Male Sexual Function and Smoking

Sexual Medicine Reviews

Volumn 4, Issue 4, 2016, Pages 366-375

  Biebel, Mark G ^a   Burnett, Arthur L ^b   Sadeghi Nejad, Hossein ^a,c,d  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Erectile Dysfunction; Penile Erection; Smoking; Smoking Cessation; Tobacco

Indexed keywords

NICOTINE;

AUTONOMIC NEUROPATHY; CASE STUDY; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; HISTOPATHOLOGY; HUMAN; MALE; PASSIVE SMOKING; PENILE BLOOD FLOW; PENIS ERECTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOKING; SMOKING CESSATION; TOBACCO; PENIS;

ERECTILE DYSFUNCTION; HUMANS; MALE; PENILE ERECTION; PENIS; SMOKING;

EID: 84987905143     PISSN: 20500513     EISSN: 20500521     Source Type: Journal    
DOI: 10.1016/j.sxmr.2016.05.001     Document Type: Review

References (83)

1. 1 NIH Consensus Development Panel on Impotence. NIH consensus conference: Impotence. JAMA 270 (1993), 83–90.
2. 2 Saigal, C.S., Wessells, H., Pace, J., et al. Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch Intern Med 166 (2006), 207–212.
3. 3 Selvin, E., Burnett, A.L., Platz, E.A., Prevalence and risk factors for erectile dysfunction in the U.S. Am J Med 120 (2007), 151–157.
4. 4 Johannes, C.B., Araujo, A.B., Feldman, H.A., et al. Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts Male Aging Study. J Urol 163 (2000), 460–463.
5. 5 Goldstein, I., Hatzichristou, D., Epidemiology of impotence. Bennett, A., (eds.) Impotence: Diagnosis and management of erectile dysfunction, 1994, WB Saunders, Philadelphia, 1–17.
6. 6 Kendirci, M., Trost, L., Sikka, S.C., et al. The effect of vascular risk factors on penile vascular status in men with erectile dysfunction. J Urol 178 (2007), 2516–2520.
7. 7 Miner, M., Billups, K.L., Erectile dysfunction and dyslipidemia: Relevance and role of phosphodiesterase type-5 inhibitors and statins. J Sex Med 5 (2008), 1066–1078.
8. 8 Bornman, M.S., du Plessis, D.J., Smoking and vascular impotence: A reason for concern. S Afr Med J 70 (1986), 329–330.
9. 9 Juenemann, K.P., Lue, T.F., Luo, J.A., et al. The effect of cigarette smoking on penile erection. J Urol 138 (1987), 438–441.
10. 10 Mannino, D.M., Klevens, R.M., Flanders, W.D., Cigarette smoking: An independent risk factor for impotence?. Am J Epidemiol 140 (1994), 1003–1008.
11. 11 Polsky, J.Y., Aronson, K.J., Heaton, J.P., et al. Smoking and other lifestyle factors in relation to erectile dysfunction. BJU Int 96 (2005), 1355–1359.
12. 12 Shiri, R., Hakkinen, J., Koskimaki, J., et al. Smoking causes erectile dysfunction through vascular disease. Urology 68 (2006), 1318–1322.
13. 13 He, J., Reynolds, K., Chen, J., et al. Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease. Am J Epidemiol 166 (2007), 803–809.
14. 14 Kupelian, V., Link, C.L., McKinlay, J.B., Association between smoking, passive smoking, and erectile dysfunction: Results from the Boston Area Community Health (BACH) Survey. Eur Urol 52 (2007), 416–422.
15. 15 Kupelian, V., Araujo, A.B., Chiu, G.R., et al. Relative contributions of modifiable risk factors to erectile dysfunction: Results from the Boston Area Community Health (BACH) Survey. Prev Med 50 (2010), 19–25.
16. 16 Harte, C.B., Meston, C.M., Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: A randomized, double-blind, placebo-controlled trial. J Sex Med 5 (2008), 110–121.
17. 17 Tostes, R.C., Carneiro, F.S., Lee, A.J., et al. Cigarette smoking and erectile dysfunction: Focus on NO bioavailability and ROS generation. J Sex Med 5 (2008), 1284–1295.
18. 18 Bjurlin, M.A., Cohn, M.R., Freeman, V.L., et al. Ethnicity and smoking status are associated with awareness of smoking related genitourinary diseases. J Urol 188 (2012), 724–728.
