Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L's leaf: In vitro and in vivo approach

Biomedicine and Pharmacotherapy

Volumn 84, Issue , 2016, Pages 415-422

  Chakroun, Mouna ^a   Khemakhem, Bassem ^a,b   Mabrouk, Hazem Ben ^c   El Abed, Hanen ^a   Makni, Mohamed ^a   Bouaziz, Mohamed ^d   Drira, Noureddine ^a   Marrakchi, Naziha ^c   Mejdoub, Hafedh ^a  

^a University of Sfax   (Tunisia)

^b UNIVERSITY OF GABES   (Tunisia)

^c PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^d UNIVERSITY OF SFAX   (Tunisia)

Author keywords

Antidiabetic activity; Cytotoxic activity; IGR 39 cancer cell lines; LC MS MS analysis; Phoenix dactylifera L. s leaves; Glucosidase and Amylase inhibitors

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE; AMYLASE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; APIGENIN DI C HEXOSIDE; DIHEXOSYL QUERCETIN; EPICATECHIN 3 GALLATE; FLAVONOID; GLUCOSE; ISOORIENTIN; PHENOL DERIVATIVE; PHOENIX DACTYLIFERA EXTRACT; PLANT EXTRACT; PROCYANIDIN; QUERCITRIN; UNCLASSIFIED DRUG; PLANT MEDICINAL PRODUCT; POLYPHENOL;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATE (FRUIT); DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MELANOMA CELL LINE; MOUSE; MTT ASSAY; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME; ANIMAL; CELL DEATH; CHEMISTRY; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; ENZYME ASSAY; METABOLISM; PHOENIX (PLANT); PHYTOTHERAPY; POSTPRANDIAL STATE; TUMOR CELL LINE;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENZYME ASSAYS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; MICE; PHOENICEAE; PHYTOCHEMICALS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; POLYPHENOLS; POSTPRANDIAL PERIOD; TANDEM MASS SPECTROMETRY;

EID: 84988661165     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.09.062     Document Type: Article

References (47)

