Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease

Current Opinion in Cardiology

Volumn 31, Issue 6, 2016, Pages 662-669

  Taqueti, Viviany R ^a,b,c   Di Carli, Marcelo F ^a,b,c  

^a Noninvasive Cardiovascular Imaging Program   (United States)

^b Division of Nuclear Medicine and Molecular Imaging   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Coronary artery disease; Coronary flow reserve; Coronary microvascular dysfunction; Ischemic heart disease; Positron emission tomography

Indexed keywords

CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; CORONARY ARTERY DISEASE; CORONARY FLOW RESERVE; CORONARY MICROVASCULAR DYSFUNCTION; DIABETES MELLITUS; DISEASE SEVERITY; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART PERFUSION; HUMAN; INFLAMMATORY DISEASE; ISCHEMIC HEART DISEASE; METABOLIC SYNDROME X; NON INVASIVE PROCEDURE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REVIEW; VULNERABLE POPULATION; BLOOD; CORONARY ARTERY BLOOD FLOW; DIAGNOSTIC IMAGING; FEMALE; FRACTIONAL FLOW RESERVE; HEART; HEART MUSCLE ISCHEMIA; POSITRON EMISSION TOMOGRAPHY; RISK FACTOR;

CORONARY ARTERY DISEASE; CORONARY CIRCULATION; FEMALE; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HEART; HUMANS; MYOCARDIAL ISCHEMIA; POSITRON-EMISSION TOMOGRAPHY; RISK FACTORS;

EID: 84988622731     PISSN: 02684705     EISSN: 15317080     Source Type: Journal    
DOI: 10.1097/HCO.0000000000000339     Document Type: Review

References (49)

