메뉴 건너뛰기




Volumn 5, Issue 10, 2016, Pages 1307-1318

Hepatocyte growth factor is required for mesenchymal stromal cell protection against bleomycin-induced pulmonary fibrosis

Author keywords

Antiapoptotic; Fibrosis; Hepatocyte growth factor; Mesenchymal stromal cell

Indexed keywords

BLEOMYCIN; CYCLOOXYGENASE 2; CYTOPROTECTIVE AGENT; DNA NUCLEOTIDYLEXOTRANSFERASE; PHOSPHATE BUFFERED SALINE; SCATTER FACTOR; SHORT HAIRPIN RNA; ANTINEOPLASTIC ANTIBIOTIC;

EID: 84988569326     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2015-0337     Document Type: Article
Times cited : (98)

References (64)
  • 1
    • 60649102339 scopus 로고    scopus 로고
    • Pulmonary fibrosis: Pathogenesis, etiology and regulation
    • Wilson MS, Wynn TA. Pulmonary fibrosis: Pathogenesis, etiology and regulation. Mucosal Immunol 2009; 2: 103-121.
    • (2009) Mucosal Immunol , vol.2 , pp. 103-121
    • Wilson, M.S.1    Wynn, T.A.2
  • 3
    • 85046909189 scopus 로고    scopus 로고
    • Wound healing: Biologic features and approaches to maximize healing trajectories
    • Robson MC, Steed DL, Franz MG. Wound healing: Biologic features and approaches to maximize healing trajectories. Curr Probl Surg 2001; 38: 72-140.
    • (2001) Curr Probl Surg , vol.38 , pp. 72-140
    • Robson, M.C.1    Steed, D.L.2    Franz, M.G.3
  • 4
    • 0017742026 scopus 로고
    • The mechanism of the bleomycin-induced cleavage of DNA
    • Lown JW, Sim SK. The mechanism of the bleomycin-induced cleavage of DNA. Biochem Biophys Res Commun 1977; 77: 1150-1157.
    • (1977) Biochem Biophys Res Commun , vol.77 , pp. 1150-1157
    • Lown, J.W.1    Sim, S.K.2
  • 5
    • 84928538044 scopus 로고    scopus 로고
    • Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
    • Cahill EF, Tobin LM, Carty F et al. Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells. Stem Cell Res Ther 2015; 6: 19.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 19
    • Cahill, E.F.1    Tobin, L.M.2    Carty, F.3
  • 6
    • 84872144085 scopus 로고    scopus 로고
    • Mechanisms of mesenchymal stromal cell immunomodulation
    • English K. Mechanisms of mesenchymal stromal cell immunomodulation. Immunol Cell Biol 2013; 91: 19-26.
    • (2013) Immunol Cell Biol , vol.91 , pp. 19-26
    • English, K.1
  • 7
    • 84876086426 scopus 로고    scopus 로고
    • Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graftversus- host disease
    • Tobin LM, Healy ME, English K et al. Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graftversus- host disease. Clin Exp Immunol 2013; 172: 333-348.
    • (2013) Clin Exp Immunol , vol.172 , pp. 333-348
    • Tobin, L.M.1    Healy, M.E.2    English, K.3
  • 8
    • 84888072366 scopus 로고    scopus 로고
    • IFN-g stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro
    • Noone C, Kihm A, English K et al. IFN-g stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro. Stem Cells Dev 2013; 22: 3003-3014.
    • (2013) Stem Cells Dev , vol.22 , pp. 3003-3014
    • Noone, C.1    Kihm, A.2    English, K.3
  • 9
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006; 98: 1076-1084.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 10
    • 44849121129 scopus 로고    scopus 로고
    • Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    • Chen L, Tredget EE,WuPY et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008; 3: e1886.
