Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation

Journal of Ethnopharmacology

Volumn 154, Issue 3, 2014, Pages 728-734

  Li, Yuhua ^a,b   Fan, Lei ^b   Sun, Yang ^b   Miao, Xia ^b   Zhang, Feng ^b   Meng, Jin ^c   Han, Jing ^b   Zhang, Dian ^d   Zhang, Rong ^b   Yue, Zhenggang ^b   Mei, Qibing ^b  

^a No 422 Hospital of PLA   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c 309TH HOSPITAL OF PLA   (China)

^d XI'AN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Growth inhibition; Multidrug resistance (MDR); P glycoprotein (P gp); Paris saponin VII

Indexed keywords

CASPASE 3; CASPASE 8; DOXORUBICIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; RHODAMINE 123; SAPONIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; PARIS SAPONIN VII;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MULTIDRUG RESISTANCE; PROTEIN CONTENT; PROTEIN EXPRESSION; TRILLIUM; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ISOLATION AND PURIFICATION; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; P-GLYCOPROTEIN; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRILLIUM; TUMOR CELLS, CULTURED;

EID: 84902513189     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.049     Document Type: Article

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