1. Gould KL, Johnson NP, Bateman TM, et al. Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol 2013; 62:1639-1653.
2. Ahmadi A, Stone GW, Leipsic J, et al. Prognostic determinants of coronary atherosclerosis in stable ischemic heart disease: anatomy, physiology, or morphology? Circ Res 2016; 119:317-329.
3. Gould KL. Does coronary flow trump coronary anatomy? JACC Cardiovasc Imaging 2009; 2:1009-1023.
4. Topol EJ, Nissen SE. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation 1995; 92:2333-2342.
5. White CW, Wright CB, Doty DB, et al. Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis? N Engl J Med 1984; 310:819-824.
6. Marcus ML, Skorton DJ, Johnson MR, et al. Visual estimates of percent diameter coronary stenosis: 'a battered gold standard'. J Am Coll Cardiol 1988; 11:882-885.
7. Uren NG, Melin JA, De Bruyne B, et al. Relation between myocardial blood flow and the severity of coronary-artery stenosis. N Engl J Med 1994; 330:1782-1788.
8. Arnett EN, Isner JM, Redwood DR, et al. Coronary artery narrowing in coronary heart disease: comparison of cineangiographic and necropsy findings. Ann Intern Med 1979; 91:350-356.
9. Vlodaver Z, Frech R, Van Tassel RA, Edwards JE. Correlation of the antemortem coronary arteriogram and the postmortem specimen. Circulation 1973; 47:162-169.
10. Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007; 356:1503-1516.
11. Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009; 360:2503-2515.
12. Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009; 360:213-224.
13. Hachamovitch R. Does ischemia burden in stable coronary artery disease effectively identify revascularization candidates? Ischemia burden in stable coronary artery disease effectively identifies revascularization candidates. Circ Cardiovasc Imaging 2015; 8:8.
14. Stone GW, Hochman JS, Williams DO, et al. Medical therapy with versus without revascularization in stable patients with moderate and severe ischemia: the case for community equipoise. J Am Coll Cardiol 2016; 67:81-99.
15. Kobayashi Y, Nam CW, Tonino PA, et al. The prognostic value of residual coronary stenoses after functionally complete revascularization. J Am Coll Cardiol 2016; 67:1701-1711.
16. Johnson NP, Gould KL, Di Carli MF, Taqueti VR. Invasive FFR and noninvasive CFR in the evaluation of ischemia: what is the future? J Am Coll Cardiol 2016; 67:2772-2788.
17. Motwani M, Motlagh M, Gupta A, et al. Reasons and implications of agreements and disagreements between coronary flow reserve, fractional flowreserve, and myocardial perfusion imaging. J Nucl Cardiol 2015. [Epub ahead of print]
18. Ibrahim T, Nekolla SG, Schreiber K, et al. Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. J Am Coll Cardiol 2002; 39:864-870.
19. Caiati C, Montaldo C, Zedda N, et al. New noninvasive method for coronary flow reserve assessment: contrast-enhanced transthoracic second harmonic echo Doppler. Circulation 1999; 99:771-778.
20. El Fakhri G, Kardan A, Sitek A, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J Nucl Med 2009; 50:1062-1071.
21. El Fakhri G, Sitek A, Guerin B, et al. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. J Nucl Med 2005; 46:1264-1271.
22. Gewirtz H, Dilsizian V. Integration of quantitative positron emission tomography absolute myocardial blood flow measurements in the clinical management of coronary artery disease. Circulation 2016; 133:2180-2196.
23. Murthy VL, Lee BC, Sitek A, et al. Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with 82Rb PET. J Nucl Med 2014; 55:1952-1958.
24. Slomka PJ, Alexanderson E, Jacome R, et al. Comparison of clinical tools for measurements of regional stress and rest myocardial blood flow assessed with 13N-ammonia PET/CT. J Nucl Med 2012; 53:171-181.
25. Moody JB, Lee BC, Corbett JR, et al. Precision and accuracy of clinical quantification of myocardial blood flow by dynamic PET: a technical perspective. J Nucl Cardiol 2015; 22:935-951.
26. Taqueti VR, Di Carli MF. Radionuclide myocardial perfusion imaging for the evaluation of patients with known or suspected coronary artery disease in the era of multimodality cardiovascular imaging. Prog Cardiovasc Dis 2015; 57:644-653.
27. Murthy VL, Naya M, Foster CR, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 2011; 124:2215-2224.
28. Naya M, Murthy VL, Taqueti VR, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014; 55:248-255.
29. Ziadi MC, Dekemp RA, Williams KA, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol 2011; 58:740-748.
30. Fukushima K, Javadi MS, Higuchi T, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med 2011; 52:726-732.
31. Herzog BA, Husmann L, Valenta I, et al. Long-term prognostic value of 13Nammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol 2009; 54:150-156.
32. Taqueti VR, Hachamovitch R, Murthy VL, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 2015; 131:19-27.
33. Nahser PJ Jr, Brown RE, Oskarsson H, et al. Maximal coronary flow reserve and metabolic coronary vasodilation in patients with diabetes mellitus. Circulation 1995; 91:635-640.
34. Murthy VL, Naya M, Foster CR, et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation 2012; 126:1858-1868.
35. Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol 2004; 11:171-185.
36. Murthy VL, Naya M, Foster CR, et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging 2012; 5:1025-1034.
37. Shah NR, Charytan DM, Murthy VL, et al. Prognostic value of coronary flow reserve in patients with dialysis-dependent ESRD. J Am Soc Nephrol 2016; 27:1823-1829.
38. Yiu KH, de Graaf FR, Schuijf JD, et al. Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography. Am J Cardiol 2011; 108:968-972.
39. Taqueti VR, Everett BM, Murthy VL, et al. Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 2015; 131:528-535.
40. Murthy VL, Naya M, Taqueti VR, et al. Effects of sex on coronary microvascular dysfunction and cardiac outcomes. Circulation 2014; 129: 2518-2527.
41. Naya M, Murthy VL, Foster CR, et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol 2013; 61:2098-2106.
42. Taqueti VR, Shaw LJ, Murthy VL, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with impaired coronary flow reserve from diffuse versus obstructive coronary artery disease [abstract]. Circulation 2015; 132:; 13679.
43. Taqueti VR, Dorbala S. The role of positron emission tomography in the evaluation of myocardial ischemia in women. J Nucl Cardiol 2016. [Epub ahead of print]
44. Paulus WJ, Tschope C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 2013; 62:263-271.
45. Taqueti VR, Murthy VL, Hainer J, et al. Coronary vasomotor dysfunction, myocardial injury and diastolic dysfunction in patients without overt coronary artery disease. J Am Coll Cardiol 2014; 63:. [abstract 1015]
46. Di Carli MF, Charytan D, McMahon GT, et al. Coronary circulatory function in patients with the metabolic syndrome. J Nucl Med 2011; 52: 1369-1377.
47. Avina-Zubieta JA, Choi HK, Sadatsafavi M, et al. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum 2008; 59:1690-1697.
48. Osto E, Piaserico S, Maddalozzo A, et al. Impaired coronary flow reserve in young patients affected by severe psoriasis. Atherosclerosis 2012; 221:113-117.
49. Recio-Mayoral A, Rimoldi OE, Camici PG, Kaski JC. Inflammation and microvascular dysfunction in cardiac syndrome X patients without conventional risk factors for coronary artery disease. JACC Cardiovasc Imaging 2013; 6:660-667.