    • (2008) PLoS One , vol.3 , pp. 1886
    • Chen, L.1    Tredget, E.E.2    Wu, P.Y.3
  • 11
    • 0037478581 scopus 로고    scopus 로고
    • Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    • Ortiz LA, Gambelli F, McBride C et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003; 100: 8407-8411.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8407-8411
    • Ortiz, L.A.1    Gambelli, F.2    McBride, C.3
  • 12
    • 24344448730 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    • Rojas M, Xu J, Woods CR et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung.AmJ Respir Cell Mol Biol 2005; 33: 145-152.
    • (2005) AmJ Respir Cell Mol Biol , vol.33 , pp. 145-152
    • Rojas, M.1    Xu, J.2    Woods, C.R.3
  • 13
    • 34547402979 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stemcells during lung injury
    • Ortiz LA, DutreilM, FattmanCet al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stemcells during lung injury. Proc Natl Acad Sci USA 2007; 104: 11002-11007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11002-11007
    • Ortiz, L.A.1    Dutreil, M.2    Fattman, C.3
  • 14
    • 77955881563 scopus 로고    scopus 로고
    • Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis
    • Maher TM, Evans IC, Bottoms SE et al. Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2010; 182: 73-82.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 73-82
    • Maher, T.M.1    Evans, I.C.2    Bottoms, S.E.3
  • 15
    • 16344367737 scopus 로고    scopus 로고
    • HGF reduces advancing lung fibrosis in mice: A potential role for MMP-dependent myofibroblast apoptosis
    • Mizuno S, Matsumoto K, Li MY et al. HGF reduces advancing lung fibrosis in mice: A potential role for MMP-dependent myofibroblast apoptosis. FASEB J 2005; 19: 580-582.
    • (2005) FASEB J , vol.19 , pp. 580-582
    • Mizuno, S.1    Matsumoto, K.2    Li, M.Y.3
  • 16
    • 58149326737 scopus 로고    scopus 로고
    • Bonemarrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • Németh K, Leelahavanichkul A, Yuen PS et al. Bonemarrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15: 42-49.
    • (2009) Nat Med , vol.15 , pp. 42-49
    • Németh, K.1    Leelahavanichkul, A.2    Yuen, P.S.3
  • 17
    • 79952042164 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    • Kavanagh H, Mahon BP. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 2011; 66: 523-531.
    • (2011) Allergy , vol.66 , pp. 523-531
    • Kavanagh, H.1    Mahon, B.P.2
  • 18
    • 79953787534 scopus 로고    scopus 로고
    • The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation
    • Jun D, Garat C, West J et al. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells 2011; 29: 725-735.
    • (2011) Stem Cells , vol.29 , pp. 725-735
    • Jun, D.1    Garat, C.2    West, J.3
  • 20
    • 0027344558 scopus 로고
    • Roles of HGF as a pleiotropic factor in organ regeneration
    • Matsumoto K, Nakamura T. Roles of HGF as a pleiotropic factor in organ regeneration. EXS 1993; 65: 225-249.
    • (1993) EXS , vol.65 , pp. 225-249
    • Matsumoto, K.1    Nakamura, T.2
  • 21
    • 14444271598 scopus 로고    scopus 로고
    • Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin
    • Yaekashiwa M, Nakayama S, Ohnuma K et al. Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med 1997; 156: 1937-1944.
    • (1997) A morphologic study. Am J Respir Crit Care Med , vol.156 , pp. 1937-1944
    • Yaekashiwa, M.1    Nakayama, S.2    Ohnuma, K.3
  • 22
    • 0034524385 scopus 로고    scopus 로고
    • Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis
    • Dohi M, Hasegawa T, Yamamoto K et al. Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000; 162: 2302-2307.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2302-2307
    • Dohi, M.1    Hasegawa, T.2    Yamamoto, K.3
  • 23
    • 0023914820 scopus 로고
    • Simple methodof estimating severity ofpulmonary fibrosis onanumerical scale
    • Ashcroft T, Simpson JM, Timbrell V. Simple methodof estimating severity ofpulmonary fibrosis onanumerical scale. JClinPathol1988; 41: 467-470.
