Improved cardiac risk assessment with noninvasive measures of coronary flow reserve

Circulation

Volumn 124, Issue 20, 2011, Pages 2215-2224

  Murthy, Venkatesh L ^a,b   Naya, Masanao ^b   Foster, Courtney R ^c   Hainer, Jon ^f   Gaber, Mariya ^f   Di Carli, Gilda ^f   Blankstein, Ron ^f   Dorbala, Sharmila ^a,b,c   Sitek, Arkadiusz ^c   Pencina, Michael J ^d,e   Di Carli, Marcelo F ^a,b,c  

^a Noninvasive Cardiovascular Imaging Program   (United States)

^b Departments of Medicine and Radiology   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD CLINICAL RESEARCH INSTITUTE   (United States)

^e BOSTON UNIVERSITY   (United States)

^f NONE

Author keywords

atherosclerosis; blood flow; coronary artery disease; imaging; ischemia; microcirculation; nuclear medicine

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY FLOW RESERVE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEART DEATH; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYOCARDIAL PERFUSION IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SURVIVAL;

AGED; AGED, 80 AND OVER; BLOOD FLOW VELOCITY; CARDIOVASCULAR DISEASES; CORONARY CIRCULATION; DEATH; EXERCISE TEST; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL PERFUSION IMAGING; POSITRON-EMISSION TOMOGRAPHY; RISK ASSESSMENT;

EID: 81355146433     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.050427     Document Type: Article

References (37)

