Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats

NeuroToxicology

Volumn 57, Issue , 2016, Pages 104-111

  Ma, Chunhua ^a   Long, Hongyan ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Betulin; Cognitive decline; HO 1 Nrf 2 NF B; STZ

Indexed keywords

BETULIN; GLUCOSE; HEME OXYGENASE 1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; CYTOKINE; GA BINDING PROTEIN; GABPA PROTEIN, RAT; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HIPPOCAMPUS; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; MALE; MEMORY; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPATIAL LEARNING; TREATMENT DURATION; UPREGULATION; ANIMAL; BLOOD; COMPLICATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; MAZE TEST; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; COGNITIVE DYSFUNCTION; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GLUCOSE TOLERANCE TEST; HEME OXYGENASE-1; HIPPOCAMPUS; MALE; MALONDIALDEHYDE; MAZE LEARNING; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TRITERPENES; UP-REGULATION;

EID: 84988407766     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.09.009     Document Type: Article

References (32)

1. Asimakopoulou, K., Hampson, S.E., Cognitive functioning and self-management in older people with diabetes. Diabetes Spectr. 15:2 (2002), 116–121.
2. Baluchnejadmojarad, T., Roghani, M., Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress. Behav. Brain Res. 224:2 (2011), 305–310.
3. Baune, B.T., Ponath, G., Rothermundt, M., Riess, O., Funke, H., Berger, K., Association between genetic variants of IL-1β, IL-6 and TNF-α cytokines and cognitive performance in the elderly general population of the MEMO-study. Psychoneuroendocrinology 33:1 (2008), 68–76.
4. Chen, T., Ma, Z., Zhu, L., Jiang, W., Wei, T., Zhou, R., Luo, F., Zhang, K., Fu, Q., Ma, C., Yan, T., Suppressing receptor-interacting protein 140: a new sight for salidroside to treat cerebral ischemia. Mol. Neurobiol., 2015 [Epub ahead of print].
5. Chen, T., Mou, Y., Tan, J., Wei, L., Qiao, Y., Wei, T., Xiang, P., Peng, S., Zhang, Y., Huang, Z., Ji, H., The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice. Int. Immunopharmacol. 25:1 (2015), 55–64.
6. Chen, T., Wang, R., Jiang, W., Wang, H., Xu, A., Lu, G., Ren, Y., Xu, Y., Song, Y., Yong, S., Ji, H., Ma, Z., Protective effect of astragaloside IV against paraquat-induced lung injury in mice by suppressing rho signaling. Inflammation 39:1 (2016), 483–492.
7. Doshi, L.S., Brahma, M.K., Sayyed, S.G., Dixit, A.V., Chandak, P.G., Pamidiboina, V., Motiwala, H.F., Sharma, S.D., Nemmani, K.V., Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat. Metab. Clin. Exp. 58:3 (2009), 333–343.
8. Fukui, K., Omoi, N.O., Hayasaka, T., Shinnkai, T., Suzuki, S., Abe, K., Urano, S., Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann. N. Y. Acad. Sci. 959 (2002), 275–284.
9. Guo, M.Y., Li, W.Y., Zhang, Z., Qiu, C., Li, C., Deng, G., Betulin suppresses S. aureus-induced mammary gland inflammatory injury by regulating PPAR-γ in mice. Int. Immunopharmacol. 29:2 (2015), 824–831.
10. Hua, K., Sheng, X., Li, T.T., Wang, L.N., Zhang, Y.H., Huang, Z.J., Ji, H., The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats. Acta Pharmacol. Sin. 36:8 (2015), 917–927.
11. Jiang, Z.Y., Lu, M.C., Xu, L.L., Yang, T.T., Xi, M.Y., Xu, X.L., Guo, X.K., Zhang, X.J., You, Q.D., Sun, H.P., Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. J. Med. Chem. 57:6 (2014), 2736–2745.
12. Jiang, Q., Yi, M., Guo, Q., Wang, C., Wang, H., Meng, S., Liu, C., Fu, Y., Ji, H., Chen, T., Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-kappaB pathway. Int. Immunopharmacol. 29:2 (2015), 370–376.