    • (1988) JClinPathol , vol.41 , pp. 467-470
    • Ashcroft, T.1    Simpson, J.M.2    Timbrell, V.3
  • 24
    • 34447298069 scopus 로고    scopus 로고
    • Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • Ryan JM, Barry F, Murphy JM et al. Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 2007; 149: 353-363.
    • (2007) Clin Exp Immunol , vol.149 , pp. 353-363
    • Ryan, J.M.1    Barry, F.2    Murphy, J.M.3
  • 25
    • 3342967455 scopus 로고    scopus 로고
    • Prostaglandin E2 affects proliferation and collagen synthesis by human patellar tendon fibroblasts
    • Cilli F, KhanM,Fu F et al. Prostaglandin E2 affects proliferation and collagen synthesis by human patellar tendon fibroblasts. Clin J Sport Med 2004; 14: 232-236.
    • (2004) Clin J Sport Med , vol.14 , pp. 232-236
    • Cilli, F.1    Khan, M.2    Fu, F.3
  • 26
    • 0036882114 scopus 로고    scopus 로고
    • Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    • Lama V, Moore BB, Christensen P et al. Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent. Am J Respir Cell Mol Biol 2002; 27: 752-758.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 752-758
    • Lama, V.1    Moore, B.B.2    Christensen, P.3
  • 27
    • 0037309390 scopus 로고    scopus 로고
    • Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2
    • Moore BB, Peters-GoldenM, Christensen PJ et al. Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2. Am J Physiol Lung Cell Mol Physiol 2003; 284: L342-L349.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284 , pp. L342-L349
    • Moore, B.B.1    Peters-Golden, M.2    Christensen, P.J.3
  • 28
    • 34249662219 scopus 로고    scopus 로고
    • IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells
    • English K, Barry FP, Field-Corbett CP et al. IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells. Immunol Lett 2007; 110: 91-100.
    • (2007) Immunol Lett , vol.110 , pp. 91-100
    • English, K.1    Barry, F.P.2    Field-Corbett, C.P.3
  • 29
    • 0035014034 scopus 로고    scopus 로고
    • Regulation of alpha-smooth muscle actin gene expression in myofibroblast differentiation fromrat lung fibroblasts
    • Roy SG, Nozaki Y, Phan SH. Regulation of alpha-smooth muscle actin gene expression in myofibroblast differentiation fromrat lung fibroblasts. Int J Biochem Cell Biol 2001; 33: 723-734.
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 723-734
    • Roy, S.G.1    Nozaki, Y.2    Phan, S.H.3
  • 30
    • 0033168928 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines
    • Henkels KM, Turchi JJ. Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. Cancer Res 1999; 59: 3077-3083.
    • (1999) Cancer Res , vol.59 , pp. 3077-3083
    • Henkels, K.M.1    Turchi, J.J.2
  • 31
    • 0035010796 scopus 로고    scopus 로고
    • The dynamic in vivo distribution of bone marrowderived mesenchymal stem cells after infusion
    • Gao J, Dennis JE, Muzic RF et al. The dynamic in vivo distribution of bone marrowderived mesenchymal stem cells after infusion. Cells Tissues Organs 2001; 169: 12-20.
    • (2001) Cells Tissues Organs , vol.169 , pp. 12-20
    • Gao, J.1    Dennis, J.E.2    Muzic, R.F.3
  • 33
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair-current views
    • Phinney DG, Prockop DJ. Concise review: Mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007; 25: 2896-2902.
    • (2007) Stem Cells , vol.25 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 34
    • 30944455284 scopus 로고    scopus 로고
    • Kidney tubular epitheliumis restored without replacement with bone marrow-derived cells during repair after ischemic injury
    • Duffield JS, Bonventre JV. Kidney tubular epitheliumis restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int 2005; 68: 1956-1961.
