-
2
-
-
0027294719
-
Pancreatitis and the risk of pancreatic cancer
-
International Pancreatitis Study Group
-
Lowenfels AB, Maisonneuve P, Cavallini G, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993;328:1433-7.
-
(1993)
N Engl J Med
, vol.328
, pp. 1433-1437
-
-
Lowenfels, A.B.1
Maisonneuve, P.2
Cavallini, G.3
-
3
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
4
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
5
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
Guerra C, Collado M, Navas C, et al. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011;19:728-39.
-
(2011)
Cancer Cell
, vol.19
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
-
6
-
-
84927912038
-
KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound
-
Eshleman JR, Norris AL, Sadakari Y, et al. KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Clin Gastroenterol Hepatol 2015;13:963-9. e4.
-
(2015)
Clin Gastroenterol Hepatol
, vol.13
, pp. 9639e4
-
-
Eshleman, J.R.1
Norris, A.L.2
Sadakari, Y.3
-
7
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra C, Schuhmacher AJ, Cañamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007;11:291-302.
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
Schuhmacher, A.J.2
Cañamero, M.3
-
8
-
-
64049085356
-
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
-
Carrière C, Young AL, Gunn JR, et al. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun 2009;382:561-5.
-
(2009)
Biochem Biophys Res Commun
, vol.382
, pp. 561-565
-
-
Carrière, C.1
Young, A.L.2
Gunn, J.R.3
-
9
-
-
38649140167
-
Notch signaling is required for exocrine regeneration after acute pancreatitis
-
Siveke JT, Lubeseder-Martellato C, Lee M, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology 2008;134:544-55.
-
(2008)
Gastroenterology
, vol.134
, pp. 544-555
-
-
Siveke, J.T.1
Lubeseder-Martellato, C.2
Lee, M.3
-
10
-
-
48549095907
-
Hedgehog signaling is required for effective regeneration of exocrine pancreas
-
Fendrich V, Esni F, Garay MV, et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 2008;135:621-31.
-
(2008)
Gastroenterology
, vol.135
, pp. 621-631
-
-
Fendrich, V.1
Esni, F.2
Garay, M.V.3
-
11
-
-
84055217307
-
Crosstalk between the canonical NF-kB and Notch signaling pathways inhibits PPAR? Expression and promotes pancreatic cancer progression in mice
-
Maniati E, Bossard M, Cook N, et al. Crosstalk between the canonical NF-kB and Notch signaling pathways inhibits Ppar? expression and promotes pancreatic cancer progression in mice. J Clin Invest 2011;121:4685-99.
-
(2011)
J Clin Invest
, vol.121
, pp. 4685-4699
-
-
Maniati, E.1
Bossard, M.2
Cook, N.3
-
12
-
-
76649105065
-
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
-
Morris JP IV, Cano DA, Sekine S, et al. Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest 2010;120:508-20.
-
(2010)
J Clin Invest
, vol.120
, pp. 508-520
-
-
Morris, J.P.I.V.1
Cano, D.A.2
Sekine, S.3
-
13
-
-
84886803482
-
Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia
-
Greer RL, Staley BK, Liou A, et al. Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. Gastroenterology 2013;145:1088-97. e8.
-
(2013)
Gastroenterology
, vol.145
, pp. 108897e8
-
-
Greer, R.L.1
Staley, B.K.2
Liou, A.3
-
14
-
-
0242365486
-
Pancreatic gene expression during the initiation of acute pancreatitis: Identification of EGR-1 as a key regulator
-
Ji B, Chen XQ, Misek DE, et al. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Physiol Genomics 2003;14:59-72.
-
(2003)
Physiol Genomics
, vol.14
, pp. 59-72
-
-
Ji, B.1
Chen, X.Q.2
Misek, D.E.3
-
15
-
-
84858002179
-
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: A comparative study in transgenic mice and human tissues
-
Aichler M, Seiler C, Tost M, et al. Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 2012;226:723-34.
-
(2012)
J Pathol
, vol.226
, pp. 723-734
-
-
Aichler, M.1
Seiler, C.2
Tost, M.3
-
16
-
-
80051546790
-
From tissue turnover to the cell of origin for pancreatic cancer
-
Kong B, Michalski CW, Erkan M, et al. From tissue turnover to the cell of origin for pancreatic cancer. Nat Rev Gastroenterol Hepatol 2011;8:467-72.
-
(2011)
Nat Rev Gastroenterol Hepatol
, vol.8
, pp. 467-472
-
-
Kong, B.1
Michalski, C.W.2
Erkan, M.3
-
17
-
-
33845998896
-
The pancreatic stellate cell: A star on the rise in pancreatic diseases
-
Omary MB, Lugea A, Lowe AW, et al. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest 2007;117:50-9.
-
(2007)
J Clin Invest
, vol.117
, pp. 50-59
-
-
Omary, M.B.1
Lugea, A.2
Lowe, A.W.3
-
18
-
-
80053332023
-
Pancreatic mesenchyme regulates epithelial organogenesis throughout development
-
Landsman L, Nijagal A, Whitchurch TJ, et al. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol 2011;9: e1001143.