13. Jiang, W., Luo, F., Lu, Q., Liu, J., Li, P., Wang, X., Fu, Y., Hao, K., Yan, T., Ding, X., The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state. Chem. Biol. Interact. 243 (2016), 127–134.
14. Jin, H.Y., Liu, W.J., Park, J.H., Baek, H.S., Park, T.S., Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. Arch. Med. Res. 40:7 (2009), 536–544.
15. Kodl, C.T., Seaquist, E.R., Cognitive dysfunction and diabetes mellitus. Endocr. Rev. 29:4 (2008), 494–511.
16. Kucukatay, V., Agar, A., Gumuslu, S., Yargicoglu, P., Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: relation to oxidant stress and antioxidant enzymes. Int. J. Neurosci. 117:8 (2007), 1091–1107.
17. Kuhad, A., Bishnoi, M., Tiwari, V., Chopra, K., Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol. Biochem. Behav. 92:2 (2009), 251–259.
18. Lin, Y.C., Cheng, H.Y., Huang, T.H., Huang, H.W., Lee, Y.H., Peng, W.H., Analgesic and anti-inflammatory activities of Torenia concolor Lindley var. formosana Yamazaki and betulin in mice. Am. J. Chin. Med. 37:1 (2009), 97–111.
19. Liu, Y., Qiu, J., Wang, Z., You, W., Wu, L., Ji, C., Chen, G., Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system. J. Neurosurg. 123:4 (2015), 915–923.
20. Liu, X., Mo, Y., Gong, J., Li, Z., Peng, H., Chen, J., Wang, Q., Ke, Z., Xie, J., Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Metab. Brain Dis. 31:2 (2016), 417–423.
21. Loboda, A., Rojczyk-Golebiewska, E., Bednarczyk-Cwynar, B., Lucjusz, Z., Jozkowicz, A., Dulak, J., Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives. Biomol. Ther. 20:6 (2012), 499–505.
22. Ma, C.H., Kang, L.L., Ren, H.M., Zhang, D.M., Kong, L.D., Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-kappaB/NLRP3 inflammasome activation in high fructose-fed rats. J. Ethnopharmacol. 172 (2015), 108–117.
23. Muceniece, R., Saleniece, K., Rumaks, J., Krigere, L., Dzirkale, Z., Mezhapuke, R., Zharkova, O., Klusa, V., Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. Pharmacol. Biochem. Behav. 90:4 (2008), 712–716.
24. Ong, W.Y., Hu, C.Y., Soh, Y.P., Lim, T.M., Pentchev, P.G., Patel, S.C., Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: a light and electron microscopic immunocytochemical study. Neuroscience 97:1 (2000), 143–153.
25. Sahin, K., Tuzcu, M., Orhan, C., Gencoglu, H., Ulas, M., Atalay, M., Sahin, N., Hayirli, A., Komorowski, J.R., The effects of chromium picolinate and chromium histidinate administration on NF-kappaB and Nrf2/HO-1 pathway in the brain of diabetic rats. Biol. Trace Elem. Res. 150:1–3 (2012), 291–296.
26. Satoh, J., Yagihashi, S., Toyota, T., The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy. Exp. Diabetes Res. 4:2 (2003), 65–71.
27. Schmatz, R., Mazzanti, C.M., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., da Rosa, M.M., Rubin, M.A., Schetinger, M.R.C., Morsch, V.M., Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 610:1 (2009), 42–48.
28. Soyal, S.M., Nofziger, C., Dossena, S., Paulmichl, M., Patsch, W., Targeting SREBPs for treatment of the metabolic syndrome. Trends Pharmacol. Sci. 36:6 (2015), 406–416.
29. Sun, L., Halaihel, N., Zhang, W., Rogers, T., Levi, M., Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus. J. Biol. Chem. 277:21 (2002), 18919–18927.
30. Tang, J.J., Li, J.G., Qi, W., Qiu, W.W., Li, P.S., Li, B.L., Song, B.L., Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab. 13:1 (2011), 44–56.
31. van Muiswinkel, F.L., Kuiperij, H.B., The Nrf2-ARE signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders. Curr. Drug Targets CNS Neurol. Disord. 4:3 (2005), 267–281.
32. Zhu, L., Chen, T., Chang, X., Zhou, R., Luo, F., Liu, J., Zhang, K., Wang, Y., Yang, Y., Long, H., Liu, Y., Yan, T., Ma, C., Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-kappaB pathway. Neuropharmacology 103 (2016), 134–142.