    • (2005) Kidney Int , vol.68 , pp. 1956-1961
    • Duffield, J.S.1    Bonventre, J.V.2
  • 35
    • 84911494643 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Role in tissue repair, drug discovery and immune modulation
    • English K, Mahon BP, Wood KJ. Mesenchymal stromal cells: Role in tissue repair, drug discovery and immune modulation. Curr Drug Deliv 2014; 11: 561-571.
    • (2014) Curr Drug Deliv , vol.11 , pp. 561-571
    • English, K.1    Mahon, B.P.2    Wood, K.J.3
  • 36
    • 70449716971 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce dermal fibroblast responses to injury
    • Smith AN, Willis E, Chan VT et al. Mesenchymal stem cells induce dermal fibroblast responses to injury. Exp Cell Res 2010; 316: 48-54.
    • (2010) Exp Cell Res , vol.316 , pp. 48-54
    • Smith, A.N.1    Willis, E.2    Chan, V.T.3
  • 37
    • 84933531432 scopus 로고    scopus 로고
    • Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis
    • Lan YW, Choo KB, Chen CM et al. Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis. Stem Cell Res Ther 2015; 6: 97.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 97
    • Lan, Y.W.1    Choo, K.B.2    Chen, C.M.3
  • 38
    • 84872772689 scopus 로고    scopus 로고
    • Mesenchymal stemcells promote alveolar epithelial cell woundrepair invitro throughdistinctmigratory and paracrine mechanisms
    • Akram KM, Samad S, Spiteri MA et al. Mesenchymal stemcells promote alveolar epithelial cell woundrepair invitro throughdistinctmigratory and paracrine mechanisms. Respir Res 2013; 14: 9.
    • (2013) Respir Res , vol.14 , pp. 9
    • Akram, K.M.1    Samad, S.2    Spiteri, M.A.3
  • 39
    • 79959957498 scopus 로고    scopus 로고
    • Enhancement of wound healing by human multipotent stromal cell conditioned medium: The paracrine factors and p38 MAPK activation
    • Yew TL, Hung YT, Li HY et al. Enhancement of wound healing by human multipotent stromal cell conditioned medium: The paracrine factors and p38 MAPK activation. Cell Transplant 2011; 20: 693-706.
    • (2011) Cell Transplant , vol.20 , pp. 693-706
    • Yew, T.L.1    Hung, Y.T.2    Li, H.Y.3
  • 40
    • 84953863204 scopus 로고    scopus 로고
    • TNF-a and IL-1b-activated humanmesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor
    • Broekman W, Amatngalim GD, de Mooij-Eijk Y et al. TNF-a and IL-1b-activated humanmesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor. Respir Res 2016; 17: 3.
    • (2016) Respir Res , vol.17 , pp. 3
    • Broekman, W.1    Amatngalim, G.D.2    de Mooij-Eijk, Y.3
  • 41
    • 84921327929 scopus 로고    scopus 로고
    • Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis
    • Shen Q,Chen B, Xiao Z et al. Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep 2015; 11: 2831-2837.
    • (2015) Mol Med Rep , vol.11 , pp. 2831-2837
    • Shen, Q.1    Chen, B.2    Xiao, Z.3
  • 42
    • 0033093274 scopus 로고    scopus 로고
    • Prostaglandin-E2 counteracts interleukin-1betastimulatedupregulationofplatelet- derivedgrowth factor alpha-receptor on rat pulmonary myofibroblasts
    • Boyle JE, Lindroos PM, Rice AB et al. Prostaglandin-E2 counteracts interleukin-1betastimulatedupregulationofplatelet- derivedgrowth factor alpha-receptor on rat pulmonary myofibroblasts. AmJ Respir CellMol Biol 1999; 20: 433-440.
