Analgesic and anti-inflammatory activities of torenia concolor lindley var. formosana Yamazaki and betulin in mice

American Journal of Chinese Medicine

Volumn 37, Issue 1, 2009, Pages 97-111

  Lin, Ying Chih ^a   Cheng, Hao Yuan ^b   Huang, Tai Hung ^b   Huang, Hsin Wei ^b   Lee, Yi Hsuan ^b   Peng, Wen Huang ^b  

^a JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Analgesia; Anti inflammation; Betulin; MDA; SOD; Torenia concolor Lindley var. formosana T. Yamazaki

Indexed keywords

ACETIC ACID; BETULIN; CARRAGEENAN; FORMALDEHYDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIVER ENZYME; MALONALDEHYDE; METHANOL; NITRIC OXIDE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TORENIA CONCOLOR EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PAW EDEMA; PROTEIN SYNTHESIS INHIBITION; TORENIA CONCOLOR; WRITHING TEST;

EID: 65449151312     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X09006606     Document Type: Article

References (47)

1. Carlberg, I. and B. Mannervik. Glutathione reductase. Meth. Enzymol. 113: 484-499, 1985.
2. Cuzzocrea, S., B. Zingarelli, G. Calapai, F. Nava and A.P. Caputi. Zymosan-activated plasma induces paw edema by nitric oxide and prostaglandin production. Life Sci. 60: 215-220, 1997.
3. Cuzzocrea, S., E. Mazzon, L. Dugo, I. Serraino, A. Ciccolo, T. Centorrino, A. De Sarro and A.P. Caputi. Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J. 15: 1187-1200, 2001.
4. Cuzzocrea, S., G. Costantino, B. Zingarelli, E. Mazzon, A. Micali and A.P. Caputi. The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat. Eur. J. Pharmacol. 372: 187-197, 1999.
5. Dawson, J., A.D. Sedgwick, J.C. Edwards and P. Lees. A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse. Int. J. Tissue React. 13: 171-185, 1991.
6. Deraedt, R., S. Jouquey, F. Delevallee and M. Flahaut. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 61: 17-24, 1980.
7. Di Rosa, M., J.P. Papadimitrion and D.A. Willoughby. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 104: 15-29, 1971.
8. Ding, C.W. Studies on the chemical constituents of the Torenia concolor Lindley. Master thesis of Graduate Institute of Pharmaceutical Chemistry, Taichung, 2002, pp. 26-27.
9. Duarte, I.D., M. Nakamura and S.H. Ferreira. Participation of the sympathetic system in acetic acid-induced writhing in mice. Braz. J. Med. Biol. Res. 21: 341-343, 1988.
10. Dudhgaonkar, S.P., S.K. Tandan, A.S. Bhat, S.H. Jadhav and D. Kumar. Synergistic anti-inflammatory interaction between meloxicam and amino guanidine hydrocholide in carrageenan-induced acute inflammation in rats. Life Sci. 78: 1044-1058, 2006.
11. Facino, R.M., M. Carini and G. Aldini. Antioxidant activity of nimesulide and its main metabolites. Drugs 46: Suppl 1: 15-21, 1993.
12. Flohe, L. and W.A. Gunzler. Glutathione peroxidase. Meth. Enzymol. 105:115-121, 1984.
13. Franzotti, E.M., C.V. Santos, H.M. Rodrigues, R.H. Mourao, M.R. Andrade and A.R. Antoniolli. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72: 273-277, 2000.
14. 15N) nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
15. Gupta, M.B., T.N. Bhalla, G.P. Gupta, C.R. Mitra and K.P. Bhargava. Anti-inflammatory activity of natural products (I) Triterpenoids. Eur. J. Pharmacol. 6: 67-70, 1969.
16. Huang, M.T., C.T. Ho, Z.Y. Wang, T. Ferraro, Y.R. Lou, K. Stauber, W. Ma, C. Georgiadis, J.D. Laskin and A.H. Conney. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 54: 701-708, 1994.
17. Janero, D.R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med. 9: 515-540, 1990.
18. Kan, W.S. Pharmaceutical Botany. National Research Institute of Chinese Medicine, Taipei, 1993, p. 504.
19. Kasama, T., K. Kobayashi, F. Sekine, M. Negishi, H. Ide, T. Takahashi and Y. Niwa. Follow-up study of lipid peroxides, superoxide dismutase and glutathione peroxidase in the synovial membrane, serum and liver of young and old mice with collagen-induced arthritis. Life Sci. 43: 1887-1896, 1988.
20. Khattab, M.M. TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: A key role for superoxide anion. Eur. J. Pharmacol. 548: 167-173, 2006.
21. Koster, R., M. Anderson and E.J. Beer. Acetic acid for analgesic screening. Fed. Proc. 18: 412-416, 1959.
