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Volumn 4, Issue OCT, 2014, Pages

DQB1*06: 02-associated pathogenic anti-myelin autoimmunity in multiple sclerosis-like disease: Potential function of DQB1*06:02 as a disease-predisposing allele

Author keywords

Antigens peptides epitopes; HLA DR15 Tg mice; MS EAE; Neuroimmunology; T cells

Indexed keywords

HLA DQB1 ANTIGEN; MYELIN;

EID: 84987962229     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00280     Document Type: Review
Times cited : (13)

References (51)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol (2005) 23:683-747. doi: 10.1146/annurev.immunol.23.021704.115707
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 0017109389 scopus 로고
    • B-lymphocyte alloantigens associated with multiple sclerosis
    • Compston DA, Batchelor JR, McDonald WI. B-lymphocyte alloantigens associated with multiple sclerosis. Lancet (1976) 2(7998):1261-5. doi:10.1016/S0140-6736(76)92027-4
    • (1976) Lancet , vol.2 , Issue.7998 , pp. 1261-1265
    • Compston, D.A.1    Batchelor, J.R.2    McDonald, W.I.3
  • 3
    • 0025767289 scopus 로고
    • HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation
    • Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens (1991) 38(1):1-15. doi:10.1111/j.1399-0039.1991.tb02029.x
    • (1991) Tissue Antigens , vol.38 , Issue.1 , pp. 1-15
    • Olerup, O.1    Hillert, J.2
  • 5
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
    • Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron (2006) 52(1):61-76. doi:10.1016/j.neuron.2006.09.011
    • (2006) Neuron , vol.52 , Issue.1 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 7
    • 84888231843 scopus 로고    scopus 로고
    • Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
    • Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, et al. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 9(11):e1003926. doi:10.1371/journal.pgen.1003926
    • (2013) PLoS Genet , vol.9 , Issue.11
    • Patsopoulos, N.A.1    Barcellos, L.F.2    Hintzen, R.Q.3    Schaefer, C.4    van Duijn, C.M.5    Noble, J.A.6
  • 8
    • 0028931032 scopus 로고
    • The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4
    • Altmann DM, Douek DC, Frater AJ, Hetherington CM, Inoko H, Elliott JI. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J Exp Med (1995) 181(3):867-75. doi:10.1084/jem.181.3.867
    • (1995) J Exp Med , vol.181 , Issue.3 , pp. 867-875
    • Altmann, D.M.1    Douek, D.C.2    Frater, A.J.3    Hetherington, C.M.4    Inoko, H.5    Elliott, J.I.6
  • 9
    • 4544353193 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice
    • Rich C, Link JM, Zamora A, Jacobsen H, Meza-Romero R, Offner H, et al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol (2004) 34(5):1251-61. doi:10.1002/eji.200324354
    • (2004) Eur J Immunol , vol.34 , Issue.5 , pp. 1251-1261
    • Rich, C.1    Link, J.M.2    Zamora, A.3    Jacobsen, H.4    Meza-Romero, R.5    Offner, H.6
  • 10
    • 70349231091 scopus 로고    scopus 로고
    • HLA-DQB1*0602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice
    • Kaushansky N, Altmann DM, Ascough S, David CS, Lassmann H, Ben-Nun A. HLA-DQB1*0602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice. J Immunol (2009) 183(5):3531-41. doi:10.4049/jimmunol.0900784
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3531-3541
    • Kaushansky, N.1    Altmann, D.M.2    Ascough, S.3    David, C.S.4    Lassmann, H.5    Ben-Nun, A.6
  • 11
    • 84856617592 scopus 로고    scopus 로고
    • DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)
    • Kaushansky N, Altmann DM, David CS, Lassmann H, Ben-Nun A. DQB1*602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). J Neuroinflammation (2012) 9:29-43. doi:10.1186/1742-2094-9-29
    • (2012) J Neuroinflammation , vol.9 , pp. 29-43
    • Kaushansky, N.1    Altmann, D.M.2    David, C.S.3    Lassmann, H.4    Ben-Nun, A.5
  • 12
    • 0026521045 scopus 로고
    • Novel HLA-DR2-related haplotypes in Hong Kong Chinese implicate the DQB1*0602 allele in susceptibility to multiple sclerosis
    • Serjeantson SW, Gao X, Hawkins BR, Higgins DA, Yu YL. Novel HLA-DR2-related haplotypes in Hong Kong Chinese implicate the DQB1*0602 allele in susceptibility to multiple sclerosis. Eur J Immunogenet (1992) 19(1-2):11-9. doi:10.1111/j.1744-313X.1992.tb00043.x
    • (1992) Eur J Immunogenet , vol.19 , Issue.1-2 , pp. 11-19
    • Serjeantson, S.W.1    Gao, X.2    Hawkins, B.R.3    Higgins, D.A.4    Yu, Y.L.5