1. [1] Ponnusamy, S., Ravindran, R., Zinjarde, S., Bhargava, S., Ravi Kumar, A., Evaluation of traditional indian antidiabetic mdicinal plants for human pancreatic amylase inhibitory effect in vitro. BMC Complement. Altern. Med. 10 (2011), 515–647.
2. [2] Eichler, H.G., Korn, A., Gasic, S., The effect of a new specific α-amylase inhibitor on post-prandial glucose and insulin excursions in normal and type 2 (non-insulindependent) diabetic patients. J. Diabetes Res. 26 (1984), 278–281.
3. [3] Alberti, K.G.M.M., Zimmet, P.Z., Definition, diagnosis and classification of diabetes mellitus and its complications part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. J. Diabetic Med. 15 (1998), 539–553.
4. [4] International Diabetes Federation, Atlas. 5th ed., 2012 (update).
5. [5] Bailey, C.J., New approaches to the pharmacotherapy of diabetes. Textbook of Diabetes, 2003, Blackwell Scientific Publications, Ltd., Oxford, UK, 73.1–73.21.
6. [6] Carpio, G.R.A., Fonseca, V.A., Update on safety issues related to antihyperglycemic therapy. Diabetes Spectr. 27 (2014), 92–100.
7. [7] Lutz, S.Z., Staiger, H., Fritsche, A., Haring, H.U., Antihyperglycaemic therapies and cancer risk. Diabetes Vasc. Dis. Res. 11:6 (2014), 371–389.
8. [8] Garcia-Jimenez, C., Garcia-Martinez, J.M., Chocarro-Calvo, A., De la Vieja, A., A new link between diabetes and cancer: enhanced WNT/beta catenin signaling by high glucose. J. Mol. Endocrinol. 52:1 (2014), R51–R66.
9. [9] Jianbo, X., Tingting, C., Hui, C., Flavonoid glycosylation and biological benefits. Biotechnol. Adv., 06821, 2014, 05.004.
10. [10] Hasthi, V.A., Babu, A., Natesan, R., Kallur, P.A., Pemaiah, B., Sethuraman, S., Mahadevan, V., Isolation and in silico evaluation of antidiabetic molecules of (Cynodon dactylon L.). J. Mol. Graph. Model. 39 (2013), 87–97.
11. [11] Baliga, M.S., Baliga, B.R.V., Kandathil, S.M., Bhat, H.P., Vayalil, P.K., A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Int. Food Res. 44 (2011), 1812–1822.
12. [12] Singleton, V.L., Rossi, J.A., Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Viticult. 16 (1965), 144–158.
13. [13] Zhishen, J., Mengcheng, T., Jianming, W., Research on antioxidant activity of flavonoids from natural materials. J. Food Chem. 64 (1999), 555–559.
14. [14] Kite, G.C., Stoneham, C.A., Veitch, N.C., Flavonol tetraglycosides and other constituents from leaves of (Styphnolobium japonicum) (Leguminosae) and related taxa. Phytochemistry 68 (2007), 1407–1416.
15. [15] Hansawasdi, C., Kawabata, J., Kasai, T., α-Amylase inhibitors from Roselle (Hibiscus sabdriffa Linn.) tea. Biosci. Biotechnol. Biochem. 64 (2000), 1041–1043.
16. [16] Nishioka, T., Kawabata, J., Aoyama, Y., Baicalein an alpha-glucosidase inhibitor from (Scutellaria baicalensis). J. Nat. Prod. 61 (1998), 1413–1415.
17. [17] Matsuir, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., Matsumoto, K., α-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity. J. Agric. Food Chem. 49 (2001), 1948–1951.
18. [18] Institutional Animal Care and Use Committee, Guideline of Selected Techniques for Rat and Mouse Blood Collection. 1999.
19. [19] Dunn, J.S., McLetchie, N.G.B., Experimental alloxan diabetes in rats. Lancet 2 (1943), 384–387.
20. [20] Boulaaba, K., Mkadmini, S., Tsolmon, J., Han, A., Smaoui, K., In vitro antiproliferative effect of Arthrocnemum indicum extracts on Caco-2 cancer cells through cell cycle control and related phenol LC–TOF–MS identification. Evidence-Based Complementary and Alternative Medicine, 2013.
21. [21] Kriaa, W., Fetoui, H., Makni, M., Zeghal, N., Drira, N.E., Phenolic contents and antioxidant activities of date palm (Phoenix dactylifera L.) leaves. Int. J. Food. Prop. 15 (2012), 1220–1232.
22. [22] Waridel, P., Wolfender, J., Ndjoko, K., Hobby, K.R., Major, H.J., Hostettmann, K., Evaluation of quadrupole time of flight tandem mass spectrometry and iontrap multiple stage mass spectrometry for the differentiation of C-glycosidic flavonoid isomers. J. Chromatogr. A 926 (2001), 29–41.
23. [23] Hong, T., Barberan, A.A., The flavonoid glycosides and procyanidin composition of deglet noor dates (Phoenix dactylifera). J. Agric. Food Chem. 54 (2006), 2405–2411.
24. [24] João, C.C., Characterization of phenolic compounds and antioxidant activity of ethanolic extracts from flowers of (Andryala glandulosa ssp. Varia) (Lowe ex DC.) R. Fern., anendemic species of Macaronesia region. Ind. Crops Prod. 42 (2013), 573–582.