19. 19 US Department of Health and Human Services. The health consequences of smoking: 50 years of progress. A report of the Surgeon General. 2014, US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta Printed with corrections; January 2014.
20. 20 Glina, S., Reichelt, A.C., Leao, P.P., et al. Impact of cigarette smoking on papaverine-induced erection. J Urol 140 (1988), 523–524.
21. 21 Wabrek, A.J., Shelley, M.M., Horowitz, L.M., et al. Noninvasive penile arterial evaluation in 120 males with erectile dysfunction. Urology 22 (1983), 230–234.
22. 22 Virag, R., Bouilly, P., Frydman, D., Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1 (1985), 181–184.
23. 23 Condra, M., Morales, A., Owen, J.A., et al. Prevalence and significance of tobacco smoking in impotence. Urology 27 (1986), 495–498.
24. 24 Tengs, T.O., Osgood, N.D., The link between smoking and impotence: Two decades of evidence. Prev Med 32 (2001), 447–452.
25. 25 Parazzini, F., Menchini, F.F., Bortolotti, A., et al. Frequency and determinants of erectile dysfunction in Italy. Eur Urol 37 (2000), 43–49.
26. 26 Blanker, M.H., Bohnen, A.M., Groeneveld, F.P., et al. Correlates for erectile and ejaculatory dysfunction in older Dutch men: A community-based study. J Am Geriatr Soc 49 (2001), 436–442.
27. 27 Martin-Morales, A., Sanchez-Cruz, J.J., Saenz de Tejada, I., et al. Prevalence and independent risk factors for erectile dysfunction in Spain: Results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 166 (2001), 569–574.
28. 28 Shiri, R., Hakama, M., Hakkinen, J., et al. Relationship between smoking and erectile dysfunction. Int J Impot Res 17 (2005), 164–169.
29. 29 Lam, T.H., Abdullah, A.S., Ho, L.M., et al. Smoking and sexual dysfunction in Chinese males: Findings from men's health survey. Int J Impot Res 18 (2006), 364–369.
30. 30 Weber, M.F., Smith, D.P., O'Connell, D.L., et al. Risk factors for erectile dysfunction in a cohort of 108 477 Australian men. Med J Aust 199 (2013), 107–111.
31. 31 Bacon, C.G., Mittleman, M.A., Kawachi, I., et al. Sexual function in men older than 50 years of age: Results from the Health Professionals follow-up study. Ann Intern Med 139 (2003), 161–168.
32. 32 Bacon, C.G., Mittleman, M.A., Kawachi, I., et al. A prospective study of risk factors for erectile dysfunction. J Urol 176 (2006), 217–221.
33. 33 Feldman, H.A., Goldstein, I., Hatzichristou, D.G., et al. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 151 (1994), 54–61.
34. 34 Feldman, H.A., Johannes, C.B., Derby, C.A., et al. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts Male Aging Study. Prev Med 30 (2000), 328–338.
35. 35 Cao, S., Yin, X., Wang, Y., et al. Smoking and risk of erectile dysfunction: Systematic review of observational studies with meta-analysis. PLoS One, 8, 2013, e60443.
36. 36 Gilbert, D.G., Hagen, R.L., D'Agostino, J.A., The effects of cigarette smoking on human sexual potency. Addict Behav 11 (1986), 431–434.
37. 37 Millett, C., Wen, L.M., Rissel, C., et al. Smoking and erectile dysfunction: Findings from a representative sample of Australian men. Tob Control 15 (2006), 136–139.
38. 38 Wu, C., Zhang, H., Gao, Y., et al. The association of smoking and erectile dysfunction: Results from the Fangchenggang Area Male Health and Examination Survey (FAMHES). J Androl 33 (2012), 59–65.
39. 39 Cao, S., Gan, Y., Dong, X., et al. Association of quantity and duration of smoking with erectile dysfunction: A dose-response meta-analysis. J Sex Med 11 (2014), 2376–2384.