22. Lu, T.C., Y.Z. Ko, H.W. Huang, Y.C. Hung, Y.C. Lin and W.H. Peng. Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. J. Ethnopharmacol. 113: 142-148, 2007.
23. Ma, X.H., Y.C. Zhao, L. Yin, D.W. Han and M.S. Wang. Studies on the preventive and therapeutic effects of ursolic acid on acute hepatic injury in rats. Acta Pharmacol. Sin. 21: 332-335, 1986.
24. Mahato, S.B., S.K. Sarkar and G. Poddar, G. Triterpenoid saponins. Phytochemistry 27: 3037-3067, 1988.
25. Marklund, S.L., P.A. Kling, S. Nilsson and M. Ohmun. Plasma extracellular superoxide dismutase in the acute phase response induced by surgical trauma and inflammatory disorders. Scand. J. Clin. Lab. Invest. 47: 567-570, 1987.
26. Mascolo, N., R. Jain, S.C. Jain and F. Capasso. Ethnopharmacologic investigation of ginger (Zingiber officinale). J. Ethnopharmacol. 27: 129-140, 1989.
27. Misra, H.P. and I. Fridovich. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247: 3170-3175, 1972.
28. Moshage, H., B. Kok and J.R. Huizenga. Nitrite and nitrate determination in plasma: A critical evaluation. Clin. Chem. 41: 892-896, 1995.
29. Mukherjee, P.K., K. Saha, J. Das, M. Pal and B.P. Saha. Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med. 63: 367-369, 1997.
30. Nantel, F., D. Denis, R. Gordon, A. Northey, M. Cirino, K.M. Metters and C.C. Chan. Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br. J. Pharmacol. 128: 853-859, 1999.
31. Paulus, W.J. Cytokines and heart failure. Heart Fail. Monit. 1: 50-56, 2000.
32. Pisha, E., H. Chai, I.S. Lee, T.E. Chagwedera, N.R. Farnsworth, G.A. Cordell, C.W. Beecher, H.H. Fong, A.D. Kinghorn, D.M. Brown, M.C. Wani, M.E. Wall, T.J. Hieken, T.K.D. Gupta and J.M. Pezzuto. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat. Med. 1: 1046-1051, 1995.
33. Reyes, C.P., M.J. Nunez, I.A. Jimenez, J. Busserolles, M.J. Alcaraz and I.L. Bazzocchi. Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2. Bioorg. Med. Chem. 14: 1573-1579, 2006.
34. Robert, L.J. and J.D. Morrow. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Joel, G.H. and E.L. Lee (eds.) Goodman & Gilman's The Pharmacological Basis of Therapeutics. Macmillan, New York, 2006, pp. 694-695.
35. Romero, A., E. Planas, R. Poveda, S. Sanchez, O. Pol and M.M. Puig. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. Eur. J. Pharmacol. 511: 207-217, 2005.
36. Salvemini, D., Z. Wang, D.M. Bourdon, M.K. Stern, M.G. Currie and P.T. Manning. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur. J. Pharmacol. 303: 217-220, 1996.
37. Saraswat, B., P.K.S. Visen, R. Dayal, D.P. Agarwal and G.K. Patnaik. Protective action of ursolic acid against chemical induced hepatotoxicity in rats. Indian J. Pharmacol. 28: 232-239, 1996.
38. Shibata, M., T. Ohkubo, H. Takahashi and R. Inoki. Modified formalin test: Characteristic biphasic pain response. Pain 38: 347-352, 1989.
39. Tatum, V.L., C. Changchit and C.K. Chow. Measurement of malondialdehyde by high performance liquid chromatography with fluorescence detection. Lipids 25: 226-229, 1990.
40. Tjølsen, A., O.G. Berge, S. Hunskaar, J.H. Rosland and K. Hole. The formalin test: An evaluation of the method. Pain 51: 5-17, 1992.
41. Tokuda, H., H. Ohigashi, K. Koshimizu and Y. Ito. Inhibitory effects of ursolic acid and oleanoic acid on skin tumor promotion by 12-O tetradecanoylphorbol-13-acetate. Cancer Lett. 33: 279-285, 1986.
42. Tracey, W.R., M. Nakane, J. Kuk, G. Budzik, V. Klinghofer, R. Harris and G. Carter. The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J. Pharmacol. Exp. Ther. 273: 1295-1299, 1995.
43. Ueno, A., H. Naraba, Y. Ikeda, F. Ushikubi, T. Murata, S. Naramiya and S. Ohishi. Intrinsic prostacyclin contributes to exudation induced by bradikinin or carrageenan: A study on the paw edema induced in ip-receptor-deficient mice. Life Sci. 66: 155-160, 2000.
44. Vinegar, R., W. Schreiber and R. Hugo. Biphasic development of carrageenan oedema in rats. J. Pharmacol. Exp. Ther. 166: 96-103, 1969.
45. Winter, C.A., E.A. Risley and G.W. Nuss. Carragenin-induced edema in hind paw on the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111: 544-547, 1962.
46. Zhang Y, A. Shaffer J. Portanova, K. Seibert and P.C. Isakson. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 283: 1069-1075, 1997.
47. Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16: 109-110, 1983.