  • 13
    • 34248158343 scopus 로고    scopus 로고
    • Fernandez y Fernandez O: ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients
    • Alves-Leon SV, Papais-Alvarenga R, Magalhaes M, Alvarenga M, Thuler LC. Fernandez y Fernandez O: ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients. Acta Neurol Scand (2007) 115(5):306-11. doi:10.1111/j.1600-0404.2006.00750.x
    • (2007) Acta Neurol Scand , vol.115 , Issue.5 , pp. 306-311
    • Alves-Leon, S.V.1    Papais-Alvarenga, R.2    Magalhaes, M.3    Alvarenga, M.4    Thuler, L.C.5
  • 14
    • 10444286904 scopus 로고    scopus 로고
    • DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain
    • Fernandez O, Fernandez V, Alonso A, Caballero A, Luque G, Bravo M, et al. DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain. J Neurol (2004) 251(4):440-4. doi:10.1007/s00415-004-0350-2
    • (2004) J Neurol , vol.251 , Issue.4 , pp. 440-444
    • Fernandez, O.1    Fernandez, V.2    Alonso, A.3    Caballero, A.4    Luque, G.5    Bravo, M.6
  • 15
    • 45549092100 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    • Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet (2008) 9(7):516-26. doi:10.1038/nrg2395
    • (2008) Nat Rev Genet , vol.9 , Issue.7 , pp. 516-526
    • Oksenberg, J.R.1    Baranzini, S.E.2    Sawcer, S.3    Hauser, S.L.4
  • 16
    • 79952833259 scopus 로고    scopus 로고
    • Multiple sclerosis genetics
    • McElroy JP, Oksenberg JR. Multiple sclerosis genetics. Neurol Clin (2010) 29(2):219-31. doi:10.1016/j.ncl.2010.12.002
    • (2010) Neurol Clin , vol.29 , Issue.2 , pp. 219-231
    • McElroy, J.P.1    Oksenberg, J.R.2
  • 17
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 476(7359):214-9. doi:10.1038/nature10251
    • (2011) Nature , vol.476 , Issue.7359 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.4    Patsopoulos, N.A.5    Moutsianas, L.6
  • 18
    • 77956262278 scopus 로고    scopus 로고
    • Multiple sclerosis genetics-is the glass half full, or half empty?
    • Oksenberg JR, Baranzini SE. Multiple sclerosis genetics-is the glass half full, or half empty? Nat Rev Neurol (2010) 6(8):429-37. doi:10.1038/nrneurol.2010.91
    • (2010) Nat Rev Neurol , vol.6 , Issue.8 , pp. 429-437
    • Oksenberg, J.R.1    Baranzini, S.E.2
  • 20
    • 66149110388 scopus 로고    scopus 로고
    • Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    • Lincoln MR, Ramagopalan SV, Chao MJ, Herrera BM, Deluca GC, Orton SM, et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A (2009) 106(18):7542-7. doi:10.1073/pnas.0812664106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.18 , pp. 7542-7547
    • Lincoln, M.R.1    Ramagopalan, S.V.2    Chao, M.J.3    Herrera, B.M.4    Deluca, G.C.5    Orton, S.M.6
  • 21
    • 0033862965 scopus 로고    scopus 로고
    • HLA-DR15 is associated with lower age at onset in multiple sclerosis
    • Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J. HLA-DR15 is associated with lower age at onset in multiple sclerosis. Ann Neurol (2000) 48(2):211-9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R
    • (2000) Ann Neurol , vol.48 , Issue.2 , pp. 211-219
    • Masterman, T.1    Ligers, A.2    Olsson, T.3    Andersson, M.4    Olerup, O.5    Hillert, J.6
  • 23
    • 0030918147 scopus 로고    scopus 로고
    • The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer
    • Spurkland A, Celius EG, Knutsen I, Beiske A, Thorsby E, Vartdal F. The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer. Tissue Antigens (1997) 50(1):15-22. doi:10.1111/j.1399-0039.1997.tb02828.x
    • (1997) Tissue Antigens , vol.50 , Issue.1 , pp. 15-22
    • Spurkland, A.1    Celius, E.G.2    Knutsen, I.3    Beiske, A.4    Thorsby, E.5    Vartdal, F.6
  • 24
    • 0344472580 scopus 로고
    • Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein
    • Sakai K, Sinha AA, Mitchell DJ, Zamvil SS, Rothbard JB, McDevitt HO, et al. Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc Natl Acad Sci U S A (1988) 85(22):8608-12. doi:10.1073/pnas.85.22.8608
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.22 , pp. 8608-8612
    • Sakai, K.1    Sinha, A.A.2    Mitchell, D.J.3    Zamvil, S.S.4    Rothbard, J.B.5    McDevitt, H.O.6
  • 25
    • 0025787985 scopus 로고
    • Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice
    • Whitham RH, Jones RE, Hashim GA, Hoy CM, Wang RY, Vandenbark AA, et al. Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice. J Immunol (1991) 147(11):3803-8.
