Histolgical AND immunohistochemical study on the effect of stem cell therapy on bleomycin induced pulmonary fibrosis in albino rat

International Journal of Stem Cells

Volumn 7, Issue 1, 2014, Pages 33-42

  Sabry, Marwa Mohammed ^a   Elkalawy, Seham Abd Elhamed ^a   Abo Elnour, Rahma Kamal El Din ^a   Abd El Maksod, Dalia Fathy ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Bleomycin; BMSCs; Lung fibrosis; PCNA; PKH26; SMA;

Indexed keywords

EID: 84901666413     PISSN: 20053606     EISSN: 20055447     Source Type: Journal    
DOI: 10.15283/ijsc.2014.7.1.33     Document Type: Article

References (30)

1. Keeley EC, Mehrad B, Strieter RM. Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis. Int J Biochem Cell Biol 2010;42:535-542
2. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Müller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schünemann HJ; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011;183:788-824
3. Jindal SK. Interstitial lung disease. In: Jindal SK, editor. Textbook of Pulmonary and Critical Care Medicine. 1st ed. New Delhi; St. Louis: JP Medical Ltd; 2011. 1174-1188
4. Bugaut H, Bruchard M, Berger H, Derangère V, Odoul L, Euvrard R, Ladoire S, Chalmin F, Végran F, Rébé C, Apetoh L, Ghiringhelli F, Mignot G. Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells. PLoS One 2013;8:e65181
5. Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X, Wang J. Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur J Pharmacol 2010;627:304-312
6. Kakugawa T, Mukae H, Hayashi T, Ishii H, Abe K, Fujii T, Oku H, Miyazaki M, Kadota J, Kohno S. Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis. Eur Respir J 2004;24:57-65
7. Hinz B. Regenerative Medicine and Biomaterials for the Repair of Connective Tissues. 2010. p39-82.
8. Zhao R, Du L, Gunst SJ. Contractile and mechanical stimuli regulate cofilin phosphorylation (Cofilin-P) in tracheal smooth muscle (TSM) tissues. The FASEB Journal 2006; 20:A1241
9. Pilling D, Tucker NM, Gomer RH. Aggregated IgG inhibits the differentiation of human fibrocytes. J Leukoc Biol 2006;79:1242-1251
10. Zdunek M, Korobowicz E. Expression of PCNA in non-small cell lung cancer before and after treatment with cisplatin and vepeside. Pol J Pathol 2000;51:77-81
11. Scovassi AI, Prosperi E. Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA. Methods Mol Biol 2006;314:457-475
12. Fukumoto J, Harada C, Kawaguchi T, Suetsugu S, Maeyama T, Inoshima I, Hamada N, Kuwano K, Nakanishi Y. Amphiregulin attenuates bleomycin-induced pneumopathy in mice. Am J Physiol Lung Cell Mol Physiol 2010;298:L131-L138
13. Tzouvelekis A, Antoniadis A, Bouros D. Stem cell therapy in pulmonary fibrosis. Curr Opin Pulm Med 2011; 17:368-373
14. Gimble JM, Guilak F, Bunnell BA. Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther 2010;1:19
15. Rodman DM. Proof-of-concept trials for lung stem cell therapy. Proc Am Thorac Soc 2008;5:731-735
16. Paget GE. And Barnes JM. Toxicty test In: Laurnce DR, Bacharach AL, editors. Evaluation of drug activities: pharmacometrics. London: Academic press; 1964. 135
17. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003;100:8407-8411
18. Kiernan JA. Histological and histochemical methods: theory and practice. 3rd ed. London, New York & New Delhi: Arnold Publisher; 2001. 111-162
19. Bancroft JD, Gamble M. Connective tissue stains. In: Bancroft JD, Gamble M. Theory and practice of histological techniques. 6th ed. Edinburgh, London, Oxford, New York, Philadelphia, St Louis, Sydney, Toronto: Elsevier Health Sciences, Churchill Livingstone; 2008. 150
20. Bancroft JD, Cook HC. Immunocytochemistry. In: Bancroft JD, Cook HC. Manual of histological techniques and their diagnostic applications. 2nd ed. London, Madrid, Melbourne, New York, Tokyo: Churchill Livingstone, Edinburgh; 1994. 263-325
21. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 2004;13:436-448
22. Rochefort GY, Vaudin P, Bonnet N, Pages JC, Domenech J, Charbord P, Eder V. Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies? Respir Res 2005;6:125
23. Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res 2010;19:237-270
24. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003;112: 1776-1784
25. Anversa P, Kajstura J, Leri A, Loscalzo J. Tissue-specific adult stem cells in the human lung. Nat Med 2011;17: 1038-1039
26. Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003;3:921-930
27. Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis. PLoS One 2013;8:e63798
28. Porada CD, Zanjani ED, Almeida-Porad G. Adult mesenchymal stem cells: a pluripotent population with multiple applications. Curr Stem Cell Res Ther 2006;1:365-369
29. Fang X, Neyrinck AP, Matthay MA, Lee JW. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem 2010;285:26211-26222
30. Cui A, Dai HP, Dai JW, Pang BS, Niu SJ, Lü YP, Wang C. Effects of bone marrow mesenchymal stem cells on bleomycin induced pulmonary fibrosis in rats. Zhonghua Jie He He Hu Xi Za Zhi 2007;30:677-682