    • (1999) AmJ Respir CellMol Biol , vol.20 , pp. 433-440
    • Boyle, J.E.1    Lindroos, P.M.2    Rice, A.B.3
  • 43
    • 0034802721 scopus 로고    scopus 로고
    • Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro
    • PanT,MasonRJ,Westcott JYet al.Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro.AmJRespirCellMol Biol 2001; 25: 353-361.
    • (2001) AmJRespirCellMol Biol , vol.25 , pp. 353-361
    • Pan, T.1    Mason, R.J.2    Westcott, J.Y.3
  • 44
    • 84902682708 scopus 로고    scopus 로고
    • Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury
    • Shyamsundar M, McAuley DF, Ingram RJ et al. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med 2014; 189: 1520-1529.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 1520-1529
    • Shyamsundar, M.1    McAuley, D.F.2    Ingram, R.J.3
  • 45
    • 0033923224 scopus 로고    scopus 로고
    • Involvement of the epidermal growth factor receptor in epithelial repair in asthma
    • PuddicombeSM,Polosa R, RichterAet al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000; 14: 1362-1374.
    • (2000) FASEB J , vol.14 , pp. 1362-1374
    • Puddicombe, S.M.1    Polosa, R.2    Richter, A.3
  • 46
    • 0034791099 scopus 로고    scopus 로고
    • VEGF induces airway epithelial cell proliferation in human fetal lung in vitro
    • Brown KR, England KM, Goss KL et al. VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1001-L1010.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L1001-L1010
    • Brown, K.R.1    England, K.M.2    Goss, K.L.3
  • 47
    • 84872522183 scopus 로고    scopus 로고
    • Therapeutic effects of human mesenchymal stem cells in ex vivohumanlungs injured with live bacteria
    • Lee JW, Krasnodembskaya A, McKenna DH et al. Therapeutic effects of human mesenchymal stem cells in ex vivohumanlungs injured with live bacteria. Am J Respir Crit Care Med 2013; 187: 751-760.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 751-760
    • Lee, J.W.1    Krasnodembskaya, A.2    McKenna, D.H.3
  • 48
    • 84861868459 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
    • Curley GF, Hayes M, Ansari B et al. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax 2012; 67: 496-501.
    • (2012) Thorax , vol.67 , pp. 496-501
    • Curley, G.F.1    Hayes, M.2    Ansari, B.3
  • 49
    • 84872706724 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors
    • Guan XJ, Song L,Han FF et al.Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors. J Cell Biochem 2013; 114: 323-335.
    • (2013) J Cell Biochem , vol.114 , pp. 323-335
    • Guan, X.J.1    Song, L.2    Han, F.F.3
  • 50
    • 33847040423 scopus 로고    scopus 로고
    • Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis
    • Gazdhar A, Fachinger P, van Leer C et al. Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2007; 292: L529-L536.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L529-L536
    • Gazdhar, A.1    Fachinger, P.2    van Leer, C.3
  • 51
    • 20844447573 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis
    • Watanabe M, Ebina M, Orson FM et al. Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. Mol Ther 2005; 12: 58-67.
    • (2005) Mol Ther , vol.12 , pp. 58-67
    • Watanabe, M.1    Ebina, M.2    Orson, F.M.3
  • 52
    • 67650531456 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms
    • Weil BR, Markel TA, Herrmann JL et al. Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms. Surgery 2009; 146: 190-197.
    • (2009) Surgery , vol.146 , pp. 190-197
    • Weil, B.R.1    Markel, T.A.2    Herrmann, J.L.3
  • 54
    • 39149103740 scopus 로고    scopus 로고
    • The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    • Moeller A, Ask K, Warburton D et al. The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 2008; 40: 362-382.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 362-382
    • Moeller, A.1    Ask, K.2    Warburton, D.3
  • 55
    • 84930003294 scopus 로고    scopus 로고
    • The antifibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2
    • Dong LH, Jiang YY, Liu YJ et al. The antifibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2. Sci Rep 2015; 5: 8713.
