Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors

Journal of Cellular Biochemistry

Volumn 114, Issue 2, 2013, Pages 323-335

  Guan, Xiao Jun ^a   Song, Lin ^a   Han, Feng Feng ^a   Cui, Zhi Lei ^a   Chen, Xi ^a   Guo, Xue Jun ^a   Xu, Wei Guo ^a  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Chronic obstructive pulmonary disease; Emphysema; Mesenchymal stem cells; Pulmonary function

Indexed keywords

CIGARETTE SMOKE; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 1BETA; MACROPHAGE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEINASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; EMPHYSEMA; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG FUNCTION; LUNG INJURY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RESPIRATORY TRACT INFLAMMATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ANIMALS; DISEASE MODELS, ANIMAL; EMPHYSEMA; GENE EXPRESSION REGULATION; HUMANS; LUNG INJURY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PNEUMONIA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SMOKING; TOBACCO PRODUCTS; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 84872706724     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24377     Document Type: Article

References (46)

1. Aggarwal S, Pittenger MF. 2005. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822.
2. Barnes PJ. 2008. Emerging pharmacotherapies for COPD. Chest 134:1278-1286.
3. Barnes PJ, Shapiro SD, Pauwels RA. 2003. Chronic obstructive pulmonary disease: Molecular and cellular mechanisms. Eur Respir J 22:672-688.
4. Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, Jensen RL, Marks GB, Gulsvik A, Nizankowska-Mogilnicka E. 2007. International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study. Lancet 370:741-750.
5. Chen L, Tredget EE, Wu PY, Wu Y. 2008. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 3:e1886.
6. Chen Y, Hanaoka M, Chen P, Droma Y, Voelkel NF, Kubo K. 2009. Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. Am J Physiol Lung Cell Mol Physiol 296:L648-L656.
7. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A. 2006. Human mesenchymal stem cells modulate B-cell functions. Blood 107:367-372.
8. Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR. 2008. Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. Am J Physiol Cell Physiol 294:C675-C682.
9. D'Agostino B, Sullo N, Siniscalco D, De Angelis A, Rossi F. 2010. Mesenchymal stem cell therapy for the treatment of chronic obstructive pulmonary disease. Expert Opin Biol Ther 10:681-687.
10. de Boer WI, Yao H, Rahman I. 2007. Future therapeutic treatment of COPD: Struggle between oxidants and cytokines. Int J Chron Obstruct Pulmon Dis 2:205-228.
11. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. 2007. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179:1855-1863.
12. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A. 2005. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 7:393-395.
13. Iyer SS, Co C, Rojas M. 2009. Mesenchymal stem cells and inflammatory lung diseases. Panminerva Med 51:5-16.
14. Kanazawa H. 2007. Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Med Sci Monit 13:RA189-RA195.
15. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. 2000. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 106:1311-1319.
16. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. 2001. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 163:737-744.
17. Katsha AM, Ohkouchi S, Xin H, Kanehira M, Sun R, Nukiwa T, Saijo Y. 2011. Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model. Mol Ther 19:196-203.
18. Kermani AJ, Fathi F, Mowla SJ. 2008. Characterization and genetic manipulation of human umbilical cord vein mesenchymal stem cells: Potential application in cell-based gene therapy. Rejuvenation Res 11:379-386.
19. Krampera M, Pasini A, Pizzolo G, Cosmi L, Romagnani S, Annunziato F. 2006. Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol 6:435-441.
20. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, Dini G, Egeler RM, Bacigalupo A, Fibbe W, Ringden O. 2008. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 371:1579-1586.
21. Liu Q, Xu WG, Luo Y, Han FF, Yao XH, Yang TY, Zhang Y, Pi WF, Guo XJ. 2011. Cigarette smoke-induced skeletal muscle atrophy is associated with up-regulation of USP-19 via p38 and ERK MAPKs. J Cell Biochem 112:2307-2316.
22. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. 2003. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 422:169-173.
23. Morty RE, Konigshoff M, Eickelberg O. 2009. Transforming growth factor-beta signaling across ages: From distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 6:607-613.
24. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. 2003. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 100:8407-8411.
25. Park JW, Ryter SW, Choi AM. 2007. Functional significance of apoptosis in chronic obstructive pulmonary disease. COPD 4:347-353.
26. Plataki M, Tzortzaki E, Rytila P, Demosthenes M, Koutsopoulos A, Siafakas NM. 2006. Apoptotic mechanisms in the pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis 1:161-171.
27. Robbesom AA, Versteeg EM, Veerkamp JH, van Krieken JH, Bulten HJ, Smits HT, Willems LN, van Herwaarden CL, Dekhuijzen PN, van Kuppevelt TH. 2003. Morphological quantification of emphysema in small human lung specimens: Comparison of methods and relation with clinical data. Mod Pathol 16:1-7.
28. Roberts AB. 2003. Medicine: Smoke signals for lung disease. Nature 422: 130-131.
29. Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL. 2005. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33:145-152.
30. Salem HK, Thiemermann C. 2003. Mesenchymal stromal cells: Current understanding and clinical status. Stem Cells 28:585-596.
31. Sethi JM, Rochester CL. 2000. Smoking and chronic obstructive pulmonary disease. Clin Chest Med 21:67-86; viii.
32. Shapiro SD. 2007. Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. Eur Respir J 29:375-378.
33. Song L, Xu JF, Qu JM, Sai Y, Chen CM, Yu L, Li DC, Guo XJ. 2012. A therapeutic role for mesenchymal stem cells in acute lung injury independent of hypoxia-induced mitogenic factor. J Cell Mol Med 16:376-385.
34. Stockley RA, Mannino D, Barnes PJ. 2009. Burden and pathogenesis of chronic obstructive pulmonary disease. Proc Am Thorac Soc 6:524-526.
35. Sueblinvong V, Weiss DJ. 2009. Cell therapy approaches for lung diseases: Current status. Curr Opin Pharmacol 9:268-273.
36. Tuder RM, Petrache I, Elias JA, Voelkel NF, Henson PM. 2003. Apoptosis and emphysema: The missing link. Am J Respir Cell Mol Biol 28:551-554.
37. Tuder RM, Yoshida T, Arap W, Pasqualini R, Petrache I. 2006. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: An evolutionary perspective. Proc Am Thorac Soc 3:503-510.
38. Uccelli A, Moretta L, Pistoia V. 2006. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 36:2566-2573.
39. Uccelli A, Pistoia V, Moretta L. 2007. Mesenchymal stem cells: A new strategy for immunosuppression? Trends Immunol 28:219-226.
40. Vanoirbeek JA, Rinaldi M, De Vooght V, Haenen S, Bobic S, Gayan-Ramirez G, Hoet PH, Verbeken E, Decramer M, Nemery B, Janssens W. 2009. Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. Am J Respir Cell Mol Biol 42:96-104.
41. Voelkel NF, Vandivier RW, Tuder RM. 2006. Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 290:L209- L221.
42. Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M. 2007. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 293:L131-L141.
43. Yao H, de Boer WI, Rahman I. 2008. Targeting lung inflammation: Novel therapies for the treatment of COPD. Curr Respir Med Rev 4:57-68.
44. Yoshida T, Tuder RM. 2007. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev 87:1047-1082.
45. Zandvoort A, Postma DS, Jonker MR, Noordhoek JA, Vos JT, van der Geld YM, Timens W. 2006. Altered expression of the Smad signalling pathway: Implications for COPD pathogenesis. Eur Respir J 28:533-541.
46. Zhen G, Xue Z, Zhao J, Gu N, Tang Z, Xu Y, Zhang Z. 2010. Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells. Cytotherapy 12:605-614.