Assay establishment and validation of a high-throughput screening platform for three-dimensional patient-derived colon cancer organoid cultures

Journal of Biomolecular Screening

Volumn 21, Issue 9, 2016, Pages 931-941

  Boehnke, Karsten ^a   Iversen, Philip W ^b   Schumacher, Dirk ^c,d   Lallena, María José ^a   Haro, Rubén ^a   Amat, Joaquín ^a   Haybaeck, Johannes ^e   Liebs, Sandra ^c,d   Lange, Martin ^f   Schäfer, Reinhold ^c,d   Regenbrecht, Christian R A ^c,g   Reinhard, Christoph ^b   Velasco, Juan A ^a  

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f BAYER PHARMA AG   (Germany)

^g EPO GmbH   (Germany)

Author keywords

assay validation; cell based assays; oncology; patient derived organoid culture

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER TISSUE; COLON CARCINOMA; CONTROLLED STUDY; CYTOPLASM; EXTRACELLULAR MATRIX; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; METASTASIS; MICROSCOPY; PRIORITY JOURNAL; CELL CULTURE TECHNIQUE; COLON TUMOR; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; MULTICELLULAR SPHEROID; ORGANOID; PATHOLOGY; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ORGANOIDS; SPHEROIDS, CELLULAR;

EID: 84988517367     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057116650965     Document Type: Article

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