Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

Journal of Neurosurgery

Volumn 123, Issue 4, 2015, Pages 915-923

  Liu, Yizhi ^a   Qiu, Jiaoxue ^a   Wang, Zhong ^a   You, Wanchun ^a   Wu, Lingyun ^a   Ji, Chengyuan ^a   Chen, Gang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Dimethylfumarate; Nrf2; Subarachnoid hemorrhage; Vascular disorders

Indexed keywords

FUMARIC ACID DIMETHYL ESTER; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, RAT; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; CHIASMATIC CISTERN; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEARNING DISORDER; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; ANIMAL; BRAIN INJURIES; COGNITION DISORDERS; COMPLICATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; BRAIN INJURIES; COGNITION DISORDERS; DIMETHYL FUMARATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE;

EID: 84953344617     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2014.11.JNS132348     Document Type: Article

References (32)

1. Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, et al: Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20:524-537, 2011
2. Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, et al: Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation 9:163, 2012
3. Ashrafian H, Czibik G, Bellahcene M, Aksentijevi? D, Smith AC, Mitchell SJ, et al: Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 15:361-371, 2012
4. Ayer RE, Zhang JH: Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir Suppl 104:33-41, 2008
5. Chen G, Fang Q, Zhang J, Zhou D, Wang Z: Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res 89:515-523, 2011
6. Chen G, Shi JX, Hang CH, Xie W, Liu J, Liu X: Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci Lett 425:177-182, 2007
7. Dhar R, Diringer M: Statins and anti-inflammatory therapies for subarachnoid hemorrhage. Curr Treat Options Neurol 14:164-174, 2012
8. Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, et al: Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 367:1098-1107, 2012
9. Gold R, Linker RA, Stangel M: Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of action. Clin Immunol 142:44-48, 2012
10. Jeon H, Ai J, Sabri M, Tariq A, Macdonald RL: Learning deficits after experimental subarachnoid hemorrhage in rats. Neuroscience 169:1805-1814, 2010
11. Jin W, Wang H, Yan W, Xu L, Wang X, Zhao X, et al: Disruption of Nrf2 enhances upregulation of nuclear factorkappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm 2008:725174, 2008
12. Jin W, Zhu L, Guan Q, Chen G, Wang QF, Yin HX, et al: Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injury. Ann Clin Lab Sci 38:221-227, 2008
13. Kim DE, Suh YS, Lee MS, Kim KY, Lee JH, Lee HS, et al: Vascular NAD(P)H oxidase triggers delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Stroke 33:2687-2691, 2002
14. Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, et al: Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J 20:2624-2626, 2006
15. Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, et al: Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134:678-692, 2011
16. Lu H, Zhang DM, Chen HL, Lin YX, Hang CH, Yin HX, et al: N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage. J Clin Neurosci 16:684-688, 2009
17. Macdonald RL, Weir BK: Cerebral vasospasm and free radicals. Free Radic Biol Med 16:633-643, 1994
18. Oh CJ, Kim JY, Choi YK, Kim HJ, Jeong JY, Bae KH, et al: Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-b/ Smad signaling. PLoS ONE 7:e45870, 2012
19. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979
20. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169, 1967
21. Rostami Yazdi M, Mrowietz U: Fumaric acid esters. Clin Dermatol 26:522-526, 2008
22. Sabri M, Ai J, Macdonald RL: Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan. Stroke 42:1454-1460, 2011
23. Shih AY, Li P, Murphy TH: A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 25:10321-10335, 2005
24. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT: Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15:404-414, 2008
25. van Gijn J, Kerr RS, Rinkel GJ: Subarachnoid haemorrhage. Lancet 369:306-318, 2007
26. Wang Z, Ma C, Meng CJ, Zhu GQ, Sun XB, Huo L, et al: Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res 53:129-137, 2012
27. Wilms H, Sievers J, Rickert U, Rostami-Yazdi M, Mrowietz U, Lucius R: Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. J Neuroinflammation 7:30, 2010
28. Wollina U: Fumaric acid esters in dermatology. Indian Dermatol Online J 2:111-119, 2011
29. Zhang J, Zhu Y, Zhou D, Wang Z, Chen G: Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway. Cytokine 52:252-257, 2010
30. Zhang LF, Yang J, Hong Z, Yuan GG, Zhou BF, Zhao LC, et al: Proportion of different subtypes of stroke in China. Stroke 34:2091-2096, 2003
31. Zhao J, Kobori N, Aronowski J, Dash PK: Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393:108-112, 2006
32. Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan YW, et al: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke 38:3280-3286, 2007