Downregulation of ERK signaling impairs U2OS osteosarcoma cell migration in collagen matrix by suppressing MMP9 production

Oncology Letters

Volumn 7, Issue 1, 2014, Pages 215-218

  Poudel, Barun ^a   Kim, Do Kuk ^b   Ki, Hyeon Hui ^a   Kwon, Young Bae ^a   Lee, Young Mi ^b   Kim, Dae Ki ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Extracellular signal regulated kinase; Matrix metalloproteinase 9; Osteosarcoma; PD98059; U2OS

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL) CHROMONE; COLLAGEN TYPE 1; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION ASSAY; CELL INVASION; CELL MIGRATION ASSAY; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOSARCOMA; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WOUND HEALING;

EID: 84888409609     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1655     Document Type: Article

References (16)

1. Husmann K, Arlt MJ, Muff R, Langsam B, Bertz J, Born W and Fuchs B: Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model. Biochim Biophys Acta 1832: 347-354, 2013.
2. Khanna C and Hunter K: Modeling metastasis in vivo. Carcinogenesis 26: 513-523, 2004.
3. Sternlicht MD and Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17: 463-516, 2001.
4. Coussens LM, Fingleton B and Matrisian LM: Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295: 2387-2392, 2002.
5. Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2: 161-174, 2002.
6. Cowan RW, Mak IW, Colterjohn N, Singh G and Ghert M: Collagenase expression and activity in the stromal cells from giant cell tumour of bone. Bone 44: 865-871, 2009.
7. Bjørnland K, Flatmark K, Pettersen S, Aaasen AO, Fodstad O and Maelandsmo GM: Matrix metalloproteinases participate in osteosarcoma invasion. J Surg Res 127: 151-156, 2005.
8. Korpi JT, Hagström J, Lehtonen N, Parkkinen J, Sorsa T, Salo T and Laitinen M: Expression of matrix metalloproteinases-2,-8,-13,-26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. Surg Oncol 20: e18-e22, 2011.
9. Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE and Leung HY: MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 22: 1381-1389, 2003.
10. Ramsay AK, McCracken SR, Soofi M, Fleming J, Yu AX, Ahmad I, Morland R, Machesky L, Nixon C, Edwards DR, Nuttall RK, Seywright M, Marquez R, Keller E and Leung HY: ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer 104: 664-672, 2011.
11. Cho HJ, Lee TS, Park JB, Park KK, Choe JY, Sin DI, Park YY, Moon YS, Lee KG, Yeo JH, Han SM, Cho YS, Choi MR, Park NG, Lee YS and Chang YC: Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J Biochem Mol Biol 40: 1069-1076, 2007.
12. Shintani Y, Maeda M, Chaika N, Johnson KR and Wheelock MJ: Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 38: 95-104, 2008.
13. Fallica B, Maffei JS, Villa S, Makin G and Zaman M: Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels. PLoS One 7: e48024, 2012.
14. Liotta LA, Steeg PS and Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327-336, 1991.
15. Tsuchiya Y, Endo Y, Sato H, Okada Y, Mai M, Sasaki T and Seiki M: Expression of type-IV collagenases in human tumor cell lines that can form liver colonies in chick embryos. Int J Cancer 56: 46-51, 1994.
16. Kim SM, Lee H, Park YS, Lee Y and Seo SW: ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. J Orthop Res 30: 1040-1044, 2012.