40. 40 Lue, T.F., Tanagho, E.A., Physiology of erection and pharmacological management of impotence. J Urol 137 (1987), 829–836.
41. 41 Lue, T.F., Erectile dysfunction. N Engl J Med 342 (2000), 1802–1813.
42. 42 Xie, Y., Garban, H., Ng, C., et al. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol 157 (1997), 1121–1126.
43. 43 Xu, H., Qin, W.B., Yu, M., et al. Nicotine reduces endogenous CO concentration and NOS activity in rat corpus cavernosum. Zhonghua Nan Ke Xue 18 (2012), 412–415.
44. 44 Huang, Y.C., Chin, C.C., Chen, C.S., et al. Chronic cigarette smoking impairs erectile function through increased oxidative stress and apoptosis, decreased nNOS, endothelial and smooth muscle contents in a rat model. PLoS One, 10, 2015, e0140728.
45. 45 Celermajer, D.S., Sorensen, K.E., Georgakopoulos, D., et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88 (1993), 2149–2155.
46. 46 Shen, Y., Rattan, V., Sultana, C., Kalra, V.K., Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol Heart Circ Physiol 270 (1996), H1624–H1633.
47. 47 Adams, M.R., Jessup, W., Celermajer, D.S., Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: Reversibility with oral L-arginine but not vitamin C. J Am Coll Cardiol 29 (1997), 491–497.
48. 48 Puranik, R., Celermajer, D.S., Smoking and endothelial function. Prog Cardiovasc Dis 45 (2003), 443–458.
49. 49 Brunner, H., Cockcroft, J.R., Deanfield, J., et al. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 23 (2005), 233–246.
50. 50 Ambrose, J.A., Barua, R.S., The pathophysiology of cigarette smoking and cardiovascular disease: An update. J Am Coll Cardiol 43 (2004), 1731–1737.
51. 51 Guo, X., Oldham, M.J., Kleinman, M.T., et al. Effect of cigarette smoking on nitric oxide, structural, and mechanical properties of mouse arteries. Am J Physiol Heart Circ Physiol 291 (2006), H2354–H2361.
52. 52 Saenz de Tejada, I., Goldstein, I., Azadzoi, K., et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320 (1989), 1025–1030.
53. 53 Kempczinski, R.F., Role of the vascular diagnostic laboratory in the evaluation of male impotence. Am J Surg 138 (1979), 278–282.
54. 54 Hirshkowitz, M., Karacan, I., Howell, J.W., et al. Nocturnal penile tumescence in cigarette smokers with erectile dysfunction. Urology 39 (1992), 101–107.
55. 55 Shabsigh, R., Fishman, I.J., Schum, C., et al. Cigarette smoking and other vascular risk factors in vasculogenic impotence. Urology 38 (1991), 227–231.
56. 56 Bahren, W., Gall, H., Scherb, W., et al. Arterial anatomy and arteriographic diagnosis of arteriogenic impotence. Cardiovasc Interv Radiol 11 (1988), 195–210.
57. 57 Rosen, M.P., Greenfield, A.J., Walker, T.G., et al. Cigarette smoking: An independent risk factor for atherosclerosis in the hypogastric-cavernous arterial bed of men with arteriogenic impotence. J Urol 145 (1991), 759–763.
58. 58 Levine, L.A., Gerber, G.S., Acute vasospasm of penile arteries in response to cigarette smoking. Urology 36 (1990), 99–100.
59. 59 Prezioso, D., Iacono, F., Russo, U., et al. Evaluation of penile cavernosal artery intima-media thickness in patients with erectile dysfunction. A new parameter in the diagnosis of vascular erectile dysfunction. Our experience on 59 cases. Arch Ital Urol Androl 86 (2014), 9–14.
60. 60 Elhanbly, S., Abdel-Gaber, S., Fathy, H., et al. Erectile dysfunction in smokers: A penile dynamic and vascular study. J Androl 25 (2004), 991–995.
61. 61 Goksu, C., Deveer, M., Sivrioglu, A.K., et al. Peripheral atherosclerosis in patients with arterial erectile dysfunction. Int J Impot Res 26 (2014), 55–60.
62. 62 Harte, C.B., Concurrent relations among cigarette smoking status, resting heart rate variability, and erectile response. J Sex Med 11 (2014), 1230–1239.
