DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain

Journal of Neurology

Volumn 251, Issue 4, 2004, Pages 440-444

  Fernandez O ^a   Fernandez V ^a   Alonso, A ^a   Caballero, A ^a   Luque, G ^a   Bravo, M ^a   Leon, A ^a   Mayorga, C ^a   Leyva, L ^a   De Ramon E ^a  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

HLA class II alleles; Multiple sclerosis

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DQB1 PROTEIN, HUMAN; HLA-DQB1 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC ANALYSIS; GENOMIC IN SITU HYBRIDIZATION; GENOTYPE; HAPLOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; OLIGONUCLEOTIDE PROBE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SPAIN; STATISTICAL SIGNIFICANCE; ADOLESCENT; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; GENE FREQUENCY; GENETICS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHENOTYPE; RISK; STATISTICAL MODEL;

ADOLESCENT; ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; COHORT STUDIES; CONFIDENCE INTERVALS; FEMALE; GENE FREQUENCY; HLA-DQ ANTIGENS; HUMANS; LOGISTIC MODELS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; ODDS RATIO; PHENOTYPE; SPAIN;

EID: 10444286904     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-004-0350-2     Document Type: Article

References (23)

1. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2000) Multiple sclerosis. N Engl J Med 343:938-952
2. Kalman B, Lublin FD (1999) The genetics of multiple sclerosis. A review. Biomed Pharmacother 53:358-370
3. Oksenberg JR, Barcellos LF (2000) The complex genetic aetiology of multiple sclerosis. J Neurovirol 6:S10-14
4. Hillert J (1994) Human leukocyte antigen studies in multiple sclerosis. Ann Neurol 36:15-17
5. Marrosu MG, Murru MR, Costa G et al. (1998) DRB1. DQA1-DQB1 loci and multiple sclerosis predisposition in Sardinian population. Hum Mol Genet 7:1235-1237
6. Saruhan-Direskeneli G, Esin S, Baykan-Kkurt B et al. (1997) HLA-DR and -DQ associations with multiple sclerosis in Turkey. Hum Immunol 55:59-65
7. Coraddu F, Reyes-Yanez MP, Parra A et al. (1998) HLA associations with multiple sclerosis in the Canary Islands. J Neuroimmunol 87:130-135
8. Sánchez J, Ocón P, de Ramón E et al. (1997) Caucasian Spanish Normal. In Terasaki and Gjertson (eds). HLA. Los Angeles: UCLA Tissue Typing Laboratory 246
9. Fernández O, Luque G, San Román C et al. (1994) The prevalence of multiple sclerosis in the sanitary district of Vélez Malaga, southern Spain. Neurology 44:425-429
10. Riise T, Gróning M, Fernández O et al. (1992) Early prognostic factors for disability in multiple sclerosis, a European multicenter study. Acta Neurol Scand 85:212-218
11. Celius EG, Harbo HF, Egeland T et al. (2000) Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis. J Neurol Sci 178:132-135
12. Masterman T, Ligers A, Olsson T et al. (2000) HLA-DR15 is associated with lower age at onset in multiple sclerosis. Ann Neurol 48:211-219
13. Hensiek AE, Sawcer SJ, Feakes R et al. (2002) HLA-DR15 is associated with female sex and younger age at diagnosis in multiple sclerosis. J Neurol Neurosurg Psychiatry 72:184-187
14. Poser CM, Paty DW, Scheinberg L et al. (1983) New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 13:227-231
15. Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 46:906-911
16. Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis: an expanded disability scale status. Neurology 33:1444-1452
17. Clerici N, Fernández M (1992) Restriction fragment length polymorphism analysis of HLA-DR and DQ linked alleles in multiple sclerosis in Spain. J Neuroimmunol 41:245-248
18. Uría DF, Gutierrez V, Menes BB et al. (1993) HLA class II susceptibility and resistance genes in patients with multiple sclerosis from Northern Spain by DNA-RFLP genotyping. J Neurol Neurosurg Psychiatry 56:722-723
19. Pina MA, Ara JR, Lasierra P et al. (1999) Study of the HLA as a predisposing factor and its possible influence on the outcome of multiple sclerosis in the sanitary district of Calatayud, northern Spain. Neuroepidemiology 18:203-209
20. de la Concha EG, Arroyo R, Crusius JBA et al. (1997) Combined effect of HLA-DRB1Black star1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis. J Neuroimmunol 80:172-178
21. Poser CM (1995) Viking voyages: the origin of multiple sclerosis? An essay in medical history. Acta Neurol Scand 161:11-22
22. Caballero A, Alvés-León S, Papais-Alvarenga R et al. (1999) DQB1Black star0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians. Tissue Antigens 54:524-526
23. Ligers A, Dyment D, Willer C, Sadovnick D, Ebers G, Risch N, Hillert J and the Canadian Collaborative Study Groups (2001) Evidence of linkage with HLA-DR in DRB1Black star15-negative families with multiple sclerosis. Am J Hum Genet 69:900-903