Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A novel mechanism of inflammasome regulation

Journal of Innate Immunity

Volumn 9, Issue 1, 2017, Pages 65-82

  Nurmi, Katariina ^a   Kareinen, Ilona ^a   Virkanen, Juhani ^b   Rajamäki, Kristiina ^a   Kouri, Vesa Petteri ^c   Vaali, Kirsi ^d   Levonen, Anna Liisa ^e   Fyhrquist, Nanna ^f   Matikainen, Sampsa ^f   Kovanen, Petri T ^f   Eklund, Kari K ^d  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b Department of Geosciences and Geography ^*  (Finland)

^c Faculty of Medicine   (Spain)

^d UNIVERSITY OF HELSINKI   (Finland)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

Autophagy; Cobalt protoporphyrin; Heme oxygenase 1; Hemin; Inflammasome; Macrophage

Indexed keywords

CASPASE; CRYOPYRIN; HEMIN; INFLAMMASOME; INTERLEUKIN 1BETA; PROTOPORPHYRIN COBALT; URATE; NLRP3 PROTEIN, MOUSE; PROTOPORPHYRIN; URIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; MOUSE; NONHUMAN; PERITONITIS; PROTEIN DOMAIN; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; IMMUNOLOGY; IMMUNOMODULATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; HEMIN; HUMANS; IMMUNOMODULATION; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PERITONITIS; PROTOPORPHYRINS; URIC ACID;

EID: 84988613648     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000448894     Document Type: Article

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