A. The death-Associated protein kinases: Structure, function, and beyond. Annu Rev Biochem 2006; 75: 189-210.
19. Son Y, Kim S, Chung HT, Pae HO. Reactive oxygen species in the activation of MAP kinases. Methods Enzymol 2013; 528: 27-48.
20. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005; 120: 483-495.
21. Nishitoh H. CHOP is a multifunctional transcription factor in the ER stress response. J Biochem 2012; 151: 217-219.
22. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev 1999; 13: 1211-1233.
23. Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK. ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 2012; 8: 1462-1476.
24. Lum MG, Nagley P. Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release. J Cell Sci 2003; 116: 1437-1447.
25. Heiskanen KM, BhatMB, Wang HW, Ma J, Nieminen AL.Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J Biol Chem 1999; 274: 5654-5658.
26. Rich PR. The molecular machinery of Keilin's respiratory chain. Biochem Soc Trans 2003; 31: 1095-1105.
27. Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
28. Kirsch M, De Groot H. NAD(P)H, a directly operating antioxidant? FASEB J 2001; 15: 1569-1574.
29. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. The changing faces of glutathione, a cellular protagonist. Biochemical Pharmacol 2003; 66: 1499-1503.
30. Brigelius-Flohe R, Maiorino M. Glutathione peroxidases. Biochim Biophys Acta 2013; 1830: 3289-3303.
31. Shoval Y, Berissi H, Kimchi A, Pietrokovski S. New modularity of DAP-kinases: Alternative splicing of the DRP-1 gene produces a ZIPk-like isoform. PLoS One 2011; 6: E17344.
32. Gozuacik D, Kimchi A. DAPk protein family and cancer. Autophagy 2006; 2: 74-79.
33. Noda M, Yamashita S, Takahashi N, Eto K, Shen LM, Izumi K et al. Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription. J Biol Chem 2002; 277: 41817-41826.
34. Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nature reviews. Drug Discov 2013; 12: 931-947.
35. Rassool FV, Gaymes TJ, Omidvar N, Brady N, Beurlet S, Pla M et al. Reactive oxygen species, DNA damage, and error-prone repair: A model for genomic instability with progression in myeloid leukemia? Cancer Res 2007; 67: 8762-8771.
36. He L, Luo L, Proctor SJ, Middleton PG, Blakely EL, Taylor RW et al. Somatic mitochondrial DNA mutations in adult-onset leukaemia. Leukemia 2003; 17: 2487-2491.
37. Ber Y, Shiloh R, Gilad Y, Degani N, Bialik S, Kimchi A. DAPK2 is a novel regulator of mTORC1 activity and autophagy. Cell Death Differ 2014; 22: 465-475.
38. Monroe DG, Getz BJ, Johnsen SA, Riggs BL, Khosla S, Spelsberg TC. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta. J Cell Biochem 2003; 90: 315-326.
39. Watling D, Carmo CR, Kerr IM, Costa-Pereira AP. Multiple kinases in the interferon-gamma response. Proc Natl Acad Sci USA 2008; 105: 6051-6056.