25. [25] Bastos, D.H., Saldanha, L.A., Catharino, R.R., Sawaya, A., Cunha, I.B., Carvalho, P.O., Eberlin, M.N., Phenolic antioxidants identified by ESI–MS from yerba maté (Ilex paraguariensis) and green tea (Camelia sinensis) extracts. Molecules 12 (2007), 423–432.
26. [26] Ademiluyi, A.O., Oboh, G., Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro. Exp. Toxicol. Pathol. 65 (2013), 305–309.
27. [27] Eddine, L.S., Antioxidant, anti-inflammatory and diabetes related enzyme inhibition properties of leaves extract from selected varieties of Phoenyx dactylifera L. Inov. J. Life Sci. 1 (2013), 14–18.
28. [28] Chiasson, J.L., Josse, R.G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., STOP-NIDDM trial research group, acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 359 (2002), 2072–2077.
29. [29] Randhir, R., Kwon, Y.I., Shetty, K., Effect of thermal processing on phenolics, antioxidant activity and health-relevant functionality of select grain sprouts and seedlings. Innovat. Food Sci Emerg. Technol. 9 (2008), 355–364.
30. [30] Manaharan, T., Appleton, D., Cheng, H.M., Palanisamy, U.D., Flavonoids isolated from Syzygium aqueum leaves extract as potential antihyperglycaemic agents. J. Food Chem. 132 (2012), 1802–1807.
31. [31] Yao, X., Zhu, L., Chen, Y., Tian, J., Wang, Y., In vivo and in vitro antioxidant activity and α-glucosidase, α-amylase inhibitory effects of flavonoids from (Cichorium glandulosum) seeds. J. Food Chem. 139 (2013), 59–66.
32. [32] Bansal, P., Paul, P., Mudgal, J., Nayak, P.G., Pannakal, S.T., Priyadarsini, K.I., Unnikrishnan, M.K., Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of (Pilea microphylla L.) in high fat diet/streptozotocin-induced diabetes in mice. Exp. Toxicol. Pathol. J. 64 (2012), 651–658.
33. [33] Havsteen, B.H., The biochemistry and medical significance of the flavonoids. Pharmacol. Therapeut. 96 (2002), 67–202.
34. [34] Cazarolli, L.H., Kappel, V.D., Pereira, D.F., Moresco, H.H., Brighente, I.M.C., Pizzolatti, M.G., Silva, F.R.M.B., Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola. J. Fitoterapia 83 (2012), 1176–1183.
35. [35] Andrade, C.A., Widenfled, H., Anti-hyperglycemic effect of (Opuntia streptacantha Lem). J. Ethnopharmacol. 78 (2011), 145–152.
36. [36] Bacerra-jiménez, J., Andrade, C.A., Effect of (Opunia streptacantha Lem) on alpha-glucosidase activity. J. Ethnopharmacol. 139 (2012), 493–496.
37. [37] Yuka, N., Miyuki, S., Tomoyuki, k., et al. Anti-hyperglycemic effects of verbenaceous plant Clerodendrum Ugandense prain in mice. J. Life Sci. Feed, 8, 2012 (2231–1971).
38. [38] Gondwe, M., Kamadyaapa, D.R., Tufts, M.A., Chuturgoon, A.A., Ojewole, J.A., Musabayane, C.T., Effect of Persea Americana mill (Lauraceae) hydroalcoholic leaf extract on blood glucose and kidney function in streptozotocin-induced diabetic rats and on kidney cell lines of the proximal (LLCPK1) and distal tubules (MDBK). Method Find Exp. Clin. J. 30 (2008), 25–35.
39. [39] Mohammed, S.I., Chopda, M.Z., Patil, R.H., Vishwakarma, K.S., Maheshwari, V.L., In vivo antidiabetic and antioxidant activities of Coccinia grandis leaf extract against streptozotocin induced diabetes in experimental rats. Asian Pac. J. Trop. Dis. 6:4 (2016), 298–304.
40. [40] El-Fouhil, A.F., Ahmed, A.M., Darwish, H.H., Hypoglycemic effect of an extract from date seeds on diabetic rats. Saudi Med. J. 31:7 (2010), 747–751.
41. [41] Kumar, S., Suresh, P.K., Vijayababu, M.R., Arunkumar, A., Arunakaran, J., Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3). J. Ethnopharmacol. 105:1 (2006), 246–250.
42. [42] Wang, C., Mathiyalagan, R., Kim, Y.J., Castro-Aceituno, V., Singh, P., Ahn, S., Yang, D.C., Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities. Int. J. Nanomed., 11, 2016, 3691.
43. [43] Dai, J., Mumper, R.J., Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15 (2010), 7313–7352.
44. [44] Stump, T., Santee, B., Williams, L., Heinze, C., Kunze, R., Amos, S., Simpson, D.S., The Effects of Apigenin on Cell Proliferation and Apoptosis in Glioblastoma Multiforme. 2016.
45. [45] Srivastava, S., Somasagara, R.R., Hegde, M., Nishana, M., K.Tadi, S., Srivastava, M., Raghavan, S.C., Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis. Sci. Rep., 6, 2016, 24049, 10.1038/srep24049.
46. [46] Thanekar, D., Dhodi, J., Gawali, N., Raju, A., Deshpande, P., Degani, M., Juvekar, A., Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala: In vitro, in vivo and in silico approach. S. Afr. J. Bot. 104 (2016), 6–14.
47. [47] Rahmani, A.H., Aly, S.M., Ali, H., Babiker, A.Y., Srikar, S., Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity. Int. J. Clin. Exp. Med., 7(3), 2014.