    • (1991) J Immunol , vol.147 , Issue.11 , pp. 3803-3808
    • Whitham, R.H.1    Jones, R.E.2    Hashim, G.A.3    Hoy, C.M.4    Wang, R.Y.5    Vandenbark, A.A.6
  • 26
    • 0028965522 scopus 로고
    • Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes
    • Kerlero de Rosbo N, Mendel I, Ben-Nun A. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur J Immunol (1995) 25(4):985-93. doi:10.1002/eji.1830250419
    • (1995) Eur J Immunol , vol.25 , Issue.4 , pp. 985-993
    • Kerlero de Rosbo, N.1    Mendel, I.2    Ben-Nun, A.3
  • 27
    • 10244219871 scopus 로고    scopus 로고
    • Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice
    • Mendel Kerlero de Rosbo N, Ben-Nun A. Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice. Eur J Immunol (1996) 26(10):2470-9.
    • (1996) Eur J Immunol , vol.26 , Issue.10 , pp. 2470-2479
    • Mendel Kerlero de Rosbo, N.1    Ben-Nun, A.2
  • 28
    • 0029058504 scopus 로고
    • Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis
    • Johns TG, Kerlero de Rosbo N, Menon KK, Abo S, Gonzales MF, Bernard CC. Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. J Immunol (1995) 154(10):5536-41.
    • (1995) J Immunol , vol.154 , Issue.10 , pp. 5536-5541
    • Johns, T.G.1    Kerlero de Rosbo, N.2    Menon, K.K.3    Abo, S.4    Gonzales, M.F.5    Bernard, C.C.6
  • 29
    • 0342844271 scopus 로고    scopus 로고
    • Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T-and B-cell epitopes
    • Kerlero de Rosbo N, Brok HP, Bauer J, Kaye JF, Hart BA, Ben-Nun A. Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T-and B-cell epitopes. J Neuroimmunol (2000) 110(1-2):83-96. doi:10.1016/S0165-5728(00)00306-4
    • (2000) J Neuroimmunol , vol.110 , Issue.1-2 , pp. 83-96
    • Kerlero de Rosbo, N.1    Brok, H.P.2    Bauer, J.3    Kaye, J.F.4    Hart, B.A.5    Ben-Nun, A.6
  • 30
    • 0033621626 scopus 로고    scopus 로고
    • The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)
    • Kaye JF, Kerlero de Rosbo N, Mendel I, Flechter S, Hoffman M, Yust I, et al. The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS). J Neuroimmunol (2000) 102(2):189-98. doi:10.1016/S0165-5728(99)00168-X
    • (2000) J Neuroimmunol , vol.102 , Issue.2 , pp. 189-198
    • Kaye, J.F.1    Kerlero de Rosbo, N.2    Mendel, I.3    Flechter, S.4    Hoffman, M.5    Yust, I.6
  • 31
    • 0032719206 scopus 로고    scopus 로고
    • A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
    • Madsen LS, Andersson EC, Jansson L, Krogsgaard M, Andersen CB, Engberg J, et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet (1999) 23(3):343-7. doi:10.1038/15525
    • (1999) Nat Genet , vol.23 , Issue.3 , pp. 343-347
    • Madsen, L.S.1    Andersson, E.C.2    Jansson, L.3    Krogsgaard, M.4    Andersen, C.B.5    Engberg, J.6
  • 32
    • 0041846811 scopus 로고    scopus 로고
    • A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein
    • Sireci G, Dieli F, Caccamo N, Barera A, Carta P, Di Sano C, et al. A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein. Scand J Immunol (2003) 58(2):188-94. doi:10.1046/j.1365-3083.2003.01296.x
    • (2003) Scand J Immunol , vol.58 , Issue.2 , pp. 188-194
    • Sireci, G.1    Dieli, F.2    Caccamo, N.3    Barera, A.4    Carta, P.5    Di Sano, C.6
  • 33
    • 0033994751 scopus 로고    scopus 로고
    • Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis
    • Das P, Drescher KM, Geluk A, Bradley DS, Rodriguez M, David CS. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Hum Immunol (2000) 61(3):279-89. doi:10.1016/S0198-8859(99)00135-4
    • (2000) Hum Immunol , vol.61 , Issue.3 , pp. 279-289
    • Das, P.1    Drescher, K.M.2    Geluk, A.3    Bradley, D.S.4    Rodriguez, M.5    David, C.S.6
  • 34
    • 15844398106 scopus 로고    scopus 로고
    • HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    • Ito K, Bian HJ, Molina M, Han J, Magram J, Saar E, et al. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med (1996) 183(6):2635-44. doi:10.1084/jem.183.6.2635
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2635-2644
    • Ito, K.1    Bian, H.J.2    Molina, M.3    Han, J.4    Magram, J.5    Saar, E.6
  • 35
    • 0034128717 scopus 로고    scopus 로고
    • Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice
    • Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, et al. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J Clin Invest (2000) 105(7):977-84. doi:10.1172/JCI8407
    • (2000) J Clin Invest , vol.105 , Issue.7 , pp. 977-984
    • Kawamura, K.1    Yamamura, T.2    Yokoyama, K.3    Chui, D.H.4    Fukui, Y.5    Sasazuki, T.6
  • 36
    • 55549104692 scopus 로고    scopus 로고
    • Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
    • Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM, et al. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med (2008) 14(11):1227-35. doi:10.1038/nm.1881
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1227-1235
    • Friese, M.A.1    Jakobsen, K.B.2    Friis, L.3    Etzensperger, R.4    Craner, M.J.5    McMahon, R.M.6
  • 37
    • 0035893011 scopus 로고    scopus 로고
    • T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells
    • Forsthuber TG, Shive CL, Wienhold W, de Graaf K, Spack EG, Sublett R, et al. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J Immunol (2001) 167(12):7119-25. doi:10.4049/jimmunol.167.12.7119
    • (2001) J Immunol , vol.167 , Issue.12 , pp. 7119-7125
    • Forsthuber, T.G.1    Shive, C.L.2    Wienhold, W.3    de Graaf, K.4    Spack, E.G.5    Sublett, R.6
  • 38
    • 0037385749 scopus 로고    scopus 로고
    • HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis
    • Khare M, Rodriguez M, David CS. HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis. Int Immunol (2003) 15(4):535-46. doi:10.1093/intimm/dxg053
    • (2003) Int Immunol , vol.15 , Issue.4 , pp. 535-546
    • Khare, M.1    Rodriguez, M.2    David, C.S.3
  • 39
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions
    • Kerlero de Rosbo N, Hoffman M, Mendel I, Yust I, Kaye J, Bakimer R, et al. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol (1997) 27(11):3059-69. doi:10.1002/eji.1830271144
    • (1997) Eur J Immunol , vol.27 , Issue.11 , pp. 3059-3069
    • Kerlero de Rosbo, N.1    Hoffman, M.2    Mendel, I.3    Yust, I.4    Kaye, J.5    Bakimer, R.6
  • 40
    • 42449144715 scopus 로고    scopus 로고
    • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
    • Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 57(4):1084-92. doi:10.2337/db07-1331
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1084-1092
    • Erlich, H.1    Valdes, A.M.2    Noble, J.3    Carlson, J.A.4    Varney, M.5    Concannon, P.6
  • 41
    • 67449116625 scopus 로고    scopus 로고
    • Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    • Pollinger B, Krishnamoorthy G, Berer K, Lassmann H, Bosl MR, Dunn R, et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med (2009) 206(6):1303-16. doi:10.1084/jem.20090299
    • (2009) J Exp Med , vol.206 , Issue.6 , pp. 1303-1316
    • Pollinger, B.1    Krishnamoorthy, G.2    Berer, K.3    Lassmann, H.4    Bosl, M.R.5    Dunn, R.6
  • 42
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med (2003) 197(9):1073-81. doi:10.1084/jem.20021603
    • (2003) J Exp Med , vol.197 , Issue.9 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 43
    • 27344459905 scopus 로고    scopus 로고
    • HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice
    • Khare M, Mangalam A, Rodriguez M, David CS. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. J Neuroimmunol (2005) 169(1-2):1-12. doi:10.1016/j.jneuroim.2005.07.023
    • (2005) J Neuroimmunol , vol.169 , Issue.1-2 , pp. 1-12
    • Khare, M.1    Mangalam, A.2    Rodriguez, M.3    David, C.S.4
  • 44
    • 65249147878 scopus 로고    scopus 로고
    • HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice
    • Mangalam A, Luckey D, Basal E, Jackson M, Smart M, Rodriguez M, et al. HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J Immunol (2009) 182(8):5131-9. doi:10.4049/jimmunol.0803918
    • (2009) J Immunol , vol.182 , Issue.8 , pp. 5131-5139
    • Mangalam, A.1    Luckey, D.2    Basal, E.3    Jackson, M.4    Smart, M.5    Rodriguez, M.6
  • 45
    • 0028020575 scopus 로고
    • Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin
    • Yamamoto Y, Mizuno R, Nishimura T, Ogawa Y, Yoshikawa H, Fujimura H, et al. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. J Biol Chem (1994) 269(50):31725-30.