-
(2011)
PLoS Biol
, vol.9
, pp. e1001143
-
-
Landsman, L.1
Nijagal, A.2
Whitchurch, T.J.3
-
19
-
-
84864284886
-
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells
-
Direnzo D, Hess DA, Damsz B, et al. Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology 2012;143:469-80.
-
(2012)
Gastroenterology
, vol.143
, pp. 469-480
-
-
Direnzo, D.1
Hess, D.A.2
Damsz, B.3
-
20
-
-
29244448729
-
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
-
Lee AH, Chu GC, Iwakoshi NN, et al. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. Embo J 2005;24:4368-80.
-
(2005)
Embo J
, vol.24
, pp. 4368-4380
-
-
Lee, A.H.1
Chu, G.C.2
Iwakoshi, N.N.3
-
21
-
-
84895442729
-
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
-
von Figura G, Morris JP IV, Wright CV, et al. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut 2014;63:656-64.
-
(2014)
Gut
, vol.63
, pp. 656-664
-
-
Von Figura, G.1
Morris, J.P.I.V.2
Wright, C.V.3
-
22
-
-
84863696751
-
Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1? In acinar cell homeostasis
-
Molero X, Vaquero EC, Flández M, et al. Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1? in acinar cell homeostasis. Gut 2012;61:1187-96.
-
(2012)
Gut
, vol.61
, pp. 1187-1196
-
-
Molero, X.1
Vaquero, E.C.2
Flández, M.3
-
23
-
-
84884285309
-
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice
-
Martinelli P, Cañamero M, del Pozo N, et al. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut 2013;62:1481-8.
-
(2013)
Gut
, vol.62
, pp. 1481-1488
-
-
Martinelli, P.1
Cañamero, M.2
Del Pozo, N.3
-
24
-
-
77953903417
-
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells
-
Masui T, Swift GH, Deering T, et al. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology 2010;139:270-80.
-
(2010)
Gastroenterology
, vol.139
, pp. 270-280
-
-
Masui, T.1
Swift, G.H.2
Deering, T.3
-
25
-
-
15744400264
-
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
-
Jensen JN, Cameron E, Garay MV, et al. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 2005;128:728-41.
-
(2005)
Gastroenterology
, vol.128
, pp. 728-741
-
-
Jensen, J.N.1
Cameron, E.2
Garay, M.V.3
-
26
-
-
84876351067
-
Gene regulatory networks governing pancreas development
-
Arda HE, Benitez CM, Kim SK. Gene regulatory networks governing pancreas development. Dev Cell 2013;25:5-13.
-
(2013)
Dev Cell
, vol.25
, pp. 5-13
-
-
Arda, H.E.1
Benitez, C.M.2
Kim, S.K.3
-
27
-
-
84876125422
-
Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia
-
Shi G, DiRenzo D, Qu C, et al. Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. Oncogene 2013;32:1950-8.
-
(2013)
Oncogene
, vol.32
, pp. 1950-1958
-
-
Shi, G.1
DiRenzo, D.2
Qu, C.3
-
28
-
-
84907485104
-
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
-
Sherman MH, Yu RT, Engle DD, et al. Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 2014;159:80-93.
-
(2014)
Cell
, vol.159
, pp. 80-93
-
-
Sherman, M.H.1
Yu, R.T.2
Engle, D.D.3
-
29
-
-
84963502839
-
Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation
-
Tape CJ, Ling S, Dimitriadi M, et al. Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell 2016;165:910-20.
-
(2016)
Cell
, vol.165
, pp. 910-920
-
-
Tape, C.J.1
Ling, S.2
Dimitriadi, M.3
-
30
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
31
-
-
57749113202
-
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
-
Habbe N, Shi G, Meguid RA, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci USA 2008;105:18913-18.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18913-18918
-
-
Habbe, N.1
Shi, G.2
Meguid, R.A.3
-
32
-
-
18844421090
-
Mosaic analysis with double markers in mice
-
Zong H, Espinosa JS, Su HH, et al. Mosaic analysis with double markers in mice. Cell 2005;121:479-92.
-
(2005)
Cell
, vol.121
, pp. 479-492
-
-
Zong, H.1
Espinosa, J.S.2
Su, H.H.3
-
33
-
-
79960809488
-
Mosaic analysis with double markers reveals tumor cell of origin in glioma
-
Liu C, Sage JC, Miller MR, et al. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 2011;146:209-21.
-
(2011)
Cell
, vol.146
, pp. 209-221
-
-
Liu, C.1
Sage, J.C.2
Miller, M.R.3
-
34
-
-
78449291189
-
Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration
-
Hippenmeyer S, Youn YH, Moon HM, et al. Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron 2010;68:695-709.
-
(2010)
Neuron
, vol.68
, pp. 695-709
-
-
Hippenmeyer, S.1
Youn, Y.H.2
Moon, H.M.3
-
35
-
-
84856762359
-
Optimality in the development of intestinal crypts
-
Itzkovitz S, Blat IC, Jacks T, et al. Optimality in the development of intestinal crypts. Cell 2012;148:608-19.
-
(2012)
Cell
, vol.148
, pp. 608-619
-
-
Itzkovitz, S.1
Blat, I.C.2
Jacks, T.3
|