Comparison of clinical tools for measurements of regional stress and rest myocardial blood flow assessed with 13N-ammonia PET/CT

Journal of Nuclear Medicine

Volumn 53, Issue 2, 2012, Pages 171-181

  Slomka, Piotr J ^a   Alexanderson, Erick ^b,c   Jácome, Rodrigo ^b   Jiménez, Moises ^b,c   Romero, Edgar ^b   Meave, Aloha ^b,c   Le Meunier, Ludovic ^d   Dalhbom, Magnus ^e   Berman, Daniel S ^a   Germano, Guido ^a   Schelbert, Heinrich ^e  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^d Siemens Healthcare Molecular Imaging   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Myocardial blood flow; NH 3; Perfusion; PET CT; Quantitative analysis

Indexed keywords

ADENOSINE; AMMONIA N 13;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; COMPARTMENT MODEL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER PROGRAM; CONTROLLED STUDY; FEMALE; FRACTIONAL FLOW RESERVE; HEART LEFT VENTRICLE; HEART MUSCLE BLOOD FLOW; HEART PERFUSION; HEART STRESS; HUMAN; IMAGE PROCESSING; IMAGE RECONSTRUCTION; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION ATTENUATION; REFERENCE VALUE; REST; RETROSPECTIVE STUDY; THORAX PAIN;

AMMONIA; CORONARY CIRCULATION; FEMALE; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MYOCARDIAL PERFUSION IMAGING; NITROGEN RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; REST; RETROSPECTIVE STUDIES; SOFTWARE; STRESS, PHYSIOLOGICAL;

EID: 84856803974     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.095398     Document Type: Article

References (24)

1. Di Carli MF, Dorbala S, Meserve J, El Fakhri G, Sitek A, Moore S. Clinical myocardial perfusion PET/CT. J Nucl Med. 2007;48:783-793.
2. Klein R, Renaud J, Ziadi M, et al. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. J Nucl Cardiol. 2010;17:600-616.
3. 13N-labeled ammonia and positron emission tomography. J Nucl Cardiol. 1996;3:494-507.
4. Choi Y, Hawkins S-C, Hawkins R, et al. A simplified method for quantification of myocardial blood flow using nitrogen-14 ammonia and dynamic PET. J Nucl Med. 1993;34:488-497.
5. Hutchins GD, Schwaiger M, Rosenspire K, Krivokapich J, Schelbert H, Kuhl D. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15:1032-1042.
6. Wilson PW, D'Agostino R, Levy D, Belanger A, Silbershatz H, Kannel W. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837-1847.
7. 82Rb cardiac PET [abstract]. J Nucl Med. 2009;50(suppl 2):217P.
8. Germano G, Kiat H, Kavanagh P, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT images. J Nucl Med. 1995;36:2138-2147.
9. Choi Y, Hawkins S-C, Hawkins R, et al. Quantification of myocardial blood flow using N-13-ammonia and PET: comparison of tracer models. J Nucl Med. 1999;40:1045-1055.
10. Martinez-Möller A, Zikic D, Botnar R, et al. Dual cardiac-respiratory gated PET: implementation and results from a feasibility study. Eur J Nucl Med Mol Imaging. 2007;34:1447-1454.
11. Townsend D, Jakoby B, Long MJ, et al. Performance and clinical workflow of a new combined PET/CT scanner [abstract]. J Nucl Med. 2007;48(suppl 2):437P.
12. 18F]fluoro- 2-deoxy-d-glucose studies. J Nucl Med. 1991;32:733-738.
13. Parkash R, DeKemp R, Ruddy T, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol. 2004;11:440-449.
14. Cecchi F, Olivotto L, Gistri R, Lorenzoni R, Chiriatti G, Camici P. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003;349:1027-1035.
15. Schindler TH, Schelbert H, Quercioli A, Dilsizian V. Cardiac PET imaging for the detection and monitoring of coronary artery disease and microvascular health. JACC Cardiovasc Imaging. 2010;3:623-640.
16. Camici PG, Rimoldi O. The clinical value of myocardial blood flow measurement. J Nucl Med. 2009;50:1076-1087.
17. Beanlands RS, Ziadi M, Williams K. Quantification of myocardial flow reserve using positron emission imaging the journey to clinical use. J Am Coll Cardiol. 2009;54:157-159.
18. 13N-ammonia PET. J Nucl Med. 2009;50:1062-1071.
19. Klein R, Beanlands R, DeKemp R. Quantification of myocardial blood flow and flow reserve: technical aspects. J Nucl Cardiol. 2010;17:555-570.
20. Nuyts H, Maes A, Vrolix M, et al. Three-dimensional correction for spill-over and recovery of myocardial PET images. J Nucl Med. 1996;37:767-774.
21. 82Rb PET performed with CT- and transmission CT-based attenuation correction. J Nucl Med. 2008;49:1992-1998.
22. 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765-1774.
23. Kajander S, Joutsiniemi E, Saraste M, et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation. 2010;122:603-613.
24. Czernin J, Muller P, Chan SB, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation. 1993;88:62-69.