    • (1994) J Biol Chem , vol.269 , Issue.50 , pp. 31725-31730
    • Yamamoto, Y.1    Mizuno, R.2    Nishimura, T.3    Ogawa, Y.4    Yoshikawa, H.5    Fujimura, H.6
  • 46
    • 0029009401 scopus 로고
    • Identification of new oligodendrocyte-and myelin-specific genes by a differential screening approach
    • Schaeren-Wiemers N, Schaefer C, Valenzuela DM, Yancopoulos GD, Schwab ME. Identification of new oligodendrocyte-and myelin-specific genes by a differential screening approach. J Neurochem (1995) 65(1):10-22. doi:10.1046/j.1471-4159.1995.65010010.x
    • (1995) J Neurochem , vol.65 , Issue.1 , pp. 10-22
    • Schaeren-Wiemers, N.1    Schaefer, C.2    Valenzuela, D.M.3    Yancopoulos, G.D.4    Schwab, M.E.5
  • 47
    • 3142781394 scopus 로고    scopus 로고
    • The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501
    • de Rosbo NK, Kaye JF, Eisenstein M, Mendel I, Hoeftberger R, Lassmann H, et al. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. J Immunol (2004) 173(2):1426-35. doi:10.4049/jimmunol.173.2.1426
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 1426-1435
    • de Rosbo, N.K.1    Kaye, J.F.2    Eisenstein, M.3    Mendel, I.4    Hoeftberger, R.5    Lassmann, H.6
  • 48
    • 0034650603 scopus 로고    scopus 로고
    • Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis
    • Holz A, Bielekova B, Martin R, Oldstone MB. Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. J Immunol (2000) 164(2):1103-9. doi:10.4049/jimmunol.164.2.1103
    • (2000) J Immunol , vol.164 , Issue.2 , pp. 1103-1109
    • Holz, A.1    Bielekova, B.2    Martin, R.3    Oldstone, M.B.4
  • 49
    • 0030861738 scopus 로고    scopus 로고
    • Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
    • Greer JM, Csurhes PA, Cameron KD, McCombe PA, Good MF, Pender MP. Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain (1997) 120(Pt 8):1447-60. doi:10.1093/brain/120.8.1447
    • (1997) Brain , vol.120 , pp. 1447-1460
    • Greer, J.M.1    Csurhes, P.A.2    Cameron, K.D.3    McCombe, P.A.4    Good, M.F.5    Pender, M.P.6
  • 50
    • 40449089827 scopus 로고    scopus 로고
    • Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells
    • Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med (2008) 14(3):337-42. doi:10.1038/nm1715
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 337-342
    • Stromnes, I.M.1    Cerretti, L.M.2    Liggitt, D.3    Harris, R.A.4    Goverman, J.M.5
  • 51
    • 77957574537 scopus 로고    scopus 로고
    • Celiac disease: how complicated can it get?
    • Tjon JM, van Bergen J, Koning F. Celiac disease: how complicated can it get? Immunogenetics (2010) 62(10):641-51. doi:10.1007/s00251-010-0465-9
    • (2010) Immunogenetics , vol.62 , Issue.10 , pp. 641-651
    • Tjon, J.M.1    van Bergen, J.2    Koning, F.3


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