1. Gibbons RJ, Chatterjee K, Daley J, Douglas JS, Fihn SD, Gardin JM, Grunwald MA, Levy D, Lytle BW, O'Rourke RA, Schafer WP, Williams SV, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A Jr, Russell RO, Ryan TJ, Smith SC Jr. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol. 1999;33:2092-2197.
2. Giri S, Shaw LJ, Murthy DR, Travin MI, Miller DD, Hachamovitch R, Borges-Neto S, Berman DS, Waters DD, Heller GV. Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease. Circulation. 2002;105:32-40. (Pubitemid 34049139)
3. Al-Mallah MH, Hachamovitch R, Dorbala S, Di Carli MF. Incremental prognostic value of myocardial perfusion imaging in patients referred to stress single-photon emission computed tomography with renal dysfunction. Circ Cardiovasc Imaging. 2009;2:429-436.
4. Quyyumi AA, Dakak N, Andrews NP, Husain S, Arora S, Gilligan DM, Panza JA, Cannon RO. Nitric oxide activity in the human coronary circulation: impact of risk factors for coronary atherosclerosis. J Clin Invest. 1995;95:1747-1755.
5. Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, Selwyn AP. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation. 1989;80:458-465. (Pubitemid 19231379)
6. Laine H, Raitakari OT, Niinikoski H, Pitkänen O-P, Iida H, Viikari J, Nuutila P, Knuuti J. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol. 1998;32:147-153. (Pubitemid 28351056)
7. Yokoyama I, Momomura S, Ohtake T, Yonekura K, Nishikawa J, Sasaki Y, Omata M. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1997;30:1472-1477. (Pubitemid 27486464)
8. Iwado Y, Yoshinaga K, Furuyama H, Ito Y, Noriyasu K, Katoh C, Kuge Y, Tsukamoto E, Tamaki N. Decreased endothelium-dependent coronary vasomotion in healthy young smokers. Eur J Nucl Med Mol Imaging. 2002;29:984-990.
9. Halcox JPJ, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KRA, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-658. (Pubitemid 34851922)
10. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899-1906. (Pubitemid 30225269)
11. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948-954. (Pubitemid 30131694)
12. Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, van 't Veer M, Klauss V, Manoharan G, Engstrøm T, Oldroyd KG, Ver Lee PN, Mac-Carthy PA, Fearon WF. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360: 213-224.
13. El Fakhri G, Sitek A, Guerin B, Kijewski MF, Di Carli MF, Moore SC. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. J Nucl Med. 2005;46:1264-1271. (Pubitemid 43733474)
14. Senthamizhchelvan S, Bravo PE, Lodge MA, Merrill J, Bengel FM, Sgouros G. Radiation Dosimetry of 82Rb in Humans Under Pharma-cologic Stress. J Nucl Med. 2011;52:485-491.
15. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539-542. (Pubitemid 34262671)
16. El Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli MF. Reproducibility and accuracy of quantitative myocardial blood flow assessment with 82Rb PET: comparison with 13N-ammonia PET. J Nucl Med. 2009;50: 1062-1071.
17. Sitek A, Gullberg GT, Huesman RH. Correction for ambiguous solutions in factor analysis using a penalized least squares objective. IEEE Trans Med Imaging. 2002;21:216-225. (Pubitemid 34630839)
18. Nieto FJ, Coresh J. Adjusting survival curves for confounders: a review and a new method. Am J Epidemiol. 1996;143:1059-1068. (Pubitemid 26140334)
19. Hachamovitch R, Di Carli MF. Methods and limitations of assessing new noninvasive tests: part ii: outcomes-based validation and reliability assessment of noninvasive testing. Circulation. 2008;117:2793-2801. (Pubitemid 351770460)
20. Hosmer DW, Hosmer T, Le Cessie S, Lemeshow S. A comparison of goodness-of-fit tests for the logistic regression model. Stat Med. 1997; 16:965-980. (Pubitemid 27198985)
21. Pencina MJ, D'Agostino RB. Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Stat Med. 2004;23:2109-2123. (Pubitemid 38968032)
22. Antolini L, Nam B-H, D'Agostino RB. Inference on correlated discrimination measures in survival analysis: a nonparametric approach. Commun Stat Theory Methods. 2004;33:2117-2135.
23. Pencina MJ, D' Agostino RB Sr, D' Agostino RB Jr, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27:157-172. (Pubitemid 351193639)
24. Pryor DB, Shaw L, McCants CB, Lee KL, Mark DB, Harrell FE, Muhlbaier LH, Califf RM. Value of the history and physical in identifying patients at increased risk for coronary artery disease. Ann Intern Med. 1993;118:81-90.
25. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368: 666-678. (Pubitemid 44223694)
26. Steyerberg EW, Pencina MJ. Reclassification calculations for persons with incomplete follow-up. Ann Intern Med. 2010;152:195-196.
27. Kajander S, Joutsiniemi E, Saraste M, Pietila M, Ukkonen H, Saraste A, Sipila HT, Teras M, Maki M, Airaksinen J, Hartiala J, Knuuti J. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation. 2010;122:603-613.
28. Parkash R, deKemp RA, Ruddy TD, Kitsikis A, Hart R, Beauchesne L, Williams K, Davies RA, Labinaz M, Beanlands RSB. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol. 2004;11:440-449. (Pubitemid 39115288)
29. Tio RA, Dabeshlim A, Siebelink H-MJ, de Sutter J, Hillege HL, Zee-bregts CJ, Dierckx RAJO, van Veldhuisen DJ, Zijlstra F, Slart RHJA. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med. 2009;50:214-219.
30. Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, Burkhard N, Wyss CA, Kaufmann PA. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography: added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150-156.
31. Fukushima K, Javadi MS, Higuchi T, Lautamaki R, Merrill J, Nekolla SG, Bengel FM. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med. 2011;52:726-732.
32. Ziadi MC, deKemp RA, Williams KA, Guo A, Chow BJW, Renaud JM, Ruddy TD, Sarveswaran N, Tee RE, Beanlands RSB. Impaired myo-cardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol. 2011;58:740-748.
33. Zeiher A, Drexler H, Wollschlager H, Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation. 1991;84: 1984-1992.
34. von Mering GO, Arant CB, Wessel TR, McGorray SP, Bairey Merz CN, Sharaf BL, Smith KM, Olson MB, Johnson BD, Sopko G, Handberg E, Pepine CJ, Kerensky RA. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109:722-725. (Pubitemid 38222890)
35. Cecchi F, Olivotto I, Gistri R, Lorenzoni R, Chiriatti G, Camici PG. Coronary microvascular dysfunction and prognosis in hypertrophic car-diomyopathy. N Engl J Med. 2003;349:1027-1035. (Pubitemid 37087617)
36. Dorbala S, Hachamovitch R, Curillova Z, Thomas D, Vangala D, Kwong RY, Di Carli MF. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF. JACC Cardiovasc Imaging. 2009;2:846-854.
37. Cook NR. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation. 2007;115:928-935. (Pubitemid 46294733)