    • (2015) Sci Rep , vol.5 , pp. 8713
    • Dong, L.H.1    Jiang, Y.Y.2    Liu, Y.J.3
  • 56
    • 84901666413 scopus 로고    scopus 로고
    • Histolgical and immunohistochemical study on the effect of stem cell therapy on bleomycin induced pulmonary fibrosis in albino rat
    • Sabry MM, Elkalawy SA, Abo-Elnour RK et al. Histolgical and immunohistochemical study on the effect of stem cell therapy on bleomycin induced pulmonary fibrosis in albino rat. Int J Stem Cells 2014; 7: 33-42.
    • (2014) Int J Stem Cells , vol.7 , pp. 33-42
    • Sabry, M.M.1    Elkalawy, S.A.2    Abo-Elnour, R.K.3
  • 57
    • 67649910145 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury
    • Moodley Y, Atienza D, Manuelpillai U et al. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol 2009; 175: 303-313.
    • (2009) Am J Pathol , vol.175 , pp. 303-313
    • Moodley, Y.1    Atienza, D.2    Manuelpillai, U.3
  • 58
    • 84924030742 scopus 로고    scopus 로고
    • Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1
    • Ono M, Ohkouchi S, Kanehira M et al. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1. Mol Ther 2015; 23: 549-560.
    • (2015) Mol Ther , vol.23 , pp. 549-560
    • Ono, M.1    Ohkouchi, S.2    Kanehira, M.3
  • 59
    • 84864763371 scopus 로고    scopus 로고
    • Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction
    • Lee YJ, Moon C, Lee SH et al. Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction. Eur Respir J 2012; 40: 424-435.
    • (2012) Eur Respir J , vol.40 , pp. 424-435
    • Lee, Y.J.1    Moon, C.2    Lee, S.H.3
  • 60
    • 84887001008 scopus 로고    scopus 로고
    • Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis
    • Yoon YS, Lee YJ, Choi JY et al. Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis. J Leukoc Biol 2013; 94: 1037-1049.
    • (2013) J Leukoc Biol , vol.94 , pp. 1037-1049
    • Yoon, Y.S.1    Lee, Y.J.2    Choi, J.Y.3
  • 61
    • 84890983425 scopus 로고    scopus 로고
    • Conditioned medium from amniotic membranederived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured micespecificity of the effects and insights into possible mechanisms
    • Cargnoni A, Piccinelli EC, Ressel L et al. Conditioned medium from amniotic membranederived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured micespecificity of the effects and insights into possible mechanisms. Cytotherapy 2014; 16: 17-32.
    • (2014) Cytotherapy , vol.16 , pp. 17-32
    • Cargnoni, A.1    Piccinelli, E.C.2    Ressel, L.3
  • 62
    • 84886455453 scopus 로고    scopus 로고
    • Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels
    • Bustos ML, Huleihel L, Meyer EM et al. Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels. Stem Cells Transl Med 2013; 2: 884-895.
    • (2013) Stem Cells Transl Med , vol.2 , pp. 884-895
    • Bustos, M.L.1    Huleihel, L.2    Meyer, E.M.3
  • 63
    • 84927755768 scopus 로고    scopus 로고
    • The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor
    • Gazdhar A, Grad I,Tamò L et al. The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor. Stem Cell Res Ther 2014; 5: 123.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 123
    • Gazdhar, A.1    Grad, I.2    Tamò, L.3
  • 64
    • 84879231415 scopus 로고    scopus 로고
    • HGF expressing stem cells in usual interstitial pneumonia originate from the bone marrow and are antifibrotic
    • Gazdhar A, Susuri N, Hostettler K et al. HGF expressing stem cells in usual interstitial pneumonia originate from the bone marrow and are antifibrotic. PLoS One 2013; 8: e65453.
    • (2013) PLoS One , vol.8 , pp. 65453
    • Gazdhar, A.1    Susuri, N.2    Hostettler, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.