63. 63 Harte, C.B., Nicotine acutely inhibits erectile tumescence by altering heart rate variability. Urology 83 (2014), 1093–1098.
64. 64 Mersdorf, A., Goldsmith, P.C., Diederichs, W., et al. Ultrastructural changes in impotent penile tissue: A comparison of 65 patients. J Urol 145 (1991), 749–758.
65. 65 Park, M.G., Ko, K.W., Oh, M.M., et al. Effects of smoking on plasma testosterone level and erectile function in rats. J Sex Med 9 (2012), 472–481.
66. 66 Mok, J.S., Paisley, K., Martin, W., Inhibition of nitrergic neurotransmission in the bovine retractor penis muscle by an oxidant stress: Effects of superoxide dismutase mimetics. Br J Pharmacol 124 (1998), 111–118.
67. 67 DeYoung, L., Yu, D., Bateman, R.M., et al. Oxidative stress and antioxidant therapy: Their impact in diabetes-associated erectile dysfunction. J Androl 25 (2004), 830–836.
68. 68 Koupparis, A.J., Jeremy, J.Y., Muzaffar, S., et al. Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU Int 96 (2005), 423–427.
69. 69 Shukla, N., Jones, R., Persad, R., et al. Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. Eur J Pharmacol 517 (2005), 224–231.
70. 70 Kovanecz, I., Ferrini, M.G., Vernet, D., et al. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int 98 (2006), 116–124.
71. 71 Ozkara, H., Alan, C., Atukeren, P., et al. Changes of nitric oxide synthase-containing nerve fibers and parameters for oxidative stress after unilateral cavernous nerve resection or manipulation in rat penis. Chin J Physiol 49 (2006), 160–166.
72. 72 Hotston, M.R., Jeremy, J.Y., Bloor, J., et al. Sildenafil inhibits the up-regulation of phosphodiesterase type 5 elicited with nicotine and tumour necrosis factor-alpha in cavernosal vascular smooth muscle cells: Mediation by superoxide. BJU Int 99 (2007), 612–618.
73. 73 Goldstein, I., Feldman, M.I., Deckers, P.J., et al. Radiation-associated impotence: A clinical study of its mechanism. JAMA 251 (1984), 903–910.
74. 74 Gades, N.M., Nehra, A., Jacobson, D.J., et al. Association between smoking and erectile dysfunction: A population-based study. Am J Epidemiol 161 (2005), 346–351.
75. 75 Capogrosso, P., Colicchia, M., Ventimiglia, E., et al. One patient out of four with newly diagnosed erectile dysfunction is a young man—worrisome picture from the everyday clinical practice. J Sex Med 10 (2013), 1833–1841.
76. 76 Elist, J., Jarman, W.D., Edson, M., Evaluating medical treatment of impotence. Urology 23 (1984), 374–375.
77. 77 Forsberg, L., Hederstrom, E., Olsson, A.M., Severe arterial insufficiency in impotence confirmed with an improved angiographic technique: The impact of smoking and some other etiologic factors. Eur Urol 16 (1989), 357–360.
78. 78 Guay, A.T., Perez, J.B., Heatley, G.J., Cessation of smoking rapidly decreases erectile dysfunction. Endocr Pract 4 (1998), 23–26.
79. 79 Sighinolfi, M.C., Mofferdin, A., De, S.S., et al. Immediate improvement in penile hemodynamics after cessation of smoking: Previous results. Urology 69 (2007), 163–165.
80. 80 Derby, C.A., Mohr, B.A., Goldstein, I., et al. Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk?. Urology 56 (2000), 302–306.
81. 81 Travison, T.G., Shabsigh, R., Araujo, A.B., et al. The natural progression and remission of erectile dysfunction: Results from the Massachusetts Male Aging Study. J Urol 177 (2007), 241–246.
82. 82 Harte, C.B., Meston, C.M., Association between smoking cessation and sexual health in men. BJU Int 109 (2012), 888–896.
83. 83 Celermajer, D.S., Adams, M.R., Clarkson, P., et al. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